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MOB3C MOB kinase activator 3C [ Homo sapiens (human) ]

Gene ID: 148932, updated on 26-May-2016
Official Symbol
MOB3Cprovided by HGNC
Official Full Name
MOB kinase activator 3Cprovided by HGNC
Primary source
HGNC:HGNC:29800
See related
Ensembl:ENSG00000142961 HPRD:17584; Vega:OTTHUMG00000007989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOB1E; MOBKL2C
Summary
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p33
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (46607715..46616891, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47073387..47082563, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MKNK1 antisense RNA 1 Neighboring gene kinocilin Neighboring gene MAP kinase interacting serine/threonine kinase 1 Neighboring gene uncharacterized LOC105378697 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC26743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Preferred Names
MOB kinase activator 3C
Names
MOB1, Mps One Binder kinase activator-like 2C
mob1 homolog 2C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027514.1 RefSeqGene

    Range
    5001..14177
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_145279.4NP_660322.2  MOB kinase activator 3C isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant encodes the longer isoform (1).
    Source sequence(s)
    AL136373
    Consensus CDS
    CCDS539.1
    UniProtKB/TrEMBL
    X6R3L3
    Related
    ENSP00000271139, OTTHUMP00000009682, ENST00000271139, OTTHUMT00000021925
    Conserved Domains (1) summary
    pfam03637
    Location:87260
    Mob1_phocein; Mob1/phocein family
  2. NM_201403.2NP_958805.1  MOB kinase activator 3C isoform 2

    See identical proteins and their annotated locations for NP_958805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant uses an alternate 5' UTR exon, compared to variant 1, that results in the use of a downstream start codon. The encoded isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL136373
    Consensus CDS
    CCDS540.1
    UniProtKB/Swiss-Prot
    Q70IA8
    Related
    ENSP00000315113, ENST00000319928
    Conserved Domains (1) summary
    pfam03637
    Location:35208
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    46607715..46616891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    47190398..47199558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)