Display Settings:

Format

Send to:

Choose Destination

Gpx1 glutathione peroxidase 1 [ Mus musculus (house mouse) ]

Gene ID: 14775, updated on 20-Jan-2015
Official Symbol
Gpx1provided by MGI
Official Full Name
glutathione peroxidase 1provided by MGI
Primary source
MGI:MGI:104887
See related
Ensembl:ENSMUSG00000063856; Vega:OTTMUSG00000050754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpx; CGPx; GPx-1; GSHPx-1; AI195024; AL033363
Summary
This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Orthologs
See Gpx1 in Epigenomics, MapViewer
Location:
9 F1; 9 59.24 cM
Exon count:
2
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 9 NC_000075.6 (108339080..108340342)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia translocation altered gene Neighboring gene ras homolog gene family, member A Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
glutathione binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IEA
Inferred from Electronic Annotation
more info
 
phospholipid-hydroperoxide glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
selenium binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
UV protection ISO
Inferred from Sequence Orthology
more info
 
angiogenesis involved in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis ISO
Inferred from Sequence Orthology
more info
 
endothelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart contraction ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
interaction with symbiont IGI
Inferred from Genetic Interaction
more info
PubMed 
intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
myotube differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein oxidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
 
regulation of mammary gland epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation IGI
Inferred from Genetic Interaction
more info
PubMed 
response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to hydroperoxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipid hydroperoxide ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to selenium ion ISO
Inferred from Sequence Orthology
more info
 
response to symbiotic bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
temperature homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasodilation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Lewy body ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutathione peroxidase 1
Names
glutathione peroxidase 1
cellular glutathione peroxidase
selenium-dependent glutathione peroxidase 1
NP_032186.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008160.6NP_032186.2  glutathione peroxidase 1

    See proteins identical to NP_032186.2

    Status: REVIEWED

    Source sequence(s)
    BC086649, CK628430
    Consensus CDS
    CCDS23522.1
    UniProtKB/Swiss-Prot
    P11352
    Related
    ENSMUSP00000081010, OTTMUSP00000069174, ENSMUST00000082429, OTTMUST00000128632
    Conserved Domains (1) summary
    cd00340
    Location:13190
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000075.6 

    Range
    108339080..108340342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000031.1 

    Range
    107948182..107949444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)