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    CTAG1B cancer/testis antigen 1B [ Homo sapiens ]

    Gene ID: 1485, updated on 11-May-2012
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    Summary

    Official Symbol
    CTAG1Bprovided by HGNC
    Official Full Name
    cancer/testis antigen 1Bprovided by HGNC
    Primary source
    HGNC:2491
    See related
    Ensembl:ENSG00000184033; HPRD:02151; MIM:300156; Vega:OTTHUMG00000024232
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTAG; ESO1; CT6.1; CTAG1; CTAG1A; LAGE-2; LAGE2B; NY-ESO-1
    Summary
    The protein encoded by this gene is an antigen that is overexpressed in many cancers but that is also expressed in normal testis. This gene is found in a duplicated region of the X-chromosome and therefore has a neighboring gene of identical sequence. [provided by RefSeq, Jan 2012]
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    Genomic context

    Location :
    Xq28
    Sequence :
    Chromosome: X; NC_000023.10 (153845865..153847522, complement)
    See CTAG1B in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene activating transcription factor 4 pseudogene 2 Neighboring gene cancer/testis antigen 1A Neighboring gene activating transcription factor 4 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 204B

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab. Yuan J, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933959.
    2. Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo. Liu Y, et al. J Biol Chem, 2011 Oct 28. PMID 21900253.
    3. MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma. Bujas T, et al. Eur J Histochem, 2011 Mar 21. PMID 21556122.
    4. Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy. de Carvalho F, et al. Cancer Immun, 2011 Jan 20. PMID 21247062.
    5. Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1. Kudela P, et al. J Immunol, 2011 Jan 1. PMID 21131422.

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Polymeric structure and TLR4 may play important roles in rendering NY-ESO-1 immunogenic and thus serve as a potent molecular adjuvant. NY-ESO-1 thus represents the first example of a cancer/testis antigen
      Title: Polymeric structure and host Toll-like receptor 4 dictate immunogenicity of NY-ESO-1 antigen in vivo.
    2. Integrated NY-ESO-1 immune responses may have predictive value for ipilimumab treatment in patients with advanced metastatic melanoma.
      Title: Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.
    3. Primary tumors with and without lymph node metastases showed no significant differences in MAGE-A 3/4 (P=0.672) and NY-ESO-1 (P=0.444) expression
      Title: MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma.
    4. LAGE-1a and NY-ESO-1 homology cannot be easily exploited in an anti-NY-ESO-1 vaccine given the low frequency of protein expression detected by IHC or serum analysis.
      Title: Evaluation of LAGE-1 and NY-ESO-1 expression in multiple myeloma patients to explore possible benefits of their homology for immunotherapy.
    5. Report immunohistochemical expression of NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma.
      Title: Immunohistochemical expression of tumor antigens MAGE-A3/4 and NY-ESO-1 in renal oncocytoma and chromophobe renal cell carcinoma.
    6. Most melanoma patients with spontaneous NY-ESO-1-specific responses in this study exhibit spontaneous CD4-positive T cell responses to at least one of the three immunodominant LAGE-1 epitopes.
      Title: Epitope hierarchy of spontaneous CD4+ T cell responses to LAGE-1.
    7. A versatile prime-boost vaccine strategy allows the generation of powerful, high-avidity tumor-associated immunodominant NY-ESO-1-transgene specific CD8-positive cytotoxic T cell responses.
      Title: Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice.
    8. tumor antigen NY-ESO-1 has a role in the immune responses to tumor and self-antigens
      Title: Monitoring of NY-ESO-1 specific CD4+ T cells using molecularly defined MHC class II/His-tag-peptide tetramers.
    9. ESO 9V peptide isoform is more efficient in inducing conjugate formation and cytolytic granule polarization than the ESO 9L isoform.
      Title: Ca2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.
    10. MAGE-A3/6 and NY-ESO-1 were expressed in 50.0% (66/132) and 18.2% (24/132) of non-small-cell lung carcinomas, respectively.
      Title: Expression of cancer-testis antigens MAGE-A3/6 and NY-ESO-1 in non-small-cell lung carcinomas and their relationship with immune cell infiltration.
    Submit: New GeneRIF Correction See all (47)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P78358 P01912 HLA-DRB1    HPRD  PubMed  
    P78358 P20039 HLA-DRB1    HPRD  PubMed  
    P78358 P01913 HLA-DRB3    HPRD  PubMed  
    P78358 P13762 HLA-DRB4    HPRD  PubMed  
    P78358 O60732 MAGEC1    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

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    General protein information

    Preferred Names
    cancer/testis antigen 1
    Names
    cancer/testis antigen 1
    cancer antigen 3
    cancer/testis antigen 6.1
    l antigen family member 2
    New York esophageal squamous cell carcinoma 1
    autoimmunogenic cancer/testis antigen NY-ESO-1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001327.2 → NP_001318.1  cancer/testis antigen 1

      Status: REVIEWED

      Source sequence(s)
      U87459
      Consensus CDS
      CCDS14758.1
      UniProtKB/Swiss-Prot
      P78358
      Related
      ENSP00000332602, OTTHUMP00000026025, ENST00000328435, OTTHUMT00000061151
      Conserved Domains (1) summary
      cl12080
      Location:92 – 143
      Blast Score: 137
      Pcc1; Transcription factor Pcc1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      153845865..153847522, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      142391018..142392145, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF277315.6 AAL27014.1
    genomic AJ275977.1 CAB76943.1
      CAB76944.1
    genomic AJ275977.1 CAB76943.1
      CAB76944.1
    genomic CH471172.2 EAW72674.1
    mRNA AF038567.1 AAD05202.1
      AAD05203.1
    mRNA AJ003149.1 CAA05908.1
    mRNA AJ275978.1 CAB76945.1
    mRNA BC130362.1 AAI30363.1
    mRNA BC130364.1 AAI30365.1
    mRNA U87459.1 AAB49693.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95146 GenPept UniProtKB/TrEMBL:O95146
    P78358.1 GenPept UniProtKB/Swiss-Prot:P78358
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Miscellaneous

      Supplemental Content

      Table of contents

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