CTNND1 catenin (cadherin-associated protein), delta 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CTNND1provided by HGNC
Official Full Name: catenin (cadherin-associated protein), delta 1provided by HGNC
Primary source: HGNC:2515
See related: Ensembl:ENSG00000198561; HPRD:03026; MIM:601045; Vega:OTTHUMG00000167272
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
Summary: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Genomic context

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Location :: 11q11

Sequence :: Chromosome: 11; NC_000011.9 (57529234..57586652)

See CTNND1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Suggest pivotal role of miR-197 in the regulation of p120 catenin in invasive ductal adenocarcinoma.
Title: miR-197 induces epithelial-mesenchymal transition in pancreatic cancer cells by targeting p120 catenin.
Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions.
Title: Neural Wiskott-Aldrich syndrome protein (N-WASP)-mediated p120-catenin interaction with Arp2-Actin complex stabilizes endothelial adherens junctions.
prostate cancer CWR22Rv-1 cells overexpressing delta-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay.
Title: δ-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF.
Identify MUC1-CT and p120ctn as important regulators of epithelial polarity and cell-cell adhesion during a smoke-induced epithelial mesenchymal transition-like process.
Title: Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1.
High cytoplasmic p120ctn expression is associated with thymoma.
Title: Expression of P120 catenin, Kaiso, and metastasis tumor antigen-2 in thymomas.
results reveal the mechanistic basis by which p120 stabilizes cadherins and demonstrate that VE-cadherin endocytosis is crucial for endothelial cell migration in response to an angiogenic growth factor.
Title: p120-catenin binding masks an endocytic signal conserved in classical cadherins.
P120ctn isoform 3A increased the invasiveness in all four cell lines.
Title: N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin.
FRMD5 may play a role in p120-catenin-based cell-cell contact and is involved in the regulation of tumor progression
Title: FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression.
study presents evidence that in the cadherin-catenin complex alpha-catenin contributes to the binding strength of another catenin, p120, to the same complex; data suggest alpha-catenin-p120 contact within the cadherin-catenin complex can regulate cadherin trafficking
Title: α-Catenin contributes to the strength of E-cadherin-p120 interactions.
p120 overexpression inhibits neutrophil migration independently of an effect on RhoA or Rac and instead blocks migration by preventing VE-cadherin tyrosine phosphorylation and association of active Src with the VE-cadherin complex
Title: p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.

Submit: New GeneRIF Correction See all (102)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AAC39822.1	NP_004351.1	CDH1	BIND	PubMed	CDH1(Ecad) interacts with P120ctn 3AC. This interaction was modelled on a demonstrated interaction between mouse CDH1(Ecad) and human P120ctn 3AC.
O60716	P68133	ACTA1	HPRD	PubMed
O60716	P12830	CDH1	HPRD	PubMed
O60716	Q86UP0	CDH24	HPRD	PubMed
O60716	P22223	CDH3	HPRD	PubMed
O60716	P33151	CDH5	HPRD	PubMed
O60716	Q9UMD9	COL17A1	HPRD	PubMed
O60716	O60716	CTNND1	HPRD	PubMed
O60716	Q14247	CTTN	HPRD	PubMed
O60716	P00533	EGFR	HPRD	PubMed
O60716	Q96RT1	ERBB2IP	HPRD	PubMed
O60716	P16591	FER	HPRD	PubMed
O60716	Q13002	GRIK2	HPRD	PubMed
O60716	P49841	GSK3B	HPRD	PubMed
O60716	P14923	JUP	HPRD	PubMed
O60716	P49286	MTNR1B	HPRD	PubMed
O60716	P15941	MUC1	HPRD	PubMed
O60716	P49768	PSEN1	HPRD	PubMed
O60716	P29350	PTPN6	HPRD	PubMed
O60716	Q12913	PTPRJ	HPRD	PubMed
O60716	P28827	PTPRM	HPRD	PubMed
O60716	P12931	SRC	HPRD	PubMed
O60716	P61981	YWHAG	HPRD	PubMed
O60716	Q86T24	ZBTB33	HPRD	PubMed
BioGRID:107881	BioGRID:106586	ACTG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107881	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:107776	ATF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Co-localization; Reconstituted Complex; Two-hybrid
BioGRID:107881	BioGRID:107435	CDH2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107881	BioGRID:107436	CDH3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:107438	CDH5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:107704	COL17A1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:107881	BioGRID:107838	CSNK1E	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:107876	CTNNA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:108332	CTTN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107881	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:108276	EGFR	BioGRID	PubMed	Reconstituted Complex
BioGRID:107881	BioGRID:120997	ERBB2IP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107881	BioGRID:108810	FYN	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107881	BioGRID:110124	LCK	BioGRID	PubMed	Biochemical Activity
BioGRID:107881	BioGRID:110669	MUC1	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:107881	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:111642	PSEN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107881	BioGRID:111742	PTPN6	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107881	BioGRID:111759	PTPRJ	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107881	BioGRID:111761	PTPRM	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107881	BioGRID:116224	RIPK3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:112506	SNCA	BioGRID	PubMed	Reconstituted Complex
BioGRID:107881	BioGRID:114397	SQSTM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex
BioGRID:107881	BioGRID:113258	VCP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:121649	WDR48	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107881	BioGRID:113357	YES1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107881	BioGRID:115327	ZBTB33	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid

