Gnb1 guanine nucleotide binding protein (G protein), beta 1 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Gnb1provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), beta 1provided by MGI
Primary source: MGI:95781
Locus tag: RP23-183D11.1
See related: Ensembl:ENSMUSG00000029064; Vega:OTTMUSG00000010708
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gnb-1; C77571; AA409223

Genomic context

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Location :: 4 E2; 4 86.17 cM

Sequence :: Chromosome: 4; NC_000070.6 (155491361..155559269)

See Gnb1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin
Title: Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction.
Title: G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
Title: The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.
Our data suggest that the G-protein beta(1)gamma(2) dimer may play an important regulatory role in skeletal muscle excitation-contraction coupling.
Title: In vivo expression of G-protein beta1gamma2 dimer in adult mouse skeletal muscle alters L-type calcium current and excitation-contraction coupling.
G protein subunits beta1 and beta2 have different roles in neutrophil function, as revealed by gene expression silencing in primary mouse neutrophils
Title: Different roles of G protein subunits beta1 and beta2 in neutrophil function revealed by gene expression silencing in primary mouse neutrophils.
Gbeta1 is required for normal embryonic neurogenesis.
Title: Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.
Gbeta1-mediated Fyn activation integrates FAK with AJ, preventing persistent endothelial barrier leakiness.
Title: The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Gbeta1 is the predominant Gbeta subunit expressed in olfactory sensory neurons.
