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Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) [ Mus musculus (house mouse) ]

Gene ID: 14800, updated on 8-May-2016
Official Symbol
Gria2provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA2 (alpha 2)provided by MGI
Primary source
MGI:MGI:95809
See related
Ensembl:ENSMUSG00000033981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluA2; Glur2; GluR-B; Glur-2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3 E3; 3 35.5 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (80684935..80803204, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (80488858..80606713, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40074 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene RIKEN cDNA A330069K06 gene Neighboring gene glycine receptor, beta subunit Neighboring gene polymerase (DNA directed), iota pseudogene Neighboring gene predicted gene, 29808

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
extracellular-glutamate-gated ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
receptor internalization ISO
Inferred from Sequence Orthology
more info
 
regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
dendritic spine ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
growth cone ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
terminal bouton ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutamate receptor 2
Names
AMPA selective glutamate receptor
AMPA-selective glutamate receptor 2
gluR-K2
glutamate receptor B
glutamate receptor ionotropic, AMPA 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039195.1NP_001034284.1  glutamate receptor 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs at the 3' end compared to transcript variant 1, and encodes a shorter isoform (3) with a distinct C-terminus compared to isoform 1. RNA editing (CAG->CGG) changes Gln607Arg.
    Source sequence(s)
    AC163349, AK046861
    UniProtKB/Swiss-Prot
    P23819
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545764
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413764
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  2. NM_001083806.1NP_001077275.1  glutamate receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077275.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform). RNA editing (CAG->CGG) changes Gln607Arg.
    Source sequence(s)
    AK045570, AK046861, AK134572, AK134647, AK163906, DN173316
    Consensus CDS
    CCDS38459.1
    UniProtKB/Swiss-Prot
    P23819
    UniProtKB/TrEMBL
    Q4LG64
    Related
    ENSMUSP00000103374, OTTMUSP00000069773, ENSMUST00000107745, OTTMUST00000130046
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  3. NM_013540.2NP_038568.2  glutamate receptor 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences. RNA editing (CAG->CGG) changes Gln607Arg.
    Source sequence(s)
    AC163349, AK046861, AK134572, DN173316
    Consensus CDS
    CCDS17423.1
    UniProtKB/Swiss-Prot
    P23819
    Related
    ENSMUSP00000074787, OTTMUSP00000069772, ENSMUST00000075316, OTTMUST00000130045
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    80684935..80803204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501012.2XP_006501075.1  

    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  2. XM_011240020.1XP_011238322.1  

    See identical proteins and their annotated locations for XP_011238322.1

    UniProtKB/TrEMBL
    E9QKC0
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  3. XM_006501013.2XP_006501076.1  

    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  4. XM_011240021.1XP_011238323.1  

    See identical proteins and their annotated locations for XP_011238323.1

    UniProtKB/TrEMBL
    G5E8H1
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545824
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  5. XM_006501014.1XP_006501077.1  

    Related
    ENSMUSP00000141447, OTTMUSP00000069774, ENSMUST00000192463, OTTMUST00000130047
    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545797
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  6. XM_006501015.2XP_006501078.1  

    Conserved Domains (4) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam00060
    Location:545763
    Lig_chan; Ligand-gated ion channel
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cd13715
    Location:413763
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
  7. XM_006501016.1XP_006501079.1  

    Conserved Domains (3) summary
    cd06389
    Location:28397
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
    pfam01094
    Location:56379
    ANF_receptor; Receptor family ligand binding region
    cl21456
    Location:413529
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RNA

  1. XR_375489.2 RNA Sequence

  2. XR_375488.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    80695789..80807271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)