Pathways from BioSystems

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Adherens junction, organism-specific biosystem (from KEGG)
Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junction, conserved biosystem (from KEGG)
Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
Adherens junctions interactions, organism-specific biosystem (from REACTOME)
Adherens junctions interactions, organism-specific biosystemThe adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (...
Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
Arf6 trafficking events, organism-specific biosystem
Arf6 trafficking events
Cell junction organization, organism-specific biosystem (from REACTOME)
Cell junction organization, organism-specific biosystem
Cell junction organization
Cell-Cell communication, organism-specific biosystem (from REACTOME)
Cell-Cell communication, organism-specific biosystemCell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell cont...
Cell-cell junction organization, organism-specific biosystem (from REACTOME)
Cell-cell junction organization, organism-specific biosystemEpithelial cell-cell contacts consist of three major adhesion systems: adherens junctions (AJs), tight junctions (TJs), and desmosomes. These adhesion systems differ in their function and compositio...
E-cadherin signaling in keratinocytes, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in keratinocytes, organism-specific biosystem
E-cadherin signaling in keratinocytes
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem (from Pathway Interaction Database)
E-cadherin signaling in the nascent adherens junction, organism-specific biosystem
E-cadherin signaling in the nascent adherens junction
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
FGF signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
FGF signaling pathway, organism-specific biosystem
FGF signaling pathway
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
N-cadherin signaling events, organism-specific biosystem (from Pathway Interaction Database)
N-cadherin signaling events, organism-specific biosystem
N-cadherin signaling events
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
Stabilization and expansion of the E-cadherin adherens junction
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...

General gene information

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Markers

D11S4004 (e-PCR)
- UniSTS:19071

GDB:451855 (e-PCR)
- UniSTS:157384

RH47458 (e-PCR)
- UniSTS:51418

STS-H97485 (e-PCR)
- UniSTS:63219

Genotypes

See CTNND1 SNP Geneview Report
See CTNND1 SNP Genotype Report
See CTNND1 SNP Variation Viewer Report

Readthrough TMX2-CTNND1

Readthrough gene: TMX2-CTNND1, Included gene: TMX2

Homology

Homologs of the CTNND1 gene: The CTNND1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info
protein phosphatase binding	IEA Inferred from Electronic Annotation more info
receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
adherens junction organization	TAS Traceable Author Statement more info
cell adhesion	NAS Non-traceable Author Statement more info	PubMed
cell junction assembly	TAS Traceable Author Statement more info
cell-cell adhesion	IEA Inferred from Electronic Annotation more info
cell-cell junction organization	TAS Traceable Author Statement more info
epithelial cell differentiation involved in salivary gland development	IEA Inferred from Electronic Annotation more info
keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
morphogenesis of a polarized epithelium	IEA Inferred from Electronic Annotation more info
negative regulation of canonical Wnt receptor signaling pathway	IMP Inferred from Mutant Phenotype more info
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell-cell adherens junction	IEA Inferred from Electronic Annotation more info
cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IMP Inferred from Mutant Phenotype more info
lamellipodium	IEA Inferred from Electronic Annotation more info
midbody	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info
plasma membrane	IDA Inferred from Direct Assay more info
plasma membrane	IMP Inferred from Mutant Phenotype more info
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: catenin delta-1

