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    CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa [ Homo sapiens (human) ]

    Gene ID: 1495, updated on 15-Jun-2013
    Official Symbol
    CTNNA1provided by HGNC
    Official Full Name
    catenin (cadherin-associated protein), alpha 1, 102kDaprovided by HGNC
    Primary source
    HGNC:2509
    See related
    Ensembl:ENSG00000044115; HPRD:00285; MIM:116805; Vega:OTTHUMG00000163502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAP102
    Location :
    5q31.2
    Sequence :
    Chromosome: 5; NC_000005.9 (138089107..138270723)
    See CTNNA1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 63 Neighboring gene heat shock 70kDa protein 9 (mortalin) Neighboring gene ribosomal protein L10a pseudogene 10 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene SIL1 homolog, endoplasmic reticulum chaperone (S. cerevisiae) Neighboring gene ribosomal protein L12 pseudogene 21 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 (non-protein coding) Neighboring gene matrin 3

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 and alpha-catenin co-localize in gp160 and GST-alpha-catenin expressing cells; the leucine zipper-like domain (gp160 residues 791-824) of gp41 interacts strongly with the carboxy terminus (residues 795-906) of alpha-catenin PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001894.1 NP_001895.1 CTNNB1    BIND  PubMed Beta-catenin interacts with alpha-catenin. This interaction was modelled on a demonstrated interaction between human beta-catenin and mouse alpha-catenin. 
    P35221 P12814 ACTN1    HPRD  PubMed  
    P35221 Ajuba AJUBA    HPRD  PubMed  
    P35221 Q16790 CA9    HPRD  PubMed  
    P35221 P12830 CDH1    HPRD  PubMed  
    P35221 P55291 CDH15    HPRD  PubMed  
    P35221 P19022 CDH2    HPRD  PubMed  
    P35221 P22223 CDH3    HPRD  PubMed  
    P35221 P33151 CDH5    HPRD  PubMed  
    P35221 P35222 CTNNB1    HPRD  PubMed  
    P35221 Q12959 DLG1    HPRD  PubMed  
    P35221 Q96KN1 FAM84B    HPRD  PubMed  
    P35221 P14923 JUP    HPRD  PubMed  
    P35221 P55196 MLLT4    HPRD  PubMed  
    P35221 P98161 PKD1    HPRD  PubMed  
    P35221 P49768 PSEN1    HPRD  PubMed  
    P35221 Q13813 SPTAN1    HPRD  PubMed  
    P35221 Q07157 TJP1    HPRD  PubMed  
    P35221 Q9UDY2 TJP2    HPRD  PubMed  
    P35221 P18206 VCL    HPRD  PubMed  
    BioGRID:107876 BioGRID:106602 ACTN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107876 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107876 BioGRID:117376 ARMC8    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107876 BioGRID:106902 ARRB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:107223 CA9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:107434 CDH1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107876 BioGRID:107435 CDH2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-fractionation 
    BioGRID:107876 BioGRID:107436 CDH3    BioGRID  PubMed Affinity Capture-Western; Co-purification 
    BioGRID:107876 BioGRID:107438 CDH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:107869 CTBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107876 BioGRID:107876 CTNNA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107876 BioGRID:107881 CTNND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:108332 CTTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:114031 CUL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:216476 Cep350    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:108083 DLG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:108291 EIF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:127609 FAM84B    BioGRID  PubMed Two-hybrid 
    BioGRID:107876 BioGRID:108887 GARS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:116022 HSPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:109931 JUP    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:107876 BioGRID:110447 MLLT4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107876 BioGRID:110731 MYO7A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:111048 OSBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:115491 PRMT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:111642 PSEN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:111748 PTPN14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:122736 RNF219    BioGRID  PubMed Two-hybrid 
    BioGRID:107876 BioGRID:112171 RYK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:115747 SEC23A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:112589 SPTBN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107876 BioGRID:113188 SUMO1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107876 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:114809 TJP2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107876 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:113866 USP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:113257 VCL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107876 BioGRID:113258 VCP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:120736 VEZT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107876 BioGRID:116678 XPO7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107876 BioGRID:124150 ZGPAT    BioGRID  PubMed Two-hybrid 

    Markers

    Homology

    Clone Names

    • FLJ36832, FLJ52416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    actin filament binding IEA
    Inferred from Electronic Annotation
    more info
     
    beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    gamma-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    vinculin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adherens junction organization TAS
    Traceable Author Statement
    more info
     
    aging IEA
    Inferred from Electronic Annotation
    more info
     
    apical junction assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction assembly TAS
    Traceable Author Statement
    more info
     
    cell-cell junction organization TAS
    Traceable Author Statement
    more info
     
    cellular response to indole-3-methanol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    establishment or maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    gap junction assembly IEA
    Inferred from Electronic Annotation
    more info
     
    male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    muscle cell differentiation TAS
    Traceable Author Statement
    more info
     
    negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of muscle cell differentiation TAS
    Traceable Author Statement
    more info
     
    positive regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    response to estrogen stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    catenin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    zonula adherens IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    catenin alpha-1
    Names
    catenin alpha-1
    alpha-catenin
    alphaE-catenin
    alpha E-catenin
    alpha-E-catenin
    renal carcinoma antigen NY-REN-13
    cadherin-associated protein,102kDa

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001903.2NP_001894.2  catenin alpha-1

      Status: VALIDATED

      Source sequence(s)
      AU141929, BU624488, D13866, D14705
      Consensus CDS
      CCDS34243.1
      UniProtKB/Swiss-Prot
      P35221
      Related
      ENSP00000304669, OTTHUMP00000224141, ENST00000302763, OTTHUMT00000373868
      Conserved Domains (1) summary
      pfam01044
      Location:19867
      Blast Score: 2983
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      138089107..138270723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      133278985..133460517
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      138364982..138546568
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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