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Hic1 hypermethylated in cancer 1 [ Mus musculus (house mouse) ]

Gene ID: 15248, updated on 8-May-2016
Official Symbol
Hic1provided by MGI
Official Full Name
hypermethylated in cancer 1provided by MGI
Primary source
MGI:MGI:1338010
See related
Ensembl:ENSMUSG00000043099 Vega:OTTMUSG00000006196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HIC-1; AA408311
Orthologs
Location:
11 B5; 11 45.76 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (75164565..75170255, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (74978067..74983757, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene Neighboring gene predicted gene, 35054 Neighboring gene microRNA 212 Neighboring gene microRNA 132

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hypermethylated in cancer 1 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098203.1NP_001091673.1  hypermethylated in cancer 1 protein isoform 2

    See identical proteins and their annotated locations for NP_001091673.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL603905, BU757195, CJ126522
    UniProtKB/Swiss-Prot
    Q9R1Y5
    Conserved Domains (5) summary
    COG5048
    Location:561609
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:535557
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:37152
    BTB; BTB/POZ domain
    pfam13465
    Location:578602
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:537557
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_010430.2NP_034560.2  hypermethylated in cancer 1 protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL603905, BU757195, CJ067923
    Consensus CDS
    CCDS36226.1
    UniProtKB/TrEMBL
    Z4YJP0
    Related
    ENSMUSP00000053483, OTTMUSP00000006488, ENSMUST00000055619, OTTMUST00000013968
    Conserved Domains (5) summary
    COG5048
    Location:721769
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:695717
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:197312
    BTB; BTB/POZ domain
    pfam13465
    Location:738762
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:697717
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    75164565..75170255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532275.1XP_006532338.1  

    Conserved Domains (5) summary
    COG5048
    Location:542590
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:516538
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:18133
    BTB; BTB/POZ domain
    pfam13465
    Location:559583
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:518538
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    82671336..82677017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)