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SGOL1 shugoshin-like 1 (S. pombe) [ Homo sapiens (human) ]

Gene ID: 151648, updated on 13-Jan-2015
Official Symbol
SGOL1provided by HGNC
Official Full Name
shugoshin-like 1 (S. pombe)provided by HGNC
Primary source
HGNC:HGNC:25088
See related
Ensembl:ENSG00000129810; HPRD:12377; MIM:609168; Vega:OTTHUMG00000130479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGO; Sgo1; NY-BR-85
Orthologs
See SGOL1 in MapViewer
Location:
3p24.3
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (20160593..20186232, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (20202085..20227724, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 18 Neighboring gene K(lysine) acetyltransferase 2B Neighboring gene microRNA 3135a Neighboring gene SGOL1 antisense RNA 1 Neighboring gene RNA, Ro-associated Y4 pseudogene 22 Neighboring gene uncharacterized LOC101927829

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr interferes with the heterochromatin structure by displacing HP1-alpha and HP1-gamma proteins in interphase, which leads to relocalization of the centromere chromatin proteins Mis12, Sgo1, and CPC after prophase PubMed
vpr HIV-1 Vpr inhibits Sgo1 expression in spread chromosomes and prometaphase cells PubMed

Go to the HIV-1, Human Interaction Database

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
  • Oocyte meiosis, organism-specific biosystem (from KEGG)
    Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • Oocyte meiosis, conserved biosystem (from KEGG)
    Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
  • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    PLK1 signaling events, organism-specific biosystem
    PLK1 signaling events
  • Resolution of Sister Chromatid Cohesion, organism-specific biosystem (from REACTOME)
    Resolution of Sister Chromatid Cohesion, organism-specific biosystemThe resolution of sister chromatids in mitotic prometaphase involves removal of cohesin complexes from chromosomal arms, with preservation of cohesion at centromeres (Losada et al. 1998, Hauf et al. ...
  • Separation of Sister Chromatids, organism-specific biosystem (from REACTOME)
    Separation of Sister Chromatids, organism-specific biosystemWhile sister chromatids resolve in prometaphase, separating along chromosomal arms, the cohesion of sister centromeres persists until anaphase. At the anaphase onset, the anaphase promoting complex/c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14230

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
attachment of spindle microtubules to kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
centriole-centriole cohesion IDA
Inferred from Direct Assay
more info
PubMed 
centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
condensed nuclear chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
mitotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
shugoshin-like 1
Names
shugoshin-like 1
hSgo1
shugoshin 1AB protein
shugoshin 1CD protein
shugoshin 1EF protein
shugoshin 1GH protein
shugoshin 1KL protein
serologically defined breast cancer antigen NY-BR-85

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012409.2NP_001012409.1  shugoshin-like 1 isoform A1

    See proteins identical to NP_001012409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A1) lacks the 3' exon and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (A1, also known as L1) has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB187577, AC099057, AF308299, BG530826
    Consensus CDS
    CCDS46773.1
    UniProtKB/TrEMBL
    B5BUA4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus
  2. NM_001012410.3NP_001012410.1  shugoshin-like 1 isoform A2

    See proteins identical to NP_001012410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A2) and variant A4 encode the same longest isoform (A2, also known as 1EF).
    Source sequence(s)
    AB187578, AB190994, BG530826
    Consensus CDS
    CCDS33716.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Related
    ENSP00000263753, OTTHUMP00000208169, ENST00000263753, OTTHUMT00000340498
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus
  3. NM_001012411.2NP_001012411.1  shugoshin-like 1 isoform B1

    See proteins identical to NP_001012411.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B1) lacks an in-frame internal segment and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (B1, also known as 1CD) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB193058, AC099057, AF308299, BG530826
    Consensus CDS
    CCDS46774.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:219244
    Shugoshin_C; Shugoshin C terminus
  4. NM_001012412.3NP_001012412.1  shugoshin-like 1 isoform B2

    See proteins identical to NP_001012412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B2) lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (B2, also known as 1GH) lacks an internal segment, as compared to isoform A2.
    Source sequence(s)
    AB187580, AB193058, BG530826
    Consensus CDS
    CCDS46771.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Related
    ENSP00000394625, OTTHUMP00000208165, ENST00000419233, OTTHUMT00000340494
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:219244
    Shugoshin_C; Shugoshin C terminus
  5. NM_001012413.2NP_001012413.1  shugoshin-like 1 isoform C1

