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NEK10 NIMA related kinase 10 [ Homo sapiens (human) ]

Gene ID: 152110, updated on 12-May-2016
Official Symbol
NEK10provided by HGNC
Official Full Name
NIMA related kinase 10provided by HGNC
Primary source
HGNC:HGNC:18592
See related
Ensembl:ENSG00000163491 HPRD:08135; Vega:OTTHUMG00000130571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs
Location:
3p24.1
Exon count:
49
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (27107336..27369460, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (27257097..27410912, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377003 Neighboring gene leucine rich repeat containing 3B Neighboring gene uncharacterized LOC105377004 Neighboring gene mitochondrial inner membrane organizing system 1 pseudogene 3 Neighboring gene solute carrier family 4 member 7 Neighboring gene ribosomal protein S20 pseudogene 15 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ32685

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule-based process IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle G2/M phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
protein kinase complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase Nek10
Names
NIMA (never in mitosis gene a)- related kinase 10
NIMA-related kinase 10
never in mitosis A-related kinase 10
nimA-related protein kinase 10
NP_001026911.1
NP_001291313.1
NP_689747.3
NP_955379.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031741.3NP_001026911.1  serine/threonine-protein kinase Nek10 isoform 1

    See identical proteins and their annotated locations for NP_001026911.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and contains multiple differences in the coding region compared to variant 2, including lacking multiple 5' coding exons. It initiates translation at an alternate start codon. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK098832, BC045758, DB045668
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000373281, OTTHUMP00000208384, ENST00000383771, OTTHUMT00000340979
    Conserved Domains (1) summary
    cl21453
    Location:1097
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001304384.1NP_001291313.1  serine/threonine-protein kinase Nek10 isoform 4

    See identical proteins and their annotated locations for NP_001291313.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks multiple 5' coding exons, compared to variant 2. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093555, AC098931, AK057247, BC045758, DB045668
    Consensus CDS
    CCDS77713.1
    UniProtKB/Swiss-Prot
    Q6ZWH5
    Related
    ENSP00000295720, OTTHUMP00000208391, ENST00000295720, OTTHUMT00000340992
    Conserved Domains (1) summary
    cl21453
    Location:1097
    PKc_like; Protein Kinases, catalytic domain
  3. NM_152534.4NP_689747.3  serine/threonine-protein kinase Nek10 isoform 2

    See identical proteins and their annotated locations for NP_689747.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the inferred longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AC093555, AC098931, AK057247, AK098832, AK123061, BC045758, DB094082
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000395849, OTTHUMP00000257281, ENST00000429845, OTTHUMT00000438156
    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  4. NM_199347.3NP_955379.2  serine/threonine-protein kinase Nek10 isoform 3

    See identical proteins and their annotated locations for NP_955379.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, compared to variant 2, resulting in a different 3' coding region and 3' UTR. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 2.
    Source sequence(s)
    AK098832, AK123061, BX537852, DB094082
    Consensus CDS
    CCDS46781.1
    UniProtKB/Swiss-Prot
    Q6ZWH5
    UniProtKB/TrEMBL
    Q8N774
    Related
    ENSP00000343847, OTTHUMP00000208385, ENST00000341435, OTTHUMT00000340980
    Conserved Domains (2) summary
    smart00220
    Location:519695
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518697
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    27107336..27369460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712999.2XP_006713062.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  2. XM_006713001.2XP_006713064.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  3. XM_006712997.2XP_006713060.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  4. XM_006712998.2XP_006713061.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  5. XM_011533407.1XP_011531709.1  

    See identical proteins and their annotated locations for XP_011531709.1

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  6. XM_011533410.1XP_011531712.1  

    Conserved Domains (2) summary
    smart00220
    Location:519733
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518739
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011533412.1XP_011531714.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  8. XM_011533411.1XP_011531713.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  9. XM_011533409.1XP_011531711.1  

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  10. XM_011533404.1XP_011531706.1  

    See identical proteins and their annotated locations for XP_011531706.1

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  11. XM_011533405.1XP_011531707.1  

    See identical proteins and their annotated locations for XP_011531707.1

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  12. XM_011533406.1XP_011531708.1  

    See identical proteins and their annotated locations for XP_011531708.1

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  13. XM_011533408.1XP_011531710.1  

    See identical proteins and their annotated locations for XP_011531710.1

    Conserved Domains (2) summary
    smart00220
    Location:519779
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08528
    Location:518785
    STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10
  14. XM_011533414.1XP_011531716.1  

    Conserved Domains (2) summary
    smart00220
    Location:519669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518672
    PKc_like; Protein Kinases, catalytic domain
  15. XM_006713002.1XP_006713065.1  

    See identical proteins and their annotated locations for XP_006713065.1

    Conserved Domains (2) summary
    smart00220
    Location:519695
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518697
    PKc_like; Protein Kinases, catalytic domain
  16. XM_011533415.1XP_011531717.1  

    Conserved Domains (2) summary
    smart00220
    Location:519649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518651
    PKc_like; Protein Kinases, catalytic domain
  17. XM_011533413.1XP_011531715.1  

    Conserved Domains (2) summary
    smart00220
    Location:519669
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:518672
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_940384.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    27102338..27360939 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)