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Cfb complement factor B [ Mus musculus (house mouse) ]

Gene ID: 14962, updated on 30-May-2016
Official Symbol
Cfbprovided by MGI
Official Full Name
complement factor Bprovided by MGI
Primary source
MGI:MGI:105975
See related
Ensembl:ENSMUSG00000090231 Vega:OTTMUSG00000034004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B; Bf; C2; Fb; H2-Bf; AI195813; AI255840
Orthologs
Location:
17 B1; 17 18.41 cM
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (34856374..34862514, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34993319..34999459, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae) Neighboring gene microRNA 6970 Neighboring gene negative elongation factor complex member E, Rdbp Neighboring gene microRNA 6972 Neighboring gene complement component 2 (within H-2S) Neighboring gene predicted gene, 40706 Neighboring gene zinc finger and BTB domain containing 12

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
complement activation ISO
Inferred from Sequence Orthology
more info
 
complement activation, alternative pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
complement activation, alternative pathway TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to thyroid hormone ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
complement factor B
Names
C3/C5 convertase
Factor B
alternative-complement pathway C3/C5 convertase
complement component 2 (within H-2S)
histocompatibility 2, complement component factor B
properdin
NP_001136178.1
NP_032224.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142706.1NP_001136178.1  complement factor B isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region that results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK149573, BP766400, CA492475
    Consensus CDS
    CCDS50079.1
    UniProtKB/TrEMBL
    B8JJM6
    Related
    ENSMUSP00000135660, ENSMUST00000176203
    Conserved Domains (3) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488599
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_008198.2NP_032224.2  complement factor B isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK149531, BP766400, CA492475
    Consensus CDS
    CCDS28663.2
    UniProtKB/TrEMBL
    B8JJM5, Q3UEG8
    Related
    ENSMUSP00000025229, ENSMUST00000025229
    Conserved Domains (5) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd00190
    Location:488754
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    pfam00089
    Location:490751
    Trypsin; Trypsin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    34856374..34862514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523671.1XP_006523734.1  

    See identical proteins and their annotated locations for XP_006523734.1

    Conserved Domains (4) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006523672.2XP_006523735.1  

    See identical proteins and their annotated locations for XP_006523735.1

    Conserved Domains (3) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488599
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Reference GRCm38.p3 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p3 129X1/SvJ

    Range
    1105147..1111288 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525304.1XP_006525367.1  

    See identical proteins and their annotated locations for XP_006525367.1

    Conserved Domains (4) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_006525305.2XP_006525368.1  

    See identical proteins and their annotated locations for XP_006525368.1

    Conserved Domains (3) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488599
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    1174595..1180721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011251285.1XP_011249587.1  

    See identical proteins and their annotated locations for XP_011249587.1

    Conserved Domains (5) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd00190
    Location:487753
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01470
    Location:267464
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    pfam00089
    Location:489750
    Trypsin; Trypsin
  2. XM_011251286.1XP_011249588.1  

    See identical proteins and their annotated locations for XP_011249588.1

    Conserved Domains (4) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006537257.2XP_006537320.1  

    See identical proteins and their annotated locations for XP_006537320.1

    Conserved Domains (3) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488599
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    1174846..1180972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238141.1XP_011236443.1  

    See identical proteins and their annotated locations for XP_011236443.1

    Conserved Domains (5) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd00190
    Location:487753
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    cd01470
    Location:267464
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    pfam00089
    Location:489750
    Trypsin; Trypsin
  2. XM_011238146.1XP_011236448.1  

    See identical proteins and their annotated locations for XP_011236448.1

    Conserved Domains (4) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    smart00032
    Location:5482
    CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488695
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_006536524.2XP_006536587.1  

    See identical proteins and their annotated locations for XP_006536587.1

    Conserved Domains (3) summary
    cd00033
    Location:102157
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd01470
    Location:268465
    vWA_complement_factors; Complement factors B and C2 are two critical proteases for complement activation. They both contain three CCP or Sushi domains, a trypsin-type serine protease domain and a single VWA domain with a conserved metal ion dependent adhesion site referred ...
    cl21584
    Location:488599
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    37951682..37957822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)