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Grik1 glutamate receptor, ionotropic, kainate 1 [ Mus musculus (house mouse) ]

Gene ID: 14805, updated on 24-May-2016
Official Symbol
Grik1provided by MGI
Official Full Name
glutamate receptor, ionotropic, kainate 1provided by MGI
Primary source
MGI:MGI:95814
See related
Ensembl:ENSMUSG00000022935
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluK1; GluK5; Glur5; Glur-5; D16Ium24; D16Ium24e; Glurbeta1; A830007B11Rik
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16 C3.3; 16 50.23 cM
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (87895897..88290602, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (87896142..88290503, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32925 Neighboring gene RIKEN cDNA 2810407A14 gene Neighboring gene uncharacterized LOC105246151 Neighboring gene predicted gene, 33207 Neighboring gene predicted gene, 41486 Neighboring gene predicted gene, 33255 Neighboring gene claudin 17

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC25101

Gene Ontology Provided by MGI

Function Evidence Code Pubs
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellular-glutamate-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
kainate selective glutamate receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
kainate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor activity IEA
Inferred from Electronic Annotation
more info
 
voltage-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
inhibitory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
inhibitory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
negative regulation of synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
nervous system development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of synaptic transmission, GABAergic ISO
Inferred from Sequence Orthology
more info
 
regulation of ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of short-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of short-term neuronal synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission, glutamatergic IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor complex IC
Inferred by Curator
more info
PubMed 
ionotropic glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor complex IPI
Inferred from Physical Interaction
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
neuronal postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutamate receptor ionotropic, kainate 1
Names
glutamate receptor subunit 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010348.3NP_034478.1  glutamate receptor ionotropic, kainate 1 isoform b precursor

    See identical proteins and their annotated locations for NP_034478.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is missing an in-frame coding exon at the 3' end compared to transcript variant 1, resulting in a shorter isoform (b) lacking a 29 aa segment compared to isoform a. RNA editing (CAG->CGG) changes Gln621Arg.
    Source sequence(s)
    AK046122, AK133667
    UniProtKB/TrEMBL
    Q3UZT1, Q8BQZ0
    Related
    ENSMUSP00000023652, ENSMUST00000023652
    Conserved Domains (4) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. NM_146072.4NP_666184.2  glutamate receptor ionotropic, kainate 1 isoform a precursor

    See identical proteins and their annotated locations for NP_666184.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). RNA editing (CAG->CGG) changes Gln621Arg.
    Source sequence(s)
    AK043542, AK046122, AK133667
    UniProtKB/TrEMBL
    Q3UZT1, Q8BQZ0, Q8BRT2
    Related
    ENSMUSP00000072107, ENSMUST00000072256
    Conserved Domains (5) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    pfam14575
    Location:823876
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    87895897..88290602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522919.2XP_006522982.1  

    Conserved Domains (5) summary
    pfam00060
    Location:435704
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:40254
    ANF_receptor; Receptor family ligand binding region
    pfam14575
    Location:696749
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl10011
    Location:40288
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:304673
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  2. XM_006522914.2XP_006522977.1  

    Conserved Domains (5) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    pfam14575
    Location:838891
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  3. XM_006522918.2XP_006522981.1  

    Conserved Domains (4) summary
    pfam00060
    Location:577787
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446790
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  4. XM_006522915.2XP_006522978.1  

    Conserved Domains (4) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  5. XM_006522916.2XP_006522979.1  

    Conserved Domains (4) summary
    pfam00060
    Location:577846
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446815
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  6. XM_006522917.2XP_006522980.1  

    See identical proteins and their annotated locations for XP_006522980.1

    Related
    ENSMUSP00000109773, ENSMUST00000114137
    Conserved Domains (4) summary
    pfam00060
    Location:562831
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431800
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  7. XM_006522920.2XP_006522983.1  

    Conserved Domains (3) summary
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35430
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:446600
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
  8. XM_006522921.2XP_006522984.1  

    See identical proteins and their annotated locations for XP_006522984.1

    UniProtKB/TrEMBL
    Q8C825
    Conserved Domains (3) summary
    pfam01094
    Location:54396
    ANF_receptor; Receptor family ligand binding region
    cl10011
    Location:35415
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    cl21456
    Location:431585
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_384929.2 RNA Sequence

  2. XR_384930.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    88093673..88486750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)