Names: catenin delta-1; p120 catenin; cadherin-associated Src substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029078.1 RefSeqGene

Range

5001..62419

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001085458.1 → NP_001078927.1 catenin delta-1 isoform 1ABC

Status: REVIEWED

Description

Transcript Variant: This variant (1) is the longest variant and it encodes the longest protein (isoform 1ABC). This variant has also been called hp120ctn-1ABC.

Source sequence(s)

AF062341, AI088791, BC075795, BP217375, CN431494, DB090596

Consensus CDS

CCDS44604.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000382004, OTTHUMP00000235577, ENST00000399050, OTTHUMT00000393944

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085459.1 → NP_001078928.1 catenin delta-1 isoform 1AB

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the coding region, compared to variant 1. The resulting protein (isoform 1AB) is shorter than isoform 1ABC. This variant is also called hp120ctn-1AB.

Source sequence(s)

AF062328, AI088791, BC075795, BP217375, CN431494, DB090596

Consensus CDS

CCDS44605.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000354823, OTTHUMP00000235579, ENST00000361332, OTTHUMT00000393946

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 235

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085460.1 → NP_001078929.1 catenin delta-1 isoform 1A

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses a different splice site in the 5' UTR and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 5 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062324, AI088791, AL698868, BC075795, BP217375, CN431494

Consensus CDS

CCDS44606.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000351527, OTTHUMP00000235582, ENST00000358694, OTTHUMT00000393949

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085461.1 → NP_001078930.1 catenin delta-1 isoform 1A

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 6. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062339, AI088791, BC075795, BP217375, CN431494, DB090596

Consensus CDS

CCDS44606.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000354907, ENST00000361796

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085462.1 → NP_001078931.1 catenin delta-1 isoform 1A

Status: REVIEWED

Description

Transcript Variant: This variant (6) uses a different splice site in the 5' UTR, lacks an alternate segment in the 5' UTR, and lacks two alternate in-frame segments in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-1A with variants 4 and 5. Variants 4, 5, and 6 encode the same protein (isoform 1A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062343, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS44606.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000413586, OTTHUMP00000235588, ENST00000428599, OTTHUMT00000393955

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 234

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085463.1 → NP_001078932.1 catenin delta-1 isoform 3ABC

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3ABC) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3ABC.

Source sequence(s)

AF062323, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS44608.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000403518, OTTHUMP00000235650, ENST00000415361, OTTHUMT00000394040

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 237

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085464.1 → NP_001078933.1 catenin delta-1 isoform 3AB

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3AB) has a shorter N-terminus, compared to isoform 1ABC. This variant is also called hp120ctn-3AB.

Source sequence(s)

AF062338, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS53633.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000437327, OTTHUMP00000235649, ENST00000530094, OTTHUMT00000394039

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 237

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085465.1 → NP_001078934.1 catenin delta-1 isoform 3B

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3B) is shorter when it is compared to isoform 1ABC. This variant is also called hp120ctn-3B.

Source sequence(s)

AF062332, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS53634.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000434949, OTTHUMP00000235583, ENST00000532787, OTTHUMT00000393950

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085466.1 → NP_001078935.1 catenin delta-1 isoform 3AC

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences, compared to variant 1. The resulting protein (isoform 3AC) is shorter than isoform 1ABC. This variant is also called hp120ctn-3AC.

