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Hipk3 homeodomain interacting protein kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 15259, updated on 8-May-2016
Official Symbol
Hipk3provided by MGI
Official Full Name
homeodomain interacting protein kinase 3provided by MGI
Primary source
MGI:MGI:1314882
See related
Ensembl:ENSMUSG00000027177 Vega:OTTMUSG00000014944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PKY; DYRK6; FIST3; mir-1902
Orthologs
Location:
2; 2 E2
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (104426481..104494489, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (104266638..104334646, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430041D05 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 35606 Neighboring gene microRNA 1902 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene SWIM type zinc finger 7 associated protein 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
mRNA transcription ISO
Inferred from Sequence Orthology
more info
 
negative regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Preferred Names
homeodomain-interacting protein kinase 3
Names
ANPK
FIST
HCMV-interacting protein
androgen receptor-interacting nuclear protein kinase
fas-interacting serine/threonine-protein kinase
nbak3
nuclear body-associated kinase 3
NP_001139296.1
NP_034564.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145824.1NP_001139296.1  homeodomain-interacting protein kinase 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
    Source sequence(s)
    AK140130, AL844591, BC131664
    UniProtKB/TrEMBL
    A2RRJ7, Q3UST3
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:196525
    PKc_like; Protein Kinases, catalytic domain
  2. NM_010434.2NP_034564.2  homeodomain-interacting protein kinase 3 isoform 1

    See identical proteins and their annotated locations for NP_034564.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK140130, AL844591, AL954370
    Consensus CDS
    CCDS16489.1
    UniProtKB/Swiss-Prot
    Q9ERH7
    UniProtKB/TrEMBL
    Q3UST3
    Related
    ENSMUSP00000028600, OTTMUSP00000015886, ENSMUST00000028600, OTTMUST00000035479
    Conserved Domains (2) summary
    smart00220
    Location:197525
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:196525
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    104426481..104494489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    105663732..105714737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)