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Hhip Hedgehog-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 15245, updated on 10-May-2016
Official Symbol
Hhipprovided by MGI
Official Full Name
Hedgehog-interacting proteinprovided by MGI
Primary source
MGI:MGI:1341847
See related
Ensembl:ENSMUSG00000064325
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hhip1
Orthologs
Location:
8 37.95 cM; 8 C3
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 8 NC_000074.6 (79965850..80058070, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (82489750..82581907, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene anaphase promoting complex subunit 10 Neighboring gene predicted gene, 30494 Neighboring gene predicted gene, 39206 Neighboring gene predicted gene, 39207 Neighboring gene predicted gene, 33096

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Basal cell carcinoma, organism-specific biosystem (from KEGG)
    Basal cell carcinoma, organism-specific biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Basal cell carcinoma, conserved biosystem (from KEGG)
    Basal cell carcinoma, conserved biosystemCancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare fam...
  • Hedgehog 'on' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'on' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
  • Hedgehog signaling pathway, organism-specific biosystem (from KEGG)
    Hedgehog signaling pathway, organism-specific biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Hedgehog signaling pathway, conserved biosystem (from KEGG)
    Hedgehog signaling pathway, conserved biosystemThe Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and or...
  • Ligand-receptor interactions, organism-specific biosystem (from REACTOME)
    Ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
hedgehog family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
hedgehog family protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
quinone binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
hedgehog-interacting protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020259.4NP_064655.4  hedgehog-interacting protein precursor

    See identical proteins and their annotated locations for NP_064655.4

    Status: VALIDATED

    Source sequence(s)
    AC109146, AK031841, AW121326, BC053012, BY142826, CV561558
    Consensus CDS
    CCDS22440.1
    UniProtKB/Swiss-Prot
    Q7TN16
    Related
    ENSMUSP00000078047, OTTMUSP00000040485, ENSMUST00000079038, OTTMUST00000076798
    Conserved Domains (2) summary
    pfam03024
    Location:38220
    Folate_rec; Folate receptor family
    pfam07995
    Location:237432
    GSDH; Glucose / Sorbosone dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p3 C57BL/6J

    Range
    79965850..80058070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530702.2XP_006530765.1  

    Conserved Domains (2) summary
    pfam03024
    Location:38220
    Folate_rec; Folate receptor family
    pfam07995
    Location:237432
    GSDH; Glucose / Sorbosone dehydrogenase

Alternate Mm_Celera

Genomic

  1. AC_000030.1 Alternate Mm_Celera

    Range
    84241203..84333109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)