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CST1 cystatin SN [ Homo sapiens (human) ]

Gene ID: 1469, updated on 26-May-2016
Official Symbol
CST1provided by HGNC
Official Full Name
cystatin SNprovided by HGNC
Primary source
HGNC:HGNC:2473
See related
Ensembl:ENSG00000170373 HPRD:00460; MIM:123855; Vega:OTTHUMG00000032085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]
Location:
20p11.21
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (23747553..23750937, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23728190..23731574, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene cystatin SA pseudogene 1 Neighboring gene uncharacterized LOC105372574 Neighboring gene cystatin pseudogene 2 Neighboring gene uncharacterized LOC105372575

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Products Interactant Other Gene Complex Source Pubs Description
Preferred Names
cystatin-SN
Names
cystain-SA-I
cystatin 1
cystatin SA-I
cystatin-1
cysteine proteinase inhibitor, type 2 family
salivary cystatin-SA-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001898.2NP_001889.2  cystatin-SN precursor

    See identical proteins and their annotated locations for NP_001889.2

    Status: REVIEWED

    Source sequence(s)
    BC021225
    Consensus CDS
    CCDS13160.1
    UniProtKB/Swiss-Prot
    P01037
    Related
    ENSP00000305731, OTTHUMP00000030444, ENST00000304749, OTTHUMT00000078351
    Conserved Domains (1) summary
    cd00042
    Location:32138
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    23747553..23750937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    23728218..23731604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)