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    SV40gp7 small t antigen [ Simian virus 40 ]

    Gene ID: 1489525, updated on 3-Apr-2013
    Gene symbol
    SV40gp7
    Gene description
    small t antigen
    Locus tag
    SV40gp7
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Simian virus 40 (old-name: Polyomavirus maccacae)
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Polyomaviridae; Polyomavirus
    Sequence :
    NC_001669.1 (4639..5163, complement)

    NC_001669.1Genomic Context describing neighboring genes Neighboring gene VP2 minor structural protein Neighboring gene VP3 minor structural protein Neighboring gene VP1 major structural protein Neighboring gene large T antigen Neighboring gene miscRNA Neighboring gene early leader protein (SELP; [133])

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. Andrabi S, et al. J Virol, 2011 Oct. PMID 21835797.
    2. Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. Kumar SH, et al. J Virol, 2009 Sep. PMID 19515765.
    3. Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E. Sotillo E, et al. J Biol Chem, 2009 May 22. PMID 19321444.
    4. Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. Sotillo E, et al. J Biol Chem, 2008 Apr 25. PMID 18276582.
    5. Structural basis of PP2A inhibition by small t antigen. Cho US, et al. PLoS Biol, 2007 Aug. PMID 17608567.

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors show that there are major differences between SV40 small T antigen and murine polyomavirus small T antigen in their effects on differentiation, transformation, and cell survival.
      Title: Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.
    2. The authors show that SV40 ST antigen in cancers, where it functions to maintain energy homeostasis during glucose deprivation by activating AMP-activated protein kinase, inhibiting mTOR, and inducing autophagy as an alternate energy source.
      Title: Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation.
    3. The combination of st and deregulated cyclin E result in cooperative and coordinated activation of both an essential origin licensing factor, CDC6, and an activity required for origin firing, CDK2, resulting in progression from quiescence to S phase.
      Title: Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.
    4. Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts
      Title: Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts.
    5. Results describe the crystal structure of full-length SV40 small t antigen in complex with protein phosphatase 2A A subunit at 3.1 A resolution.
      Title: Structural basis of PP2A inhibition by small t antigen.
    Submit: New GeneRIF Correction
    Preferred Names
    small t antigen
    Names
    Small T antigen
    YP_003708383.1
    • small T-antigen; promotes the efficient replication of genomic DNA; binds to and negativley regulates the function of protein phosphotase (PP2A) thereby accelerating the progression to S-phase; the small T-antigen shares a region in common with the large T-antigen known as the J-domain; the J-domain is required for multiple processes including assembly, viral genomic DNA replication and transcription; The polyomaviruses are non-enveloped dsDNA viruses; the viral genome is organized into two divergent transcriptional units known as early and late regions; mRNAs from the early region encode the viral small and large t-antigens; the small T antigen and large T antigen are expressed upon entry into the host nucleus early in the viral lifecycle; the small T antigen is not essential for replication in all cell lines

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001669.1

      Range
      4639..5163, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_003708383.1 Small T antigen [Simian virus 40]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03081
      UniProtKB/TrEMBL
      Q77JR6
      Conserved Domains (3) summary
      cd06257
      Location:15 – 60
      Blast Score: 99
      DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
      pfam02380
      Location:83 – 174
      Blast Score: 344
      Papo_T_antigen; T-antigen specific domain
      PHA03102
      Location:7 – 153
      Blast Score: 527
      PHA03102; Small T antigen; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    genomic J02400.1 AAB59925.1
    genomic EF579667.1 ABU86098.1
    genomic EF579663.1 ABU86074.1
    genomic AF316139.1 AAG39203.1
    genomic AF316141.1 AAG39215.1
    genomic EF579804.1 ABU62651.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P03081.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content

      Table of contents

      Related information

      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • Protein Clusters
        Related Protein Clusters
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      General information

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