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Hcfc1 host cell factor C1 [ Mus musculus (house mouse) ]

Gene ID: 15161, updated on 28-May-2016
Official Symbol
Hcfc1provided by MGI
Official Full Name
host cell factor C1provided by MGI
Primary source
MGI:MGI:105942
See related
Ensembl:ENSMUSG00000031386 Vega:OTTMUSG00000017652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HCF; HCF1; AW060991
Summary
This gene encodes a transcription cofactor that regulates the progression of cell cycle and maintain the ability of embryonic stem cells to self-renew. The encoded protein is a large precursor that undergoes site-specific proteolytic cleavage to yield N- and C-terminal chains that form a non-covalent heterodimer. The encoded protein has been implicated in the regulation of expression of immediate early genes after herpes simplex virus infection and glucose-stimulated secretion of insulin by pancreatic beta cells. [provided by RefSeq, Aug 2015]
Orthologs
Location:
X 37.52 cM; X C1
Exon count:
26
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (73942792..73967135, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71188134..71211654, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene renin binding protein Neighboring gene predicted gene 8545 Neighboring gene interleukin-1 receptor-associated kinase 1 Neighboring gene microRNA 5132

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chromatin modification IEA
Inferred from Electronic Annotation
more info
 
histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein complex assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
release from viral latency IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex ISO
Inferred from Sequence Orthology
more info
 
MLL1 complex ISO
Inferred from Sequence Orthology
more info
 
MLL5-L complex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with SAGA-type complex ISO
Inferred from Sequence Orthology
more info
 
Set1C/COMPASS complex ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
host cell factor 1
Names
VP16 accessory protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008224.4NP_032250.2  host cell factor 1 precursor

    See identical proteins and their annotated locations for NP_032250.2

    Status: REVIEWED

    Source sequence(s)
    AL672002
    Consensus CDS
    CCDS30218.1
    UniProtKB/Swiss-Prot
    Q61191
    Related
    ENSMUSP00000033761, OTTMUSP00000019239, ENSMUST00000033761, OTTMUST00000042850
    Conserved Domains (6) summary
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:18661895
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:91145
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:318359
    Kelch_5; Kelch motif
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    73942792..73967135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527836.1XP_006527899.1  

    Conserved Domains (7) summary
    PHA03255
    Location:683823
    PHA03255; BDLF3; Provisional
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:19101939
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:91145
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:318359
    Kelch_5; Kelch motif
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]
  2. XM_006527835.1XP_006527898.1  

    UniProtKB/TrEMBL
    B1AUX2
    Related
    ENSMUSP00000110012, OTTMUSP00000023005, ENSMUST00000114372, OTTMUST00000043839
    Conserved Domains (7) summary
    PHA03255
    Location:683823
    PHA03255; BDLF3; Provisional
    PLN02153
    Location:12330
    PLN02153; epithiospecifier protein
    cd00063
    Location:19111940
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam01344
    Location:3269
    Kelch_1; Kelch motif
    pfam13415
    Location:91145
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:318359
    Kelch_5; Kelch motif
    sd00038
    Location:200253
    Kelch; KELCH repeat [structural motif]

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    65195174..65218749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)