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GPBAR1 G protein-coupled bile acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 151306, updated on 7-May-2016
Official Symbol
GPBAR1provided by HGNC
Official Full Name
G protein-coupled bile acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:19680
See related
Ensembl:ENSG00000179921 HPRD:17050; MIM:610147; Vega:OTTHUMG00000155203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BG37; TGR5; M-BAR; GPCR19; GPR131
Summary
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2q35
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (218259496..218263861)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219125738..219128582)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928487 Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene transfer RNA-Tyr (ATA) 1-1 Neighboring gene angio associated migratory cell protein Neighboring gene paroxysmal nonkinesigenic dyskinesia Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene microRNA 6513

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC40597

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled bile acid receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
bile acid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface bile acid receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
regulation of bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
G-protein coupled bile acid receptor 1
Names
G-protein coupled bile acid receptor BG37
G-protein coupled receptor GPCR19
membrane bile acid receptor
membrane-type receptor for bile acids

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077191.1NP_001070659.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_001070659.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    Q8TDU6
    Related
    ENSP00000430886, OTTHUMP00000225874, ENST00000522678, OTTHUMT00000338767
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001077194.1NP_001070662.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_001070662.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625, BI834364
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    Q8TDU6
    Related
    ENSP00000428824, OTTHUMP00000225876, ENST00000521462, OTTHUMT00000338769
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001321950.1NP_001308879.1  G-protein coupled bile acid receptor 1

    Status: REVIEWED

    Source sequence(s)
    AC021016, AK122658, BC033625
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_170699.2NP_733800.1  G-protein coupled bile acid receptor 1

    See identical proteins and their annotated locations for NP_733800.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC021016, AK122660, BC033625
    Consensus CDS
    CCDS46515.1
    UniProtKB/Swiss-Prot
    Q8TDU6
    Related
    ENSP00000430202, OTTHUMP00000225875, ENST00000519574, OTTHUMT00000338768
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    218259496..218263861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510743.1XP_011509045.1  

    See identical proteins and their annotated locations for XP_011509045.1

    UniProtKB/Swiss-Prot
    Q8TDU6
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011510744.1XP_011509046.1  

    UniProtKB/Swiss-Prot
    Q8TDU6
    Related
    ENSP00000430698, OTTHUMP00000225873, ENST00000479077, OTTHUMT00000338766
    Conserved Domains (1) summary
    pfam00001
    Location:109249
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    219132227..219135071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)