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Gtf2h4 general transcription factor II H, polypeptide 4 [ Mus musculus (house mouse) ]

Gene ID: 14885, updated on 8-May-2016
Official Symbol
Gtf2h4provided by MGI
Official Full Name
general transcription factor II H, polypeptide 4provided by MGI
Primary source
MGI:MGI:1338799
See related
Ensembl:ENSMUSG00000001524 Vega:OTTMUSG00000034602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p52; AW545633; BTF2 p52
Summary
This gene encodes a subunit of the general transcription factor multiprotein complex that plays roles in basal transcription, DNA repair and cell cycle control. [provided by RefSeq, Dec 2014]
Orthologs
Location:
17; 17 B1
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (35667728..35673750, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (35804684..35810627, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene surfactant associated 2 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene discoidin domain receptor family, member 1 Neighboring gene uncharacterized LOC105246271 Neighboring gene RIKEN cDNA 4833427F10 gene Neighboring gene predicted gene, 32409

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP-dependent DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-dependent ATPase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II carboxy-terminal domain kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to RNA polymerase II carboxy-terminal domain kinase activity ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphorylation of RNA polymerase II C-terminal domain IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
core TFIIH complex IBA
Inferred from Biological aspect of Ancestor
more info
 
holo TFIIH complex IBA
Inferred from Biological aspect of Ancestor
more info
 
holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
general transcription factor IIH subunit 4
Names
TFIIH basal transcription factor complex p52 subunit
basic transcription factor 2 52 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010364.4NP_034494.1  general transcription factor IIH subunit 4

    See identical proteins and their annotated locations for NP_034494.1

    Status: REVIEWED

    Source sequence(s)
    AK144680, BY109905, CR974483
    Consensus CDS
    CCDS28702.1
    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3
    Related
    ENSMUSP00000001565, OTTMUSP00000047801, ENSMUST00000001565, OTTMUST00000087787
    Conserved Domains (1) summary
    TIGR00625
    Location:19461
    tfb2; Transcription factor tfb2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    35667728..35673750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523669.2XP_006523732.1  

    See identical proteins and their annotated locations for XP_006523732.1

    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3
    Related
    ENSMUSP00000124335, OTTMUSP00000047803, ENSMUST00000160734, OTTMUST00000087789
    Conserved Domains (1) summary
    TIGR00625
    Location:19461
    tfb2; Transcription factor tfb2
  2. XM_006523668.2XP_006523731.1  

    See identical proteins and their annotated locations for XP_006523731.1

    UniProtKB/Swiss-Prot
    O70422
    UniProtKB/TrEMBL
    Q542U3
    Conserved Domains (1) summary
    TIGR00625
    Location:19461
    tfb2; Transcription factor tfb2

Reference GRCm38.p3 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p3 NOD/MrkTac

    Range
    1978103..1984124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p3 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p3 NOD/ShiLtJ

    Range
    2001699..2007720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    39186269..39188757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)