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    SGOL1 shugoshin-like 1 (S. pombe) [ Homo sapiens ]

    Gene ID: 151648, updated on 11-May-2012
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    Summary

    Official Symbol
    SGOL1provided by HGNC
    Official Full Name
    shugoshin-like 1 (S. pombe)provided by HGNC
    Primary source
    HGNC:25088
    See related
    Ensembl:ENSG00000129810; HPRD:12377; MIM:609168; Vega:OTTHUMG00000130479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGO; Sgo1; NY-BR-85; FLJ14230
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    Genomic context

    Location :
    3p24.3
    Sequence :
    Chromosome: 3; NC_000003.11 (20202085..20227724, complement)
    See SGOL1 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 18 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene microRNA 3135a Neighboring gene VENT homeobox pseudogene 7 Neighboring gene zinc finger protein 385D

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth. Liu L, et al. Tumour Biol, 2012 Apr. PMID 22161216.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion. Kahyo T, et al. Oncogene, 2011 Nov 3. PMID 21532624.
    4. Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells. Kang J, et al. Mol Biol Cell, 2011 Apr 15. PMID 21346195.
    5. Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation. Tsukahara T, et al. Nature, 2010 Oct 7. PMID 20739936.

    See all (37) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth
      Title: Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth.
    2. These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability.
      Title: A novel tumor-derived SGOL1 variant causes abnormal mitosis and unstable chromatid cohesion.
    3. HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres.
      Title: Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells.
    4. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export.
      Title: Germinal center-associated nuclear protein (GANP) is involved in mRNA export of Shugoshin-1 required for centromere cohesion and in sister-chromatid exchange.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Report structure and function of the PP2A-shugoshin interaction.
      Title: Structure and function of the PP2A-shugoshin interaction.
    7. the spindle checkpoint kinase Bub1 contributes to the maintenance of Sgo1 steady-state protein levels in an APC/C-independent mechanism.
      Title: Multiple anaphase-promoting complex/cyclosome degrons mediate the degradation of human Sgo1.
    8. findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of chromosome instability (CIN), and hSgo1 downregulation leads to CIN in colorectal cancer cells.
      Title: Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer.
    9. the direct link between HP1 and shugoshin is conserved in human cells
      Title: Heterochromatin links to centromeric protection by recruiting shugoshin.
    10. Centriole splitting induced by Sgo1 depletion or expression of a dominant negative mutant is suppressed by ectopic expression of sSgo1 or by Plk1 knockdown.
      Title: sSgo1, a major splice variant of Sgo1, functions in centriole cohesion where it is regulated by Plk1.
    Submit: New GeneRIF Correction See all (19)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q5FBB7 Q96AG4 LRRC59    HPRD  PubMed  
    Q5FBB7 Protein phosphatase 2A, catalytic subunit, alpha isoform PPP2CA    HPRD  PubMed  
    Q5FBB7 P62714 PPP2CB    HPRD  PubMed  
    Q5FBB7 P30153 PPP2R1A    HPRD  PubMed  
    Q5FBB7 P30154 PPP2R1B    HPRD  PubMed  
    Q5FBB7 Q15172 PPP2R5A    HPRD  PubMed  
    Q5FBB7 Q15173 PPP2R5B    HPRD  PubMed  
    Q5FBB7 Q13362 PPP2R5C    HPRD  PubMed  
    Q5FBB7 Q14738 PPP2R5D    HPRD  PubMed  
    Q5FBB7 Q16537 PPP2R5E    HPRD  PubMed  
    Q5FBB7 P78527 PRKDC    HPRD  PubMed  
    Q5FBB7 P62906 RPL10A    HPRD  PubMed  
    Q5FBB7 P46779 RPL28    HPRD  PubMed  
    Q5FBB7 P18124 RPL7    HPRD  PubMed  
    Q5FBB7 P62424 RPL7A    HPRD  PubMed  
    Q5FBB7 P05386 RPLP1    HPRD  PubMed  
    Q5FBB7 Q01105 SET    HPRD  PubMed  
    Q5FBB7 Q5FBB7 SGOL1    HPRD  PubMed  
    Q5FBB7 P13010 XRCC5    HPRD  PubMed  
    Q5FBB7 P12956 XRCC6    HPRD  PubMed  
    BioGRID:127395 BioGRID:114646 AURKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127395 BioGRID:117030 CBX5    BioGRID  PubMed Co-localization 
    BioGRID:127395 BioGRID:120446 CDCA8    BioGRID  PubMed Two-hybrid 
    BioGRID:127395 BioGRID:109831 INCENP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127395 BioGRID:117433 NSL1    BioGRID  PubMed Co-localization 
    BioGRID:127395 BioGRID:111362 PLK1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:127395 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127395 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127395 BioGRID:111510 PPP2R1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127395 BioGRID:206176 Ppp2r1a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127395 BioGRID:215364 Sgol1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:127395 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora B signaling, organism-specific biosystem
      Aurora B signaling
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    centriole-centriole cohesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome segregation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    meiotic chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    condensed chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    condensed nuclear chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    shugoshin-like 1
