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Hells helicase, lymphoid specific [ Mus musculus (house mouse) ]

Gene ID: 15201, updated on 30-May-2016
Official Symbol
Hellsprovided by MGI
Official Full Name
helicase, lymphoid specificprovided by MGI
Primary source
MGI:MGI:106209
See related
Ensembl:ENSMUSG00000025001 Vega:OTTMUSG00000021232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LSH; Lysh; PASG; YFK8; AI323785; E130115I21Rik
Orthologs
Location:
19; 19 C3-D1
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (38930990..38970470)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (39005480..39042767)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1D12: TBC1 domain family, member 12 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 55

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
maintenance of DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation-dependent chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
pericentric heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
urogenital system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
lymphocyte-specific helicase
Names
hells
proliferation-associated SNF2-like protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008234.3NP_032260.2  lymphocyte-specific helicase

    See identical proteins and their annotated locations for NP_032260.2

    Status: VALIDATED

    Source sequence(s)
    AF155210
    Consensus CDS
    CCDS29789.1
    UniProtKB/Swiss-Prot
    Q60848
    Related
    ENSMUSP00000025965, OTTMUSP00000023455, ENSMUST00000025965, OTTMUST00000050285
    Conserved Domains (4) summary
    COG0513
    Location:546802
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00046
    Location:226368
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:577703
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:209560
    SNF2_N; SNF2 family N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    38930990..38970470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526699.2XP_006526762.1  

    See identical proteins and their annotated locations for XP_006526762.1

    UniProtKB/Swiss-Prot
    Q60848
    Conserved Domains (4) summary
    COG0513
    Location:546802
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00046
    Location:226368
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd00079
    Location:577703
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00176
    Location:209560
    SNF2_N; SNF2 family N-terminal domain
  2. XM_006526700.2XP_006526763.1  

    Conserved Domains (1) summary
    cd00079
    Location:233359
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    39732380..39769659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)