These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_001083914.1 → NP_001077383.1 C-terminal-binding protein 2 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) contains a distinct 5' UTR and 5' CDS, compared to variant 2. Both variants 1 and 3 encode the same isoform (1), which has a distinct N-terminus that is 540 aa shorter than the N-terminus of isoform 2. The protein is thought to bind to the C-terminus of the adenovirus E1A proteins. Studies in mice suggest that this protein is involved in transcriptional repression.
- Source sequence(s)
-
AL731571, BC047018, CN353451
- Consensus CDS
-
CCDS7643.1
- UniProtKB/Swiss-Prot
-
P56545
- Related
- ENSP00000410474, OTTHUMP00000235910, ENST00000411419, OTTHUMT00000394563
- Conserved Domains (2) summary
-
- pfam00389
Location:38 – 358
Blast Score: 541
- 2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- cl09931
Location:139 – 323
Blast Score: 469
- NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
-
NM_001329.2 → NP_001320.1 C-terminal-binding protein 2 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) contains a distinct 5' UTR and 5' CDS, compared to variant 2. Both variants 1 and 3 encode the same isoform (1), which has a distinct N-terminus that is 540 aa shorter than the N-terminus of isoform 2. The protein is thought to bind to the C-terminus of the adenovirus E1A proteins. Studies in mice suggest that this protein is involved in transcriptional repression.
- Source sequence(s)
-
AL731571, AL833398, BQ933925
- Consensus CDS
-
CCDS7643.1
- UniProtKB/Swiss-Prot
-
P56545
- Related
- ENSP00000338615, OTTHUMP00000020699, ENST00000337195, OTTHUMT00000050900
- Conserved Domains (2) summary
-
- pfam00389
Location:38 – 358
Blast Score: 541
- 2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- cl09931
Location:139 – 323
Blast Score: 469
- NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
-
NM_022802.2 → NP_073713.2 C-terminal-binding protein 2 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (2). This protein localizes to synaptic ribbons, synapses used for fast tonic neurotransmitter release in a subset of specialized neurons.
- Source sequence(s)
-
AF222711, AL731571, AL833398
- Consensus CDS
-
CCDS7644.1
- UniProtKB/Swiss-Prot
-
P56545
- Related
- ENSP00000311825, OTTHUMP00000020701, ENST00000309035, OTTHUMT00000050905
- Conserved Domains (3) summary
-
- PHA03247
Location:384 – 595
Blast Score: 90
- PHA03247; large tegument protein UL36; Provisional
- pfam00389
Location:578 – 898
Blast Score: 575
- 2-Hacid_dh; D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
- cl09931
Location:679 – 863
Blast Score: 478
- NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000010.10 Reference GRCh37.p5 Primary Assembly
- Range
- 126676418..126849624, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000142.1 Alternate HuRef
- Range
- 120363415..120536674, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)