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    GPBAR1 G protein-coupled bile acid receptor 1 [ Homo sapiens ]

    Gene ID: 151306, updated on 11-May-2012
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    Summary

    Official Symbol
    GPBAR1provided by HGNC
    Official Full Name
    G protein-coupled bile acid receptor 1provided by HGNC
    Primary source
    HGNC:19680
    See related
    Ensembl:ENSG00000179921; HPRD:17050; MIM:610147; Vega:OTTHUMG00000155203
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BG37; TGR5; M-BAR; GPCR19; GPR131; MGC40597
    Summary
    This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    2q35
    Sequence :
    Chromosome: 2; NC_000002.11 (219125738..219128582)
    See GPBAR1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 pseudogene 9 Neighboring gene actin related protein 2/3 complex, subunit 2, 34kDa Neighboring gene angio-associated, migratory cell protein Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesigenic dyskinesia

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders. Camilleri M, et al. Neurogastroenterol Motil, 2011 Nov. PMID 21883702.
    2. TGR5: a novel target for weight maintenance and glucose metabolism. Chen X, et al. Exp Diabetes Res, 2011. PMID 21754919.
    3. TGR5 sequence variation in primary sclerosing cholangitis. Hov JR, et al. Dig Dis, 2011. PMID 21691110.
    4. TGR5 in the biliary tree. Keitel V, et al. Dig Dis, 2011. PMID 21691103.
    5. The bile acid membrane receptor TGR5: a valuable metabolic target. Pols TW, et al. Dig Dis, 2011. PMID 21691102.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that variation in bile acid receptor TGR5 may contribute to altered small bowel transit and colonic transit in lower functional gastrointestinal disorders.
      Title: Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders.
    2. TGR5 is a key factor in energy expenditure by regulating metabolism.
      Title: TGR5: a novel target for weight maintenance and glucose metabolism.
    3. The TGR5 gene is localized at chromosome 2q35, close to a genetic variant associated with both primary sclerosing cholangitis and ulcerative colitis in recent genome-wide association studies.
      Title: TGR5 sequence variation in primary sclerosing cholangitis.
    4. The aim of the present study was to determine the localization and function of the receptor in biliary epithelial cells.
      Title: TGR5 in the biliary tree.
    5. The current knowledge on BA receptors is reviewed, with a strong focus on the cell membrane receptor TGR5, which has emerged as a promising target for intervention in metabolic diseases.
      Title: The bile acid membrane receptor TGR5: a valuable metabolic target.
    6. The ability of the bile acid analogues obtained by chemical modification of ursodeoxycholic acid (UDCA) for TGR5 activation in HEK 293 cells is reported.
      Title: Effects of chemical modification of ursodeoxycholic acid on TGR5 activation.
    7. The TGR5 is localized in the primary cilium of human cholangiocytes and the receptor could play an important role in coupling biliary bile acid concentration and composition to ductular bile formation.
      Title: The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes.
    8. resequencing of TGR5 along with functional investigations of novel variants
      Title: Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association analysis in primary sclerosing cholangitis.
    10. TGR5 signaling pathway is critical in regulating intestinal glucagon-like peptide-1 secretion in CHO cells transiently transfected hTGR5 gene.
      Title: TGR5-mediated bile acid sensing controls glucose homeostasis.
    Submit: New GeneRIF Correction See all (18)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    G-protein coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    G-protein coupled bile acid receptor 1
    Names
    G-protein coupled bile acid receptor 1
    hBG37
    hGPCR19
    membrane bile acid receptor
    G-protein coupled receptor GPCR19
    membrane-type receptor for bile acids
    G-protein coupled bile acid receptor BG37
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077191.1 → NP_001070659.1  G-protein coupled bile acid receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625
      Consensus CDS
      CCDS46515.1
      UniProtKB/TrEMBL
      B3KV35
      UniProtKB/Swiss-Prot
      Q8TDU6
      Related
      ENSP00000430886, OTTHUMP00000225874, ENST00000522678, OTTHUMT00000338767

    2. NM_001077194.1 → NP_001070662.1  G-protein coupled bile acid receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625, BI834364
      Consensus CDS
      CCDS46515.1
      UniProtKB/TrEMBL
      B3KV35
      UniProtKB/Swiss-Prot
      Q8TDU6
      Related
      ENSP00000428824, OTTHUMP00000225876, ENST00000521462, OTTHUMT00000338769

    3. NM_170699.2 → NP_733800.1  G-protein coupled bile acid receptor 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AC021016, AK122660, BC033625
      Consensus CDS
      CCDS46515.1
      UniProtKB/TrEMBL
      B3KV35
      UniProtKB/Swiss-Prot
      Q8TDU6
      Related
      ENSP00000430202, OTTHUMP00000225875, ENST00000519574, OTTHUMT00000338768

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      219125738..219128582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      210978835..210981679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB083601.1 BAB89314.1
    genomic AC021016.5 (6903..9732) None
    genomic CH471063.1 EAW70598.1
    genomic FJ695195.1 None
    mRNA AB086170.1 BAC65343.1
    mRNA AB089307.1 BAC55235.1
    mRNA AK122658.1 BAG53647.1
    mRNA AK122660.1 BAG53648.1
    mRNA BC033625.1 AAH33625.1
    mRNA BI834364.1 None
    other-genetic DQ891340.2 ABM82266.1
    other-genetic DQ894522.2 ABM85448.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDU6.1 GenPept UniProtKB/Swiss-Prot:Q8TDU6
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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