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Gpx3 glutathione peroxidase 3 [ Mus musculus (house mouse) ]

Gene ID: 14778, updated on 24-May-2016
Official Symbol
Gpx3provided by MGI
Official Full Name
glutathione peroxidase 3provided by MGI
Primary source
MGI:MGI:105102
See related
Ensembl:ENSMUSG00000018339 Vega:OTTMUSG00000006337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPx; EGPx; GSHPx-3; GSHPx-P; AA960521
Summary
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is highly expressed in the kidney where it may play a role in protecting the kidney from oxidative damage. [provided by RefSeq, Feb 2012]
Orthologs
Location:
11; 11 B3-B5
Exon count:
5
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (54902854..54910382)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54716355..54723889)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene LYR motif containing 7 Neighboring gene predicted gene, 31490 Neighboring gene histidine triad nucleotide binding protein 1 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 40S ribosomal protein S11-like Neighboring gene annexin A6 Neighboring gene uncharacterized LOC102633930

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
glutathione binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
selenium binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutathione peroxidase 3
Names
GPx-3
GPx-P
extracellular GPx
plasma GPx
plasma glutathione peroxidase
NP_032187.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008161.3NP_032187.2  glutathione peroxidase 3 precursor

    See identical proteins and their annotated locations for NP_032187.2

    Status: REVIEWED

    Source sequence(s)
    AA062309, AK004942, BY061328
    Consensus CDS
    CCDS24703.1
    UniProtKB/Swiss-Prot
    P46412
    Related
    ENSMUSP00000081011, OTTMUSP00000006678, ENSMUST00000082430, OTTMUST00000014399
    Conserved Domains (1) summary
    cd00340
    Location:39211
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    54902854..54910382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    59492256..59499802
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001083929.1: Suppressed sequence

    Description
    NM_001083929.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.