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Gucy2c guanylate cyclase 2c [ Mus musculus (house mouse) ]

Gene ID: 14917, updated on 8-May-2016
Official Symbol
Gucy2cprovided by MGI
Official Full Name
guanylate cyclase 2cprovided by MGI
Primary source
MGI:MGI:106903
See related
Ensembl:ENSMUSG00000042638 Vega:OTTMUSG00000033823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcc; GC-C; AI893437
Orthologs
Location:
6 G1; 6 66.67 cM
Exon count:
27
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (136697284..136781742, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (136645805..136730263, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene phospholipase B domain containing 1 Neighboring gene predicted gene, 40409 Neighboring gene protein S100-A10 pseudogene Neighboring gene predicted gene, 40410 Neighboring gene predicted gene, 40411 Neighboring gene histone cluster 4, H4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC107510

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
guanylate cyclase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphorus-oxygen lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cGMP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
cGMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
heat-stable enterotoxin receptor
Names
STA receptor
guanylyl cyclase C
heat stable enterotoxin receptor
intestinal guanylate cyclase
NP_001120790.1
NP_659504.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127318.1NP_001120790.1  heat-stable enterotoxin receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001120790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1).
    Source sequence(s)
    AK136496, CF353627
    Consensus CDS
    CCDS51941.1
    UniProtKB/Swiss-Prot
    Q3UWA6
    Related
    ENSMUSP00000032338, OTTMUSP00000046000, ENSMUST00000032338, OTTMUST00000085207
    Conserved Domains (6) summary
    cd07302
    Location:821999
    CHD; cyclase homology domain
    smart00044
    Location:787978
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam01094
    Location:54374
    ANF_receptor; Receptor family ligand binding region
    pfam07714
    Location:502744
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:480749
    PKc_like; Protein Kinases, catalytic domain
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  2. NM_145067.3NP_659504.2  heat-stable enterotoxin receptor isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK136496, CF353627
    Consensus CDS
    CCDS20653.1
    UniProtKB/Swiss-Prot
    Q3UWA6
    Related
    ENSMUSP00000077236, OTTMUSP00000046002, ENSMUST00000078095, OTTMUST00000085209
    Conserved Domains (5) summary
    cd07302
    Location:797975
    CHD; cyclase homology domain
    smart00044
    Location:763954
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam01094
    Location:54374
    ANF_receptor; Receptor family ligand binding region
    cl21453
    Location:480725
    PKc_like; Protein Kinases, catalytic domain
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    136697284..136781742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    139693560..139778559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)