Source sequence(s)

AF062337, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS53632.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000435266, OTTHUMP00000235590, ENST00000528232, OTTHUMT00000393957

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085467.1 → NP_001078936.1 catenin delta-1 isoform 3A

Status: REVIEWED

Description

Transcript Variant: This variant (11) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 12 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062334, AI088791, BC075795, BP217375, CN431494, DB090596

Consensus CDS

CCDS44609.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000409930, OTTHUMP00000235576, ENST00000426142, OTTHUMT00000393943

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085468.1 → NP_001078937.1 catenin delta-1 isoform 3A

Status: REVIEWED

Description

Transcript Variant: This variant (12) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 13. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062335, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS44609.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000437156, OTTHUMP00000235581, ENST00000529986, OTTHUMT00000393948

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001085469.1 → NP_001078938.1 catenin delta-1 isoform 3A

Status: REVIEWED

Description

Transcript Variant: This variant (13) lacks multiple alternate segments in the 5' UTR and in the coding region, compared to variant 1. This variant shares the alternate name of hp120ctn-3A with variants 11 and 12. Variants 11, 12, and 13 encode the same protein (isoform 3A), which is shorter than isoform 1ABC.

Source sequence(s)

AF062336, AI088791, BC075795, BP217375, CN431494

Consensus CDS

CCDS44609.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000434017, OTTHUMP00000235651, ENST00000532245, OTTHUMT00000394041

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206883.1 → NP_001193812.1 catenin delta-1 isoform 2ABC

Status: REVIEWED

Description

Transcript Variant: This variant (14) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2ABC) has a shorter N-terminus than isoform 1ABC.

Source sequence(s)

AF062319, AI079200, AP001931, BP217375

Consensus CDS

CCDS55763.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000433276, OTTHUMP00000235595, ENST00000532844, OTTHUMT00000393962

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 237

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206884.1 → NP_001193813.1 catenin delta-1 isoform 2AC

Status: REVIEWED

Description

Transcript Variant: This variant (15) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AC) is shorter than isoform 1ABC.

Source sequence(s)

AF062320, AI079200, AP001931, BP217375

Consensus CDS

CCDS55764.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000436744, OTTHUMP00000235587, ENST00000530748, OTTHUMT00000393954

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 237

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206885.1 → NP_001193814.1 catenin delta-1 isoform 1AC

Status: REVIEWED

Description

Transcript Variant: This variant (16) lacks an in-frame exon in the 3_ coding region, compared to variant 1. This results in a shorter protein (isoform 1AC), compared to isoform 1ABC).

Source sequence(s)

AF062321, AI079200, AP001931, BP217375

UniProtKB/Swiss-Prot

O60716

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 235

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206886.1 → NP_001193815.1 catenin delta-1 isoform 2AB

Status: REVIEWED

Description

Transcript Variant: This variant (17) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2AB) is shorter than isoform 1ABC.

Source sequence(s)

AF062322, AI079200, AP001931, BP217375

Consensus CDS

CCDS55765.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000433334, OTTHUMP00000235648, ENST00000526357, OTTHUMT00000394038

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 237

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206887.1 → NP_001193816.1 catenin delta-1 isoform 2B

Status: REVIEWED

Description

Transcript Variant: This variant (18) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2B) is shorter than isoform 1ABC.

Source sequence(s)

AF062325, AI079200, AP001931, BP217375

Consensus CDS

CCDS55767.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000435494, OTTHUMP00000235593, ENST00000529873, OTTHUMT00000393960

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206888.1 → NP_001193817.1 catenin delta-1 isoform 2A

Status: REVIEWED

Description

Transcript Variant: This variant (19) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AF062327, AI079200, AP001931, BP217375

Consensus CDS

CCDS55766.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000432243, OTTHUMP00000235586, ENST00000528621, OTTHUMT00000393953

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206889.1 → NP_001193818.1 catenin delta-1 isoform 2A

Status: REVIEWED

Description

Transcript Variant: This variant (20) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AF062329, AI079200, AP001931, BP217375

Consensus CDS

CCDS55766.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000435379, OTTHUMP00000235585, ENST00000532649, OTTHUMT00000393952

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206890.1 → NP_001193819.1 catenin delta-1 isoform 3A

Status: REVIEWED

Description

Transcript Variant: This variant (21) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (3A) is shorter than isoform 1ABC.

