SIK1 salt-inducible kinase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: SIK1provided by HGNC
Official Full Name: salt-inducible kinase 1provided by HGNC
Primary source: HGNC:11142
See related: Ensembl:ENSG00000142178; HPRD:09301; MIM:605705; Vega:OTTHUMG00000086874
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MSK; SIK; SNF1LK

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Genomic context

Location :: 21q22.3

Sequence :: Chromosome: 21; NC_000021.8 (44834395..44847002, complement)

See SIK1 in Epigenomics, MapViewer

Chromosome 21 - NC_000021.8 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results provide evidence that SIK1 is present in lung epithelial cells and that its function is relevant for the action of isoproterenol during regulation of active sodium transport.
Title: Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.
activation of the RhoA-ROCK-p38MAPK-MSK signaling pathway is essential for the regulation of the phenotype and of the CST5/cystatin D candidate tumor suppressor and other target genes by 1,25(OH)2D3 in colon cancer cells
Title: The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
SIK1 links LKB1 to p53-dependent anoikis and suppresses metastasis.
Title: SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis.
part of a cell sodium-sensing network controlling active sodium transport
Title: SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process.
SIK is a negative regulator that controls TGFbeta receptor turnover and physiological signaling.
Title: TGFbeta induces SIK to negatively regulate type I receptor kinase signaling.
the basic leucine zipper domain has a role in the regulation of transcriptional activity of CREB with TORC and salt inducible kinase [review]
Title: TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P57059	Transducer of regulated cAMP response element binding protein 2	CRTC2	HPRD	PubMed
P57059	Q9P0L0	VAPA	HPRD	PubMed
P57059	P63104	YWHAZ	HPRD	PubMed
BioGRID:127260	BioGRID:111549	PRKAA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:127260	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:127260	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	ISS Inferred from Sequence or Structural Similarity more info
cAMP response element binding protein binding	ISS Inferred from Sequence or Structural Similarity more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
cardiac muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
cell cycle	IEA Inferred from Electronic Annotation more info
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
intracellular protein kinase cascade	ISS Inferred from Sequence or Structural Similarity more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of CREB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of gluconeogenesis	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of triglyceride biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
regulation of sodium ion transport	ISS Inferred from Sequence or Structural Similarity more info
signal transduction by p53 class mediator resulting in induction of anoikis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: serine/threonine-protein kinase SIK1

Names: serine/threonine-protein kinase SIK1; SIK-1; SNF1-like kinase; myocardial SNF1-like kinase; salt-inducible protein kinase 1; serine/threonine protein kinase; serine/threonine-protein kinase SNF1LK; serine/threonine-protein kinase SNF1-like kinase 1

NP_775490.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173354.3 → NP_775490.2 serine/threonine-protein kinase SIK1

Status: VALIDATED

Source sequence(s)

AB047786

Consensus CDS

CCDS33575.1

UniProtKB/Swiss-Prot

P57059

Related

ENSP00000270162, OTTHUMP00000109458, ENST00000270162, OTTHUMT00000195654

Conserved Domains (2) summary

smart00220
Location:27 – 278
Blast Score: 861

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl09925
Location:27 – 272
Blast Score: 680

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000021.8 Reference GRCh37.p5 Primary Assembly

Range

44834395..44847002, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000153.1 Alternate HuRef

Range

30202979..30223345, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP001046.1 (147131..158062)	None
genomic	AP001047.1 (2890..4571)	None
genomic	AP001751.1	BAA95536.1
genomic	CH471079.2	EAX09495.1
		EAX09496.1
mRNA	AB047786.1	BAD74070.1
mRNA	AI073528.1	None
mRNA	AK131076.1	BAC85126.1
mRNA	BC038504.1	AAH38504.1
mRNA	BM840872.1	None
mRNA	CF528907.1	None
other-genetic	DQ892466.2	ABM83392.1
other-genetic	DQ895679.2	ABM86605.1