    Names
    shugoshin-like 1
    hSgo1
    shugoshin 1AB protein
    shugoshin 1CD protein
    shugoshin 1EF protein
    shugoshin 1GH protein
    shugoshin 1KL protein
    serologically defined breast cancer antigen NY-BR-85
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012409.2 → NP_001012409.1  shugoshin-like 1 isoform A1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A1) lacks the 3' exon and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (A1, also known as L1) has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB187577, AC099057, AF308299, BG530826
      Consensus CDS
      CCDS46773.1
      UniProtKB/TrEMBL
      B5BUA4
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000406880, ENST00000412868
      Conserved Domains (2) summary
      pfam07557
      Location:471 – 496
      Blast Score: 110
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 125
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    2. NM_001012410.3 → NP_001012410.1  shugoshin-like 1 isoform A2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A2) and variant A4 encode the same longest isoform (A2, also known as 1EF).
      Source sequence(s)
      AB187578, AB190994, BG530826
      Consensus CDS
      CCDS33716.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000263753, OTTHUMP00000208169, ENST00000263753, OTTHUMT00000340498
      Conserved Domains (2) summary
      pfam07557
      Location:471 – 496
      Blast Score: 109
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 128
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    3. NM_001012411.2 → NP_001012411.1  shugoshin-like 1 isoform B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B1) lacks an in-frame internal segment and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (B1, also known as 1CD) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB193058, AC099057, AF308299, BG530826
      Consensus CDS
      CCDS46774.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000389034, OTTHUMP00000208163, ENST00000437051, OTTHUMT00000340492
      Conserved Domains (2) summary
      pfam07557
      Location:219 – 244
      Blast Score: 108
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 120
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    4. NM_001012412.3 → NP_001012412.1  shugoshin-like 1 isoform B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B2) lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (B2, also known as 1GH) lacks an internal segment, as compared to isoform A2.
      Source sequence(s)
      AB187580, AB193058, BG530826
      Consensus CDS
      CCDS46771.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000394625, OTTHUMP00000208165, ENST00000419233, OTTHUMT00000340494
      Conserved Domains (2) summary
      pfam07557
      Location:219 – 244
      Blast Score: 106
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 124
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    5. NM_001012413.2 → NP_001012413.1  shugoshin-like 1 isoform C1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C1) lacks an in-frame internal exon and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (C1, also known as 1AB) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB193056, AC099057, AF308299, BG530826
      Consensus CDS
      CCDS46772.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000404562, ENST00000429446
      Conserved Domains (2) summary
      pfam07557
      Location:202 – 227
      Blast Score: 105
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 117
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    6. NM_001199251.1 → NP_001186180.1  shugoshin-like 1 isoform A1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A3) has an alternate 5' UTR exon, lacks the 3' exon and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (A1, also know as L1) has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB190994, AC099057, AF308299, DB163747
      Consensus CDS
      CCDS46773.1
      UniProtKB/TrEMBL
      B5BUA4
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000410458, OTTHUMP00000207982, ENST00000412997, OTTHUMT00000340012
      Conserved Domains (2) summary
      pfam07557
      Location:471 – 496
      Blast Score: 110
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 125
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    7. NM_001199252.1 → NP_001186181.1  shugoshin-like 1 isoform A2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A4) has an alternate 5' UTR exon, and encodes the same isoform A2, also known as isoform 1EF, as compared to variant A2.
      Source sequence(s)
      AB187578, AB193060, DB163747
      Consensus CDS
      CCDS33716.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000414129, OTTHUMP00000208170, ENST00000421451, OTTHUMT00000340499
      Conserved Domains (2) summary
      pfam07557
      Location:471 – 496
      Blast Score: 109
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 128
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    8. NM_001199253.1 → NP_001186182.1  shugoshin-like 1 isoform B1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B3) has an alternate 5' UTR exon, lacks an in-frame internal segment and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (B1, also known as 1CD) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB193059, AC099057, AF308299, DB163747