Source sequence(s)

AF062330, AI079200, AP001931, BP217375

Consensus CDS

CCDS44609.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000432075, OTTHUMP00000235580, ENST00000532463, OTTHUMT00000393947

Conserved Domains (1) summary

cd00020
Location:262 – 380
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001206891.1 → NP_001193820.1 catenin delta-1 isoform 2A

Status: REVIEWED

Description

Transcript Variant: This variant (22) differs in the 5' UTR and and has multiple coding region differences, compared to variant 1. The encoded isoform (2A) is shorter than isoform 1ABC.

Source sequence(s)

AF062331, AI079200, AP001931, BP217375

Consensus CDS

CCDS55766.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000436323, OTTHUMP00000235574, ENST00000529526, OTTHUMT00000393941

Conserved Domains (1) summary

cd00020
Location:309 – 427
Blast Score: 236

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
NM_001331.2 → NP_001322.1 catenin delta-1 isoform 1B

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two alternate in-frame segments in the coding region, compared to variant 1. The encoded protein (isoform 1B) is shorter than isoform 1ABC. Another name for this variant is hp120ctn-1B.

Source sequence(s)

AF062317, AI088791, BC075795, BP217375, CN431494, DB090596

Consensus CDS

CCDS44607.1

UniProtKB/Swiss-Prot

O60716

Related

ENSP00000354785, OTTHUMP00000235578, ENST00000361391, OTTHUMT00000393945

Conserved Domains (1) summary

cd00020
Location:363 – 481
Blast Score: 235

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

57529234..57586652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

53877613..53935179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

57449622..57507135

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01021479.1 (712..7534)	None
genomic	ABBA01021480.1	None
genomic	ABBA01021481.1	None
genomic	AMYH01003654.1 (44923..83160)	None
genomic	AMYH01003655.1	None
genomic	AP001931.5 (41853..99234)	None
genomic	AY505564.1	AAR84236.1
genomic	CH471076.1	EAW73785.1
		EAW73786.1
		EAW73787.1
		EAW73788.1
		EAW73789.1
		EAW73790.1
		EAW73791.1
		EAW73792.1
mRNA	AF062317.1	AAC39802.1
mRNA	AF062318.1	AAC39803.1
mRNA	AF062319.1	AAC39804.1
mRNA	AF062320.1	AAC39805.1
mRNA	AF062321.1	AAC39806.1
mRNA	AF062322.1	AAC39807.1
mRNA	AF062323.1	AAC39808.1
mRNA	AF062324.1	AAC39809.1
mRNA	AF062325.1	AAC39810.1
mRNA	AF062326.1	AAC39811.1
mRNA	AF062327.1	AAC39812.1
mRNA	AF062328.1	AAC39813.1
mRNA	AF062329.1	AAC39814.1
mRNA	AF062330.1	AAC39815.1
mRNA	AF062331.1	AAC39816.1
mRNA	AF062332.1	AAC39817.1
mRNA	AF062333.1	AAC39818.1
mRNA	AF062334.1	AAC39819.1
mRNA	AF062335.1	AAC39820.1
mRNA	AF062336.1	AAC39821.1
mRNA	AF062337.1	AAC39822.1
mRNA	AF062338.1	AAC39823.1
mRNA	AF062339.1	AAC39824.1
mRNA	AF062340.1	AAC39825.1
mRNA	AF062341.1	AAC39826.1
mRNA	AF062342.1	AAC39827.1
mRNA	AF062343.1	AAC39828.1
mRNA	AF062344.1	AAC39829.1
mRNA	AI079200.1	None
mRNA	AI088791.1	None
mRNA	AK292554.1	BAF85243.1
mRNA	AL698868.1	None
mRNA	BC010501.1	AAH10501.2
mRNA	BC075795.1	AAH75795.1
mRNA	BP217375.1	None
mRNA	BT007333.1	AAP35997.1
mRNA	CN431494.1	None
mRNA	CR749275.1	CAH18130.1
mRNA	DB090596.1	None