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Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase [ Mus musculus (house mouse) ]

Gene ID: 15357, updated on 8-May-2016
Official Symbol
Hmgcrprovided by MGI
Official Full Name
3-hydroxy-3-methylglutaryl-Coenzyme A reductaseprovided by MGI
Primary source
MGI:MGI:96159
See related
Ensembl:ENSMUSG00000021670 Vega:OTTMUSG00000035511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Red; HMG-CoAR
Orthologs
Location:
13 D1; 13 50.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (96648962..96670936, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (97418917..97440891, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), kappa Neighboring gene collagen, type IV, alpha 3 (Goodpasture antigen) binding protein Neighboring gene predicted gene, 33171 Neighboring gene ankyrin repeat domain 31

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC103269

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NADP binding IEA
Inferred from Electronic Annotation
more info
 
NADPH binding ISO
Inferred from Sequence Orthology
more info
 
coenzyme binding ISO
Inferred from Sequence Orthology
more info
 
hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
hydroxymethylglutaryl-CoA reductase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
coenzyme A metabolic process IEA
Inferred from Electronic Annotation
more info
 
embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
isoprenoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
isoprenoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of striated muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
ubiquinone metabolic process ISO
Inferred from Sequence Orthology
more info
 
visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
peroxisomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Names
3-hydroxy-3-methylglutaryl-CoA reductase
HMG-CoA reductase
NP_032281.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008255.2NP_032281.2  3-hydroxy-3-methylglutaryl-coenzyme A reductase

    See identical proteins and their annotated locations for NP_032281.2

    Status: VALIDATED

    Source sequence(s)
    AC154851, AK048784, AK079302, AK159899, BM899288, BY124492
    Consensus CDS
    CCDS26706.1
    UniProtKB/Swiss-Prot
    Q01237
    UniProtKB/TrEMBL
    Q8BV96
    Related
    ENSMUSP00000022176, OTTMUSP00000050014, ENSMUST00000022176, OTTMUST00000090933
    Conserved Domains (3) summary
    cd00643
    Location:464870
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:88218
    MMPL; MMPL family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    96648962..96670936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517531.1XP_006517594.1  

    See identical proteins and their annotated locations for XP_006517594.1

    UniProtKB/Swiss-Prot
    Q01237
    Conserved Domains (3) summary
    cd00643
    Location:464870
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:1887
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:88218
    MMPL; MMPL family
  2. XM_006517530.1XP_006517593.1  

    Conserved Domains (3) summary
    cd00643
    Location:474880
    HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
    TIGR00920
    Location:11897
    2A060605; 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    cl21543
    Location:98228
    MMPL; MMPL family

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    100288206..100310264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)