      Consensus CDS
      CCDS46774.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000394613, OTTHUMP00000208164, ENST00000417364, OTTHUMT00000340493
      Conserved Domains (2) summary
      pfam07557
      Location:219 – 244
      Blast Score: 108
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 120
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    9. NM_001199254.1 → NP_001186183.1  shugoshin-like 1 isoform B2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B4) has an alternate 5' UTR exon and lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (B2, also known as 1GH) lacks an internal segment, as compared to isoform A2.
      Source sequence(s)
      AB187578, AB193062, DB163747
      Consensus CDS
      CCDS46771.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000414960, OTTHUMP00000208166, ENST00000425061, OTTHUMT00000340495
      Conserved Domains (2) summary
      pfam07557
      Location:219 – 244
      Blast Score: 106
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 124
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    10. NM_001199255.1 → NP_001186184.1  shugoshin-like 1 isoform C1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C3) has an alternate 5' UTR exon, lacks an in-frame internal exon and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (C1, also known as 1AB) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
      Source sequence(s)
      AB193056, AC099057, AF308299, DB163747
      Consensus CDS
      CCDS46772.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000394957, OTTHUMP00000208172, ENST00000442720, OTTHUMT00000340501
      Conserved Domains (2) summary
      pfam07557
      Location:202 – 227
      Blast Score: 105
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 117
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    11. NM_001199256.1 → NP_001186185.1  shugoshin-like 1 isoform C2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C4) has an alternate 5' UTR exon and lacks an in-frame internal exon, as compared to variant A2. The resulting isoform (C2) lacks an internal segment, as compared to isoform A2.
      Source sequence(s)
      AB187578, AB193065, DB163747
      Consensus CDS
      CCDS2635.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000411200, OTTHUMP00000208175, ENST00000452020, OTTHUMT00000340504
      Conserved Domains (2) summary
      pfam07557
      Location:202 – 227
      Blast Score: 104
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 121
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    12. NM_001199257.1 → NP_001186186.1  shugoshin-like 1 isoform D1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (D1) has an alternate 5' UTR exon and lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (D1, also known as 1J) lacks an internal segment, as compared to isoform A2.
      Source sequence(s)
      AB187578, AB193064, DB163747
      Consensus CDS
      CCDS56243.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000413070, OTTHUMP00000208167, ENST00000443724, OTTHUMT00000340496
      Conserved Domains (1) summary
      pfam07558
      Location:22 – 67
      Blast Score: 125
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    13. NM_138484.3 → NP_612493.1  shugoshin-like 1 isoform C2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (C2) lacks an in-frame internal exon, as compared to variant A2. The resulting isoform (C2, also known as 1KL) lacks an internal segment, as compared to isoform A2.
      Source sequence(s)
      AB187582, AB193056, BG530826
      Consensus CDS
      CCDS2635.1
      UniProtKB/Swiss-Prot
      Q5FBB7
      Related
      ENSP00000306581, OTTHUMP00000161045, ENST00000306698, OTTHUMT00000252878
      Conserved Domains (2) summary
      pfam07557
      Location:202 – 227
      Blast Score: 104
      Shugoshin_C; Shugoshin C terminus
      pfam07558
      Location:22 – 67
      Blast Score: 121
      Shugoshin_N; Shugoshin N-terminal coiled-coil region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      20202085..20227724, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      20141996..20167635, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC099057.3 (137672..163272) None
    genomic CH471055.1 EAW64307.1
      EAW64308.1
      EAW64309.1
      EAW64310.1
    mRNA AB187577.1 BAD89587.1
    mRNA AB187578.1 BAD89588.1
    mRNA AB187579.1 BAD89589.1
    mRNA AB187580.1 BAD89590.1
    mRNA AB187581.1 BAD89591.1
    mRNA AB187582.1 BAD89592.1
    mRNA AB190994.1 BAD91318.1
    mRNA AB193056.1 BAD95529.1
    mRNA AB193057.1 BAD95530.1
    mRNA AB193058.1 BAD95531.1
    mRNA AB193059.1 BAD95532.1
    mRNA AB193060.1 BAD95533.1
    mRNA AB193061.1 BAD95534.1
    mRNA AB193062.1 BAD95535.1
    mRNA AB193063.1 BAD95536.1
    mRNA AB193064.1 BAD95537.1
    mRNA AB193065.1 BAD95538.1
    mRNA AB193066.1 BAD95539.1
    mRNA AB451340.1 BAG70154.1
    mRNA AB451489.1 BAG70303.1
    mRNA AB567656.1 BAJ79291.1
    mRNA AB567657.1 BAJ79292.1
    mRNA AF308299.1 AAG48266.1
    mRNA AK024292.1 None
    mRNA AK308095.1 None
    mRNA BC001339.2 AAH01339.2
    mRNA BC017867.1 AAH17867.1
    mRNA BC032696.1 AAH32696.1
    mRNA BC039605.1 None
    mRNA BG530826.1 None
    mRNA BX648516.1 None
    mRNA DB163747.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FBB7.1 GenPept UniProtKB/Swiss-Prot:Q5FBB7
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