Hmgb1 high mobility group box 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Hmgb1provided by MGI
Official Full Name: high mobility group box 1provided by MGI
Primary source: MGI:96113
Locus tag: mCG_144566
See related: Ensembl:ENSMUSG00000066551; Vega:OTTMUSG00000016672
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DEF; p30; Hmg1; HMG-1; SBP-1; amphoterin

Genomic context

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Location :: 5 G3; 5 89.18 cM

Sequence :: Chromosome: 5; NC_000071.6 (149047227..149053037, complement)

See Hmgb1 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Liver tissue damage and cell necrosis lead to early HMGB1 release, and HMGB1 acts synergistically with TNF-alpha to promote pathological processes in acute liver failure.
Title: Synergistic effects of antibodies against high-mobility group box 1 and tumor necrosis factor-α antibodies on D-(+)-galactosamine hydrochloride/lipopolysaccharide-induced acute liver failure.
interactions between HMGB1 and TLR4 enhance the formation of neutrophil extracellular traps and provide a novel mechanism through which HMGB1 may contribute to the severity of neutrophil-associated inflammatory conditions
Title: HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4.
curcumin pretreatment protects the mice from concanavilin A-induced liver injury via inhibiting hepatocyte oxidative stress, inflammation and releasing of HMGB1.
Title: Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice.
TWEAK can regulate expression and secretion of HMGB1 in monocytes/macrophages, participating in the inflammatory response associated with atherosclerotic plaque development.
Title: HMGB1 expression and secretion are increased via TWEAK-Fn14 interaction in atherosclerotic plaques and cultured monocytes.
IL-2 induced HMGB1 cytoplasmic translocation in MEFs and promoted interaction between HMGB1 and beclin1, which is required for autophagy induction.
Title: Autophagy is required for IL-2-mediated fibroblast growth.
The chaperone-like activity of HMGB1 inhibits formation of aggregates and toxicity caused by expanded polyglutamine (polyQ); overexpression of HMGB1 or exogenous administration of recombinant HMGB1 remarkably reduces polyQ aggregates in SHSY5Y cells.
Title: Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.
High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.
Title: High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.
The HMGB1-TLR4-IL-23 pathway in macrophages makes the generation of IL-17-producing gammadelta T cells, which mediates neutrophil infiltration and damage-induced liver inflammation.
Title: High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of γδ T cells with macrophages.
HMGB1-receptor for advanced glycation end-products (RAGE) signaling is required for myogenin induction and myogenin-dependent repression of paired-box(Pax)7 transcription.
Title: HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK- and myogenin-dependent repression of Pax7 transcription.
the use of GR significantly improved anticancer effectiveness of the CAMEL peptide via HMGB1 inhibition
Title: The role of Glycyrrhizin, an inhibitor of HMGB1 protein, in anticancer therapy.

Submit: New GeneRIF Correction See all (169)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_034569.1	NP_034477.1	Aes		BIND	PubMed	Hmgb1 interacts with Aes (Grg5). This interaction was modelled on a demonstrated interaction between rat HMGB1 and mouse Aes (Grg5).
NP_034569.1	NP_035729.2	Tle1		BIND	PubMed	Hmgb1 interacts with Tle1 (Grg1). This interaction was modelled on a demonstrated interaction between rat Hmgb1 and mouse Tle1 (Grg1).

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of DNA fragmentation factor, organism-specific biosystem (from REACTOME)
Activation of DNA fragmentation factor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Advanced glycosylation endproduct receptor signaling, organism-specific biosystem (from REACTOME)
Advanced glycosylation endproduct receptor signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis induced DNA fragmentation, organism-specific biosystem (from REACTOME)
Apoptosis induced DNA fragmentation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Base excision repair, organism-specific biosystem (from KEGG)
Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Base excision repair, conserved biosystem (from KEGG)
Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAI mediated induction of type I IFNs, organism-specific biosystem (from REACTOME)
DAI mediated induction of type I IFNs, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88 cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
MyD88 dependent cascade initiated on endosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
RIP-mediated NFkB activation via DAI, organism-specific biosystem (from REACTOME)
RIP-mediated NFkB activation via DAI, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystem (from REACTOME)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated NF-kB activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated NF-kB activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

D5Mit287 (e-PCR), detects polymorphism
- UniSTS:130425

GDB:554977 (e-PCR)
- UniSTS:157665

Hmgb1 (e-PCR), detects polymorphism
- UniSTS:143350

Homology

Homologs of the Hmgb1 gene: The Hmgb1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Clone Names

