Sign in to NCBI

Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

    E6 transforming protein [ Human papillomavirus type 16 ]

    Gene ID: 1489078, updated on 4-May-2013
    Gene symbol
    E6
    Gene description
    transforming protein
    Locus tag
    HpV16gp1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human papillomavirus type 16
    Lineage
    Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Alphapapillomavirus
    Sequence :
    NC_001526.2 (83..559)

    NC_001526.2Genomic Context describing neighboring genes Neighboring gene transforming protein Neighboring gene E1 Neighboring gene regulatory protein

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer. Wang S, et al. FEBS Lett, 2013 Mar 18. PMID 23410891.
    2. Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Zanier K, et al. Science, 2013 Feb 8. PMID 23393263.
    3. High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. Boon SS, et al. J Virol, 2013 Feb. PMID 23175360.
    4. Biomarkers of HPV in head and neck squamous cell carcinoma. Liang C, et al. Cancer Res, 2012 Oct 1. PMID 22991304.
    5. The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes. Niccoli S, et al. J Virol, 2012 Nov. PMID 22951839.

    See all (123) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
      Title: HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer.
    2. study observed that transiently expressed GFP-16E6 was located in the nuclei together with the endogenous wt p53 protein, which in turn induced apoptosis
      Title: GFP/HPV-16E6 fusion protein induces apoptosis in MCF-7 and 293T cells using a transient expression system.
    3. The interaction is direct and specific for the high-risk HPV E6 oncoproteins, although there are significant differences in the efficiencies with which HPV-16, HPV-18, and HPV-31 E6 oncoproteins can associate with 14-3-3zeta.
      Title: High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner.
    4. crystal structure of HPV16 E6 protein bound to LxxLL peptides from the ubiquitin ligase E6AP; work reveals the structural basis of both the multifunctionality and the oncogenicity of E6 proteins
      Title: Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.
    5. Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes
      Title: The Asian-American E6 variant protein of human papillomavirus 16 alone is sufficient to promote immortalization, transformation, and migration of primary human foreskin keratinocytes.
    6. Data suggest that the combination of HPV16-positive DNA and E6 or E7 serology was associated with enhanced overall survival in oropharyngeal disease.
      Title: Biomarkers of HPV in head and neck squamous cell carcinoma.
    7. solution structure analysis of the HPV16 E6; homodimer interface mutations that disrupt E6 self-association also inactivate E6-mediated p53 degradation; data suggest that E6 needs to self-associate via its N-terminal domain to promote the polyubiquitination of p53 by E6AP
      Title: Solution structure analysis of the HPV16 E6 oncoprotein reveals a self-association mechanism required for E6-mediated degradation of p53.
    8. Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40
      Title: Human papillomavirus type 16 E6 protein inhibits DNA fragmentation via interaction with DNA fragmentation factor 40.
    9. presence of HPV16 E6 variants in tonsillar squamous cell carcinoma (TSCC) in cervical cancer (CC), as well as in cervical samples
      Title: Human papillomavirus (HPV) 16 E6 variants in tonsillar cancer in comparison to those in cervical cancer in Stockholm, Sweden.
    10. A reduced responsiveness to cell-cell contact inhibition and an increase in E6/E7 activity correlated closely with phenotype.
      Title: Reconstruction of human papillomavirus type 16-mediated early-stage neoplasia implicates E6/E7 deregulation and the loss of contact inhibition in neoplastic progression.
    Submit: New GeneRIF Correction See all (120)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_041325.1 NP_002189.1 IRF1    BIND  PubMed Human papillomavirus type 16 (HPV16) protein E6 interacts with human host protein IRF-1. 
    NP_041325.1 NP_001562.1 IRF3    BIND  PubMed Human papillomavirus type 16 (HPV16) protein E6 interacts with human host protein IRF-3. 
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
      Extrinsic Pathway for Apoptosis, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
      FasL/ CD95L signaling, organism-specific biosystemThe Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the t...
    • Regulation of Telomerase, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Telomerase, organism-specific biosystem
      Regulation of Telomerase
    • TNF signaling, organism-specific biosystem (from REACTOME)
      TNF signaling, organism-specific biosystemThe Tumor Necrosis Factor alpha (TNF-alpha) mediated apoptosis pathway has been implicated in the pathogenesis of a number of diseases including sepsis, diabetes, cancer, osteoporosis, multiple scler...
    • TRAIL signaling, organism-specific biosystem (from REACTOME)
      TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
    Names
    transforming protein
    NP_041325.1
    • E6 ORF from 65 to 559; putative

    VOG classification

    Description:

    • VOGd0194 [R] Early oncoprotein E6
    • Regulation of Cellular Metabolism

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001526.2

      Range
      83..559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_041325.1 transforming protein [Human papillomavirus type 16]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03126
      UniProtKB/TrEMBL
      Q547J2
      Conserved Domains (1) summary
      pfam00518
      Location:37 – 141
      Blast Score: 388
      E6; Early Protein (E6)
    Nucleotide Protein
    Heading Accession and Version
    genomic EU880251.1 ACK57860.1
    genomic EU880250.1 ACK57859.1
    genomic EU880249.1 ACK57858.1
    genomic EU880260.1 ACK57867.1
    genomic JN381047.1 AEV66127.1
    genomic EU880252.1 ACK57861.1
    genomic EU880254.1 ACK57862.1
    genomic EU880262.1 ACK57868.1
    genomic EU880257.1 ACK57864.1
    genomic HM211089.1 ADY75575.1
    genomic JN381057.1 AEV66137.1
    genomic EU880248.1 ACK57857.1
    genomic EU880258.1 ACK57865.1
    genomic JN381061.1 AEV66141.1
    genomic EU880259.1 ACK57866.1
    genomic FJ610149.1 ACS92668.1
    genomic EF422095.1 ABR08416.1
    genomic K02718.1 AAA46939.1
    genomic AY098919.1 AAM29167.1
    genomic FJ610146.1 ACS92644.1
    genomic AY686584.1 AAV91684.1
    genomic AY686581.1 AAV91660.1
    genomic AF486310.1 AAL96615.1
    genomic AF486311.1 AAL96616.1
    genomic AF486312.1 AAL96617.1
    genomic AF486321.1 AAL96626.1
    genomic AF486320.1 AAL96625.1
    genomic AF486317.1 AAL96622.1
    genomic AF486313.1 AAL96618.1
    genomic EU880247.1 ACK57856.1
    genomic EF422108.1 ABR08429.1
    genomic EF422107.1 ABR08428.1
    genomic EU880263.1 ACK57869.1
    genomic FJ610150.1 ACS92676.1
    genomic EU880265.1 ACK57871.1
    genomic EU880266.1 ACK57872.1
    genomic EU880267.1 ACK57873.1
    genomic EU880268.1 ACK57874.1
    genomic EF422106.1 ABR08427.1
    genomic EU880269.1 ACK57875.1
    genomic JX412120.1 AFS64234.1
    genomic EF422104.1 ABR08425.1
    genomic EU880270.1 ACK57876.1
    genomic EU880271.1 ACK57877.1
    genomic EF422098.1 ABR08419.1
    genomic EF422097.1 ABR08418.1
    genomic EU880272.1 ACK57878.1
    genomic EF422096.1 ABR08417.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q547J2.1 GenPept

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • 3D structures
        3D structure of a gene
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...