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SIK1 salt inducible kinase 1 [ Homo sapiens (human) ]

Gene ID: 150094, updated on 26-May-2016
Official Symbol
SIK1provided by HGNC
Official Full Name
salt inducible kinase 1provided by HGNC
Primary source
HGNC:HGNC:11142
See related
Ensembl:ENSG00000142178 HPRD:09301; MIM:605705; Vega:OTTHUMG00000086874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MSK; SIK; EIEE30; SNF1LK
Orthologs
Location:
21q22.3
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (43414509..43427126, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (44834395..44847002, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC400870 Neighboring gene uncharacterized LOC105377137 Neighboring gene long intergenic non-protein coding RNA 319 Neighboring gene uncharacterized LOC102723380 Neighboring gene long intergenic non-protein coding RNA 313

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of salt-inducible kinase 1 (SIK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystem (from REACTOME)
    BMAL1:CLOCK,NPAS2 activates circadian gene expression, organism-specific biosystemAs inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP response element binding protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cardiac muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of CREB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of myotube differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase SIK1
Names
SIK-1
SNF1-like kinase
myocardial SNF1-like kinase
salt-inducible kinase 1
salt-inducible protein kinase 1
serine/threonine protein kinase
serine/threonine-protein kinase SNF1-like kinase 1
serine/threonine-protein kinase SNF1LK
NP_775490.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173354.3NP_775490.2  serine/threonine-protein kinase SIK1

    See identical proteins and their annotated locations for NP_775490.2

    Status: VALIDATED

    Source sequence(s)
    AB047786
    Consensus CDS
    CCDS33575.1
    UniProtKB/Swiss-Prot
    P57059
    Related
    ENSP00000270162, OTTHUMP00000109458, ENST00000270162, OTTHUMT00000195654
    Conserved Domains (3) summary
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14408
    Location:300349
    UBA_SIK1; UBA domain found in salt-inducible kinase 1 (SIK1)
    cd14071
    Location:26278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    43414509..43427126 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529474.1XP_011527776.1  

    Conserved Domains (2) summary
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14071
    Location:26278
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases