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CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa [ Homo sapiens (human) ]

Gene ID: 1495, updated on 27-Sep-2014
Official Symbol
CTNNA1provided by HGNC
Official Full Name
catenin (cadherin-associated protein), alpha 1, 102kDaprovided by HGNC
Primary source
HGNC:HGNC:2509
See related
Ensembl:ENSG00000044115; HPRD:00285; MIM:116805; Vega:OTTHUMG00000163502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAP102
See CTNNA1 in Epigenomics, MapViewer
Location:
5q31.2
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (138753418..138935034)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138089075..138270723)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, C/D box 63 Neighboring gene heat shock 70kDa protein 9 (mortalin) Neighboring gene ribosomal protein L10a pseudogene 10 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene ribosomal protein L12 pseudogene 21 Neighboring gene small nucleolar RNA, H/ACA box 74A Neighboring gene small nucleolar RNA host gene 4 (non-protein coding) Neighboring gene matrin 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 and alpha-catenin co-localize in gp160 and GST-alpha-catenin expressing cells; the leucine zipper-like domain (gp160 residues 791-824) of gp41 interacts strongly with the carboxy terminus (residues 795-906) of alpha-catenin PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36832, FLJ52416

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
gamma-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
vinculin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization TAS
Traceable Author Statement
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
apical junction assembly NAS
Non-traceable Author Statement
more info
PubMed 
axon regeneration IEA
Inferred from Electronic Annotation
more info
 
cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
cell junction assembly TAS
Traceable Author Statement
more info
 
cell-cell junction organization TAS
Traceable Author Statement
more info
 
cellular protein localization IEA
Inferred from Electronic Annotation
more info
 
cellular response to indole-3-methanol IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of cell polarity IEA
Inferred from Electronic Annotation
more info
 
gap junction assembly IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
muscle cell differentiation TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell motility IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
negative regulation of integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein heterooligomerization IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
intercalated disc IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
zonula adherens IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
catenin alpha-1
Names
catenin alpha-1
alpha-catenin
alphaE-catenin
alpha E-catenin
alpha-E-catenin
renal carcinoma antigen NY-REN-13
cadherin-associated protein,102kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290307.1NP_001277236.1  catenin alpha-1 isoform 2

    See proteins identical to NP_001277236.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI078507, BC000385, DC369291, U03100
    UniProtKB/TrEMBL
    G3XAM7
    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:19811
    Vinculin; Vinculin family
  2. NM_001290309.1NP_001277238.1  catenin alpha-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (3) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI078507, AK296708, AK300439, BC000385, DC369291
    UniProtKB/TrEMBL
    B4DKT9
    UniProtKB/TrEMBL
    B4DU00
    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:1764
    Vinculin; Vinculin family
  3. NM_001290310.1NP_001277239.1  catenin alpha-1 isoform 4 precursor

    See proteins identical to NP_001277239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon and another at the 5' end of the next exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI078507, AK296708, BC000385, DC369291
    UniProtKB/TrEMBL
    B4DKT9
    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:1744
    Vinculin; Vinculin family
  4. NM_001290312.1NP_001277241.1  catenin alpha-1 isoform 5

    See proteins identical to NP_001277241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in place of the first seven exons compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (5) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AI078507, BC000385, BC031262, DA349847
    Consensus CDS
    CCDS75315.1
    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:1497
    Vinculin; Vinculin family
  5. NM_001903.3NP_001894.2  catenin alpha-1 isoform 1

    See proteins identical to NP_001894.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest isoform (1).
    Source sequence(s)
    AI078507, BC000385, DC369291
    Consensus CDS
    CCDS34243.1
    UniProtKB/Swiss-Prot
    P35221
    Related
    ENSP00000304669, OTTHUMP00000224141, ENST00000302763, OTTHUMT00000373868
    Conserved Domains (1) summary
    pfam01044
    Location:19867
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    138753418..138935034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714536.1XP_006714599.1  

    See proteins identical to XP_006714599.1

    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:19867
    Vinculin; Vinculin family
  2. XM_005271898.1XP_005271955.1  

    Related
    ENSP00000438476, ENST00000540387
    Conserved Domains (1) summary
    pfam01044
    Location:1497
    Vinculin; Vinculin family
  3. XM_005271899.1XP_005271956.1  

    See proteins identical to XP_005271956.1

    UniProtKB/Swiss-Prot
    P35221
    Conserved Domains (1) summary
    pfam01044
    Location:1497
    Vinculin; Vinculin family

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    133278985..133460517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    137521762..137703280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)