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    tax p40 [ Human T-lymphotropic virus 1 ]

    Gene ID: 1491938, updated on 5-May-2012
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    Summary

    Gene symbol
    tax
    Gene description
    p40
    Locus tag
    HTLV1gp7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human T-lymphotropic virus 1 (old-name: Human T-cell lymphotropic virus type 1)
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Deltaretrovirus
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    Genomic context

    Sequence :
    NC_001436.1 (4829..8008)

    NC_001436.1Genomic Context describing neighboring genes Neighboring gene Pr gag-pro Neighboring gene Pr gag-pro-pol Neighboring gene Pr55 Neighboring gene Neighboring gene Neighboring gene p27 Neighboring gene protein-coding

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation. Lavorgna A, et al. J Virol, 2012 Mar. PMID 22258247.
    2. Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators. Toufaily C, et al. Viruses, 2011 Nov. PMID 22163338.
    3. The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax. Fryrear KA, et al. Blood, 2012 Feb 2. PMID 22106342.
    4. Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth. Yoshita M, et al. Cancer Sci, 2012 Feb. PMID 22010857.
    5. Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax. Polakowski N, et al. Viruses, 2011 Aug. PMID 21994792.

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Tax-induced miR-146a expression in a NF-kappaB-dependent manner and inhibited the expression of gene harboring the target sequence of miR-146a on its 3'UTR.
      Title: MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells.
    2. Cellular STAMBPL1 is a positive regulator of human T-cell leukemia virus type 1 Tax-mediated NF-kappaB signaling.
      Title: An RNA interference screen identifies the Deubiquitinase STAMBPL1 as a critical regulator of human T-cell leukemia virus type 1 tax nuclear export and NF-κB activation.
    3. RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.
      Title: The Sumo-targeted ubiquitin ligase RNF4 regulates the localization and function of the HTLV-1 oncoprotein Tax.
    4. HTLV-1 Tax activates several human endogenous retrovirus LTRs.
      Title: Activation of LTRs from different human endogenous retrovirus (HERV) families by the HTLV-1 tax protein and T-cell activators.
    5. results suggest that Tax activates the mTOR pathway in T cells, and that this activation plays a crucial role in the growth of HTLV
      Title: Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth.
    6. Tax represses expression of RNase T2.
      Title: Direct inhibition of RNAse T2 expression by the HTLV-1 viral protein Tax.
    7. Posttranslational modifications of Tax control its intracellular localization, transactivation and transforming activities.[review]
      Title: Move or die: the fate of the Tax oncoprotein of HTLV-1.
    8. Tax proteins of HTLV-1 and HTLV-2 are different in cellular localization and cellular factors interaction.
      Title: Intracellular localization and cellular factors interaction of HTLV-1 and HTLV-2 Tax proteins: similarities and functional differences.
    9. Human T-cell lymphotropic virus type 1 Tax-1 and CIITA physically interact in vivo via the first 108 amino acids of Tax-1 and two CIITA adjacent regions (amino acids 1 to 252 and 253 to 410).
      Title: Major histocompatibility complex class II transactivator CIITA is a viral restriction factor that targets human T-cell lymphotropic virus type 1 Tax-1 function and inhibits viral replication.
    10. Data indicate that p13 protein directly binds Tax, decreases Tax binding to the CBP/p300 transcriptional coactivator, and, by reducing Tax transcriptional activity, suppresses viral expression.
      Title: Suppression of HTLV-1 replication by Tax-mediated rerouting of the p13 viral protein to nuclear speckles.
    Submit: New GeneRIF Correction See all (101)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_057864.1 NP_001604.1 ACTA2    BIND  PubMed Tax interacts with Actin. 
    NP_057864.1 ANXA6    BIND  PubMed Tax interacts with Annexin VI. 
    NP_057864.1 CDC42    BIND  PubMed Tax interacts with Cdc42. 
    NP_057864.1 NP_148978.1 CDK16    BIND  PubMed Tax interacts with PCTAIRE-1. 
    NP_057864.1 CDK2    BIND  PubMed Tax interacts with an unspecified isoform of Cdk2. 
    NP_057864.1 NP_000066.1 CDK4    BIND  PubMed Tax interacts with CDK4. 
    NP_057864.1 NP_001250.1 CDK6    BIND  PubMed Tax interacts with CDK6. 
    NP_057864.1 NP_004078.1 DLG1    BIND  PubMed Human DLG1 (DLG) interacts with Human T cell leukemia virus type-1 Tax. 
    NP_057864.1 NP_001559.1 EIF3E    BIND  PubMed Tax interacts with Int6. 
    NP_057864.1 NP_000168.1 GSN    BIND  PubMed Tax interacts with Gelsolin. 
    NP_057864.1 NP_003630.1 IKBKG    BIND  PubMed Tax interacts with IKK-gamma. 
    NP_057864.1 NP_003541.1 MAD1L1    BIND  PubMed TXBP181 interacts with Tax. 
    NP_057864.1 NP_003918.1 MBD2    BIND  PubMed Tax interacts with MBD2. 
    NP_057864.1 AF033817.1 NEWENTRY    BIND  PubMed Tax interacts with HTLV-1 5' LTR chromatin. 
    NP_057864.1 NP_002569.1 PAK3    BIND  PubMed Tax interacts with PAK3. 
    NP_057864.1 RAC1    BIND  PubMed Tax interacts with Rac1. 
    NP_057864.1 RAD51    BIND  PubMed Tax interacts with an unspecified isoform of Rad51. 
    NP_057864.1 NP_000527.1 RAG2    BIND  PubMed Tax interacts with RAG2. 
    NP_057864.1 NP_006497.2 RASA2    BIND  PubMed Tax interacts with GAP1m. 
    NP_057864.1 NP_001655.1 RHOA    BIND  PubMed Tax interacts with RhoA. 
    NP_057864.1 NP_003063.2 SMARCA4    BIND  PubMed Tax interacts with BRG1. 
    NP_057864.1 NP_003065.2 SMARCC1    BIND  PubMed Tax interacts with BAF155. 
    NP_057864.1 NP_003070.3 SMARCE1    BIND  PubMed Tax interacts with BAF57. 
    NP_057864.1 NP_612482.2 SP1    BIND  PubMed Tax interacts with Sp1. 
    NP_057864.1 NP_003398.1 ZFP36    BIND  PubMed Tax-1 interacts with TTP. 
    NP_057864.1 NP_057864.1 tax    BIND  PubMed Tax interacts with itself. 
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    General protein information

    Names
    p40
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    mRNA and Protein(s)

    1. NP_057864.1 p40 [Human T-lymphotropic virus 1]

      UniProtKB/Swiss-Prot
      P14079
      Conserved Domains (1) summary
      pfam02959
      Location:3 – 224
      Blast Score: 730
      Tax; HTLV Tax
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF033817.1 AAC82583.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O56231.1 GenPept
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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