CTPS1 CTP synthase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: CTPS1provided by HGNC
Official Full Name: CTP synthase 1provided by HGNC
Primary source: HGNC:2519
See related: Ensembl:ENSG00000171793; HPRD:00465; MIM:123860; Vega:OTTHUMG00000005712
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CTPS
Summary: The catalytic conversion of UTP to CTP is accomplished by the enzyme cytidine-5-prime-triphosphate synthetase. The enzyme is important in the biosynthesis of phospholipids and nucleic acids, and plays a key role in cell growth, development, and tumorigenesis. The region to which the CTPS gene has been mapped is the location of breakpoints involved in several tumor types [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1p34.1

Sequence :: Chromosome: 1; NC_000001.10 (41445007..41478235)

See CTPS1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

analysis of the kinetic properties of hCTPS1 and hCTPS2, and determination that Ser(68) is a major site of CTPS2 regulation by phosphorylation
Title: Regulation of human cytidine triphosphate synthetase 2 by phosphorylation.
studies provide novel information on the potential interacting proteins that may regulate CTPS1 function or intracellular localization
Title: Human cytidine triphosphate synthetase 1 interacting proteins.
analysis of phosphorylation and regulation of human CTPS1 in human cells shows that GSK3 is a novel regulator of CTPS activity
Title: Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3.
Data indicate that protein kinase C phosphorylation at Ser(462) stimulates human CTP synthetase 1 activity, whereas phosphorylation at Thr(455) inhibits activity.
Title: Phosphorylation of human CTP synthetase 1 by protein kinase C: identification of Ser(462) and Thr(455) as major sites of phosphorylation.
CTP synthetase is phosphorylated by protein kinase A
Title: Expression of Human CTP synthetase in Saccharomyces cerevisiae reveals phosphorylation by protein kinase A.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P17812	P61981	YWHAG	HPRD	PubMed
BioGRID:107883	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107883	BioGRID:111822	RAD21	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107883	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107883	BioGRID:113041	TRAF6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107883	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107883	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
CTP synthase activity	EXP Inferred from Experiment more info
CTP synthase activity	IDA Inferred from Direct Assay more info	PubMed
CTP synthase activity	IGI Inferred from Genetic Interaction more info	PubMed
ligase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
CTP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
glutamine metabolic process	IEA Inferred from Electronic Annotation more info
nucleobase-containing compound metabolic process	TAS Traceable Author Statement more info	PubMed
nucleobase-containing small molecule interconversion	TAS Traceable Author Statement more info
nucleobase-containing small molecule metabolic process	TAS Traceable Author Statement more info
pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
response to drug	TAS Traceable Author Statement more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
cytosol	TAS Traceable Author Statement more info

General protein information

Preferred Names: CTP synthase 1

Names: CTP synthase 1; CTP synthetase 1; UTP--ammonia ligase 1; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase

NP_001896.2

EC 6.3.4.2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001905.2 → NP_001896.2 CTP synthase 1

Status: VALIDATED

Source sequence(s)

BC009408, BQ642049, X52142

Consensus CDS

CCDS459.1

UniProtKB/Swiss-Prot

P17812

Related

ENSP00000361704, OTTHUMP00000006322, ENST00000372621, OTTHUMT00000015629

Conserved Domains (3) summary

cd03113
Location:26 – 262
Blast Score: 854

CTGs; CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent ...

cd01746
Location:299 – 544
Blast Score: 1018

GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase

PLN02327
Location:1 – 556
Blast Score: 2164

PLN02327; CTP synthase

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

41445007..41478235

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

39562096..39595318

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL391730.13	CAH72797.1
genomic	CH471059.2	EAX07192.1
		EAX07193.1
mRNA	AK130549.1	None
mRNA	AK225899.1	None
mRNA	AK297386.1	BAG59827.1
mRNA	AK299122.1	BAG61176.1
mRNA	AK303797.1	BAG64752.1
mRNA	AK304817.1	BAH14260.1
mRNA	BC009408.1	AAH09408.1
mRNA	BQ642049.1	None
mRNA	X52142.1	CAA36386.1