Format

Send to:

Choose Destination

CDC42EP5 CDC42 effector protein 5 [ Homo sapiens (human) ]

Gene ID: 148170, updated on 12-May-2016
Official Symbol
CDC42EP5provided by HGNC
Official Full Name
CDC42 effector protein 5provided by HGNC
Primary source
HGNC:HGNC:17408
See related
Ensembl:ENSG00000167617 HPRD:13023; MIM:609171; Vega:OTTHUMG00000065699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP5; Borg3
Summary
Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]
Orthologs
Location:
19q13.42
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 19 NC_000019.10 (54465025..54473290, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54976210..54984422, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene LENG8 antisense RNA 1 Neighboring gene leukocyte receptor cluster (LRC) member 8 Neighboring gene leukocyte receptor cluster (LRC) member 9 Neighboring gene leukocyte associated immunoglobulin like receptor 2 Neighboring gene killer cell immunoglobulin-like receptor 3DL1

  • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
    MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
  • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
    MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC21945, MGC71153

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding IPI
Inferred from Physical Interaction
more info
PubMed 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
JNK cascade IEA
Inferred from Electronic Annotation
more info
 
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pseudopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
cdc42 effector protein 5
Names
CDC42 effector protein (Rho GTPase binding) 5
binder of Rho GTPases 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145057.3NP_659494.2  cdc42 effector protein 5

    See identical proteins and their annotated locations for NP_659494.2

    Status: REVIEWED

    Source sequence(s)
    AI379873, BC024327, BC065910, DA867588
    Consensus CDS
    CCDS12896.1
    UniProtKB/Swiss-Prot
    Q6NZY7
    Related
    ENSP00000301200, OTTHUMP00000068391, ENST00000301200, OTTHUMT00000140804
    Conserved Domains (2) summary
    pfam00786
    Location:2349
    PBD; P21-Rho-binding domain
    pfam14957
    Location:83108
    BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p2 Primary Assembly

    Range
    54465025..54473290 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NW_003571054.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    371538..379704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NW_003571060.1 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    369717..377945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_9

Genomic

  1. NT_187693.1 Reference GRCh38.p2 ALT_REF_LOCI_9

    Range
    447323..455551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 Alternate CHM1_1.1

    Range
    54970044..54978309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)