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IRX2 iroquois homeobox 2 [ Homo sapiens (human) ]

Gene ID: 153572, updated on 26-May-2016
Official Symbol
IRX2provided by HGNC
Official Full Name
iroquois homeobox 2provided by HGNC
Primary source
HGNC:HGNC:14359
See related
Ensembl:ENSG00000170561 HPRD:09368; MIM:606198; Vega:OTTHUMG00000090377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRXA2
Summary
IRX2 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[supplied by OMIM, Apr 2004]
Orthologs
Location:
5p15.33
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (2741863..2751655, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (2746279..2751769, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374618 Neighboring gene uncharacterized LOC100506858 Neighboring gene 3-hydroxyisobutyryl-Coenzyme A hydrolase pseudogene Neighboring gene chromosome 5 open reading frame 38

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proximal/distal pattern formation involved in metanephric nephron development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
specification of loop of Henle identity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
iroquois-class homeodomain protein IRX-2
Names
homeodomain protein IRXA2
iroquois homeobox protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134222.1NP_001127694.1  iroquois-class homeodomain protein IRX-2

    See identical proteins and their annotated locations for NP_001127694.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1.
    Source sequence(s)
    AY335940, BC065189, BM969863
    Consensus CDS
    CCDS3868.1
    UniProtKB/Swiss-Prot
    Q9BZI1
    Related
    ENSP00000372056, OTTHUMP00000115435, ENST00000382611, OTTHUMT00000206749
    Conserved Domains (2) summary
    smart00548
    Location:322339
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    cd00086
    Location:118176
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_033267.4NP_150366.1  iroquois-class homeodomain protein IRX-2

    See identical proteins and their annotated locations for NP_150366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AB188492, AI131378, AI928035, AY335940, BC065189, BM969863
    Consensus CDS
    CCDS3868.1
    UniProtKB/Swiss-Prot
    Q9BZI1
    Related
    ENSP00000307006, OTTHUMP00000220684, ENST00000302057, OTTHUMT00000365962
    Conserved Domains (2) summary
    smart00548
    Location:322339
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    cd00086
    Location:118176
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    2741863..2751655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513979.1XP_011512281.1  

    See identical proteins and their annotated locations for XP_011512281.1

    UniProtKB/Swiss-Prot
    Q9BZI1
    Conserved Domains (2) summary
    smart00548
    Location:322339
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    cd00086
    Location:118176
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_011513978.1XP_011512280.1  

    See identical proteins and their annotated locations for XP_011512280.1

    UniProtKB/Swiss-Prot
    Q9BZI1
    Conserved Domains (2) summary
    smart00548
    Location:322339
    IRO; Motif in Iroquois-class homeodomain proteins (only). Unknown function
    cd00086
    Location:118176
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    2746153..2751637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)