    See proteins identical to NP_001012413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C1) lacks an in-frame internal exon and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (C1, also known as 1AB) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB193056, AC099057, AF308299, BG530826
    Consensus CDS
    CCDS46772.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:202227
    Shugoshin_C; Shugoshin C terminus
  6. NM_001199251.1NP_001186180.1  shugoshin-like 1 isoform A1

    See proteins identical to NP_001186180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A3) has an alternate 5' UTR exon, lacks the 3' exon and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (A1, also know as L1) has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB190994, AC099057, AF308299, DB163747
    Consensus CDS
    CCDS46773.1
    UniProtKB/TrEMBL
    B5BUA4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus
  7. NM_001199252.1NP_001186181.1  shugoshin-like 1 isoform A2

    See proteins identical to NP_001186181.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A4) has an alternate 5' UTR exon, and encodes the same isoform A2, also known as isoform 1EF, as compared to variant A2.
    Source sequence(s)
    AB187578, AB193060, DB163747
    Consensus CDS
    CCDS33716.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus
  8. NM_001199253.1NP_001186182.1  shugoshin-like 1 isoform B1

    See proteins identical to NP_001186182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B3) has an alternate 5' UTR exon, lacks an in-frame internal segment and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (B1, also known as 1CD) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB193059, AC099057, AF308299, DB163747
    Consensus CDS
    CCDS46774.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:219244
    Shugoshin_C; Shugoshin C terminus
  9. NM_001199254.1NP_001186183.1  shugoshin-like 1 isoform B2

    See proteins identical to NP_001186183.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B4) has an alternate 5' UTR exon and lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (B2, also known as 1GH) lacks an internal segment, as compared to isoform A2.
    Source sequence(s)
    AB187578, AB193062, DB163747
    Consensus CDS
    CCDS46771.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:219244
    Shugoshin_C; Shugoshin C terminus
  10. NM_001199255.1NP_001186184.1  shugoshin-like 1 isoform C1

    See proteins identical to NP_001186184.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C3) has an alternate 5' UTR exon, lacks an in-frame internal exon and the 3' exon, and contains an alternate 3' segment, as compared to variant A2. The resulting isoform (C1, also known as 1AB) lacks an internal segment and has a shorter and distinct C-terminus, as compared to isoform A2.
    Source sequence(s)
    AB193056, AC099057, AF308299, DB163747
    Consensus CDS
    CCDS46772.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:202227
    Shugoshin_C; Shugoshin C terminus
  11. NM_001199256.1NP_001186185.1  shugoshin-like 1 isoform C2

    See proteins identical to NP_001186185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C4) has an alternate 5' UTR exon and lacks an in-frame internal exon, as compared to variant A2. The resulting isoform (C2) lacks an internal segment, as compared to isoform A2.
    Source sequence(s)
    AB187578, AB193065, DB163747
    Consensus CDS
    CCDS2635.1
    UniProtKB/TrEMBL
    A0A024R2J4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:202227
    Shugoshin_C; Shugoshin C terminus
  12. NM_001199257.1NP_001186186.1  shugoshin-like 1 isoform D1

    See proteins identical to NP_001186186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D1) has an alternate 5' UTR exon and lacks an in-frame internal segment, as compared to variant A2. The resulting isoform (D1, also known as 1J) lacks an internal segment, as compared to isoform A2.
    Source sequence(s)
    AB187578, AB193064, DB163747
    Consensus CDS
    CCDS56243.1
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (1) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
  13. NM_138484.3NP_612493.1  shugoshin-like 1 isoform C2

    See proteins identical to NP_612493.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C2) lacks an in-frame internal exon, as compared to variant A2. The resulting isoform (C2, also known as 1KL) lacks an internal segment, as compared to isoform A2.
    Source sequence(s)
    AB187582, AB193056, BG530826
    Consensus CDS
    CCDS2635.1
    UniProtKB/TrEMBL
    A0A024R2J4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Related
    ENSP00000306581, OTTHUMP00000161045, ENST00000306698, OTTHUMT00000252878
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:202227
    Shugoshin_C; Shugoshin C terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    20160593..20186232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712986.1XP_006713049.1  

    See proteins identical to XP_006713049.1

    UniProtKB/TrEMBL
    B5BUA4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus
  2. XM_006712987.1XP_006713050.1  

    See proteins identical to XP_006713050.1

    UniProtKB/TrEMBL
    B5BUA4
    UniProtKB/Swiss-Prot
    Q5FBB7
    Conserved Domains (2) summary
    pfam07558
    Location:2267
    Shugoshin_N; Shugoshin N-terminal coiled-coil region
    pfam07557
    Location:471496
    Shugoshin_C; Shugoshin C terminus

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    20153920..20179582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    20141996..20167635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)