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    PDIK1L PDLIM1 interacting kinase 1 like [ Homo sapiens ]

    Gene ID: 149420, updated on 11-May-2012
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    Summary

    Official Symbol
    PDIK1Lprovided by HGNC
    Official Full Name
    PDLIM1 interacting kinase 1 likeprovided by HGNC
    Primary source
    HGNC:18981
    Locus tag
    RP11-96L14.4
    See related
    Ensembl:ENSG00000175087; HPRD:15110; MIM:610785; Vega:OTTHUMG00000007511
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLIK1L; STK35L2
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    Genomic context

    Location :
    1p36.11
    Sequence :
    Chromosome: 1; NC_000001.10 (26437656..26452034)
    See PDIK1L in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 (zinc transporter), member 2 Neighboring gene tripartite motif containing 63, E3 ubiquitin protein ligase Neighboring gene family with sequence similarity 110, member D Neighboring gene zinc finger protein 593

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140.
    3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. Human ORFeome version 1.1: a platform for reverse proteomics. Rual JF, et al. Genome Res, 2004 Oct. PMID 15489335.

    See all (10) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q8N165 P01375 TNF    HPRD  PubMed  
    BioGRID:127209 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    serine/threonine-protein kinase PDIK1L
    Names
    serine/threonine-protein kinase PDIK1L
    casein kinase
    PDLIM1-interacting kinase 1-like
    NP_690048.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243532.1 → NP_001230461.1  serine/threonine-protein kinase PDIK1L

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL834290, BU742621, CV024336, DA221039, DB233669
      UniProtKB/Swiss-Prot
      Q8N165
      Conserved Domains (2) summary
      cd00180
      Location:14 – 325
      Blast Score: 448
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:8 – 325
      Blast Score: 495
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    2. NM_001243533.1 → NP_001230462.1  serine/threonine-protein kinase PDIK1L

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AF411102, BU742621, DB227864
      UniProtKB/Swiss-Prot
      Q8N165
      Conserved Domains (2) summary
      cd00180
      Location:14 – 325
      Blast Score: 448
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:8 – 325
      Blast Score: 495
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    3. NM_152835.4 → NP_690048.1  serine/threonine-protein kinase PDIK1L

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK312872, AL834290, BU742621
      Consensus CDS
      CCDS274.1
      UniProtKB/Swiss-Prot
      Q8N165
      Related
      ENSP00000363387, OTTHUMP00000008703, ENST00000374269, OTTHUMT00000019753
      Conserved Domains (2) summary
      cd00180
      Location:14 – 325
      Blast Score: 448
      PKc; Catalytic domain of Protein Kinases
      smart00220
      Location:8 – 325
      Blast Score: 495
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      26437656..26452034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      24691580..24705955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL391650.18 CAI17134.1
      CAI17135.1
    genomic CH471059.2 EAX07845.1
      EAX07846.1
      EAX07847.1
    mRNA AF411102.1 AAN03661.1
    mRNA AK312872.1 BAG35724.1
    mRNA AL137407.1 None
    mRNA AL834290.1 CAD38964.1
    mRNA BC028713.1 AAH28713.1
    mRNA BC035401.1 None
    mRNA BU742621.1 None
    mRNA CV024336.1 None
    mRNA DA221039.1 None
    mRNA DB227864.1 None
    mRNA DB233669.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N165.1 GenPept UniProtKB/Swiss-Prot:Q8N165
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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