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    UBE2U ubiquitin-conjugating enzyme E2U (putative) [ Homo sapiens ]

    Gene ID: 148581, updated on 11-May-2012

    Summary

    Official Symbol
    UBE2Uprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2U (putative)provided by HGNC
    Primary source
    HGNC:28559
    See related
    Ensembl:ENSG00000177414; HPRD:14599; Vega:OTTHUMG00000009023
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP4-636O23.1; MGC35130

    Genomic context

    Location :
    1p31.3
    Sequence :
    Chromosome: 1; NC_000001.10 (64669490..64710027)
    See UBE2U in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 3 Neighboring gene receptor tyrosine kinase-like orphan receptor 1 Neighboring gene cofilin 1 (non-muscle) pseudogene 3 Neighboring gene cache domain containing 1 Neighboring gene microRNA 4794 Neighboring gene ribonucleoprotein, PTB-binding 2 Neighboring gene Janus kinase 1

    Genomic regions, transcripts, and products

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:127156 BioGRID:119591 ANAPC11    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:107056 BARD1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:119435 BFAR    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:125051 CADPS2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115910 CGRRF1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:108173 DTX1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115021 DZIP3    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:113703 KAT6A    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:110358 MDM2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:121593 MIB1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:126769 MIB2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:116231 MID2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:113479 MKRN3    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:122734 MUL1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124243 PCGF1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:113497 PCGF2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:123896 PCGF6    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:122109 PJA1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:111384 PML    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115862 RBCK1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115249 RNF10    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:117941 RNF11    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:113523 RNF113A    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:126603 RNF113B    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:120991 RNF114    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:120281 RNF125    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:116401 RNF139    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:114968 RNF14    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:129106 RNF144B    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:121553 RNF150    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:125465 RNF166    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:121096 RNF17    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:123583 RNF170    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:119411 RNF181    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:111972 RNF2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:122133 RNF25    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:122549 RNF26    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115488 RNF41    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:111975 RNF5    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:119323 RNFT1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124085 SYVN1    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115581 TRAIP    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124626 TRIM15    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:116910 TRIM2    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:106868 TRIM23    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:114333 TRIM24    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115457 TRIM28    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115858 TRIM3    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:116608 TRIM32    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:119809 TRIM34    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:116716 TRIM35    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:110678 TRIM37    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:115738 TRIM38    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:123129 TRIM46    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124794 TRIM47    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124491 TRIM5    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:121415 TRIM54    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:124195 TRIM63    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:128382 TRIM65    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:120434 TRIM68    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:132031 TRIM74    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:120930 VPS11    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:117982 VPS41    BioGRID  PubMed Two-hybrid 
    BioGRID:127156 BioGRID:127342 ZSWIM2    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 U
    Names
    ubiquitin-conjugating enzyme E2 U
    ubiquitin-protein ligase U
    ubiquitin carrier protein U
    NP_689702.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152489.1NP_689702.1  ubiquitin-conjugating enzyme E2 U

      Status: PROVISIONAL

      Source sequence(s)
      BC029895
      Consensus CDS
      CCDS627.1
      UniProtKB/Swiss-Prot
      Q5VVX9
      Related
      ENSP00000360116, OTTHUMP00000010575, ENST00000371076, OTTHUMT00000025005
      Conserved Domains (1) summary
      cd00195
      Location:8147
      Blast Score: 336
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      64669490..64710027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      62778392..62818851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL161916.8 CAI22119.1
      CAI22120.1
    genomic AL445205.14 CAH71707.1
      CAH71708.1
    genomic CH471059.2 EAX06552.1
      EAX06553.1
      EAX06554.1
    mRNA BC029895.1 AAH29895.1
    other-genetic DQ891312.2 ABM82238.1
    other-genetic DQ894496.2 ABM85422.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VVX9.1 GenPept UniProtKB/Swiss-Prot:Q5VVX9

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