ZSWIM2 zinc finger, SWIM-type containing 2 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ZSWIM2provided by HGNC
Official Full Name: zinc finger, SWIM-type containing 2provided by HGNC
Primary source: HGNC:30990
See related: Ensembl:ENSG00000163012; HPRD:15902; Vega:OTTHUMG00000154259
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MEX; ZZZ2; MGC33890

Help top of page

Genomic context

Location :: 2q32.1

Sequence :: Chromosome: 2; NC_000002.11 (187692207..187713897, complement)

See ZSWIM2 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q8NEG5	P43364	MAGEA11	HPRD	PubMed
BioGRID:127342	BioGRID:110284	MAGEA11	BioGRID	PubMed	Two-hybrid
BioGRID:127342	BioGRID:113164	UBC	BioGRID	PubMed	Reconstituted Complex
BioGRID:127342	BioGRID:127156	UBE2U	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein self-association	IEA Inferred from Electronic Annotation more info
ubiquitin-protein ligase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
protein polyubiquitination	IEA Inferred from Electronic Annotation more info
regulation of apoptotic process	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase ZSWIM2

Names: E3 ubiquitin-protein ligase ZSWIM2; MEKK1-related protein X; zinc finger, SWIM domain containing 2; ZZ-type zinc finger-containing protein 2; zinc finger SWIM domain-containing protein 2

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182521.2 → NP_872327.2 E3 ubiquitin-protein ligase ZSWIM2

Status: VALIDATED

Source sequence(s)

AK128006, BC031094

Consensus CDS

CCDS33348.1

UniProtKB/Swiss-Prot

Q8NEG5

Related

ENSP00000295131, OTTHUMP00000205380, ENST00000295131, OTTHUMT00000334565

Conserved Domains (3) summary

cd02338
Location:232 – 265
Blast Score: 123

ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...

cl15348
Location:343 – 384
Blast Score: 114

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl15408
Location:54 – 86
Blast Score: 78

SWIM; SWIM zinc finger

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

187692207..187713897, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

179552221..179573906, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC018735.12	AAY14907.1
genomic	AC103914.4	AAX82016.1
genomic	CH471058.2	EAX10929.1
genomic	HC007394.1	CBH19502.1
mRNA	AK128006.1	BAG54618.1
mRNA	BC031094.1	AAH31094.1
other-genetic	JF432747.1	ADZ15964.1