MGC103168, MGC103169, MGC117896, MGC117897

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
5S rRNA binding	ISO Inferred from Sequence Orthology more info
DNA binding, bending	ISO Inferred from Sequence Orthology more info
RAGE receptor binding	ISO Inferred from Sequence Orthology more info
bent DNA binding	ISO Inferred from Sequence Orthology more info
calcium-dependent protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
crossed form four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
cytokine activity	IDA Inferred from Direct Assay more info	PubMed
cytokine activity	ISO Inferred from Sequence Orthology more info
double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
glycolipid binding	ISO Inferred from Sequence Orthology more info
heparin binding	ISO Inferred from Sequence Orthology more info
open form four-way junction DNA binding	ISO Inferred from Sequence Orthology more info
peptide binding	ISO Inferred from Sequence Orthology more info
protein dimerization activity	ISO Inferred from Sequence Orthology more info
protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
repressing transcription factor binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
DNA geometric change	ISO Inferred from Sequence Orthology more info
V(D)J recombination	ISO Inferred from Sequence Orthology more info
actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
base-excision repair, DNA ligation	ISO Inferred from Sequence Orthology more info
cell morphogenesis	ISO Inferred from Sequence Orthology more info
chemotaxis	ISO Inferred from Sequence Orthology more info
eye development	IMP Inferred from Mutant Phenotype more info	PubMed
induction of positive chemotaxis	ISO Inferred from Sequence Orthology more info
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
male-specific defense response to bacterium	ISO Inferred from Sequence Orthology more info
myoblast proliferation	ISO Inferred from Sequence Orthology more info
negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	ISO Inferred from Sequence Orthology more info
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
nervous system development	ISO Inferred from Sequence Orthology more info
neuron projection development	ISO Inferred from Sequence Orthology more info
positive regulation of DNA binding	ISO Inferred from Sequence Orthology more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of cell death	ISO Inferred from Sequence Orthology more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of glycogen catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of myeloid cell differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
response to glucocorticoid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
response to interferon-gamma	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
condensed chromosome	ISO Inferred from Sequence Orthology more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
neuron projection	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: high mobility group protein B1

Names: high mobility group protein B1; high mobility group protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010439.3 → NP_034569.1 high mobility group protein B1

Status: VALIDATED

Source sequence(s)

AK084841, BP760493

Consensus CDS

CCDS19883.1

UniProtKB/Swiss-Prot

P63158

UniProtKB/TrEMBL

Q58EV5

Related

ENSMUSP00000082682, OTTMUSP00000018031, ENSMUST00000085546, OTTMUST00000040356

Conserved Domains (2) summary

cd00084
Location:95 – 143
Blast Score: 132

HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...

cd01390
Location:9 – 76
Blast Score: 152

HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

149047227..149053037, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

147061615..147067633, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01050894.1 (2118..6827)	None
genomic	AAHY01050895.1	None
genomic	AC158782.5 (206147..211954)	None
genomic	CH466614.1	EDL05858.1	mixed
genomic	HB872519.1	CBF60315.1
genomic	HB872531.1	CBF60321.1
genomic	HB874157.1	CBF61325.1
genomic	HB874169.1	CBF61331.1
genomic	HB874990.1	CBF61868.1
genomic	HB875002.1	CBF61874.1
genomic	HB903072.1	CBF82131.1
genomic	HB903084.1	CBF82146.1
genomic	HC929928.1	CBU85559.1
genomic	HC929940.1	CBU85565.1
genomic	HC931566.1	CBU86353.1
genomic	HC931578.1	CBU86359.1
genomic	HC932399.1	CBU86744.1
genomic	HC932411.1	CBU86750.1
genomic	HC960481.1	CBV00243.1
genomic	HC960493.1	CBV00249.1
genomic	X80457.1	CAA56631.1	129/Sv
genomic	X80458.1	None	129/Sv
mRNA	AK034535.1	None	C57BL/6J
mRNA	AK037928.1	BAC29902.1	C57BL/6J
mRNA	AK050659.1	BAC34367.1	C57BL/6J
mRNA	AK051800.1	BAC34773.1	C57BL/6J
mRNA	AK082902.1	BAC38678.1	C57BL/6J
mRNA	AK084841.1	BAC39289.1	C57BL/6J
mRNA	AK087949.1	None	NOD
mRNA	AK088347.1	None	NOD
mRNA	AK134228.1	None	C57BL/6J
mRNA	AK144428.1	None	C57BL/6J
mRNA	AK146420.1	BAE27155.1	DBA/2
mRNA	AK150924.1	BAE29962.1	C57BL/6J
mRNA	AK157846.1	BAE34226.1	C57BL/6J
mRNA	AK166007.1	None
mRNA	AK206984.1	None
mRNA	BC006586.1	AAH06586.1	CZECHII
mRNA	BC008565.1	AAH08565.1	CZECHII
mRNA	BC064790.1	AAH64790.1	C57BL/6J
mRNA	BC083067.1	AAH83067.1	FVB/N-3
mRNA	BC085090.1	AAH85090.1	FVB/N-3
mRNA	BC091741.1	AAH91741.1	FVB/N
mRNA	BC094030.1	AAH94030.1	FVB/N
mRNA	BC100312.1	AAI00313.1
mRNA	BC110667.1	AAI10668.1	CZECHII
mRNA	BC111468.1	AAI11469.1	FVB/N
mRNA	BP760493.1	None	C57BL/6
mRNA	L38477.1	AAA57042.1	AKR/J
mRNA	U00431.1	AAA20508.1
mRNA	Z11997.1	CAA78042.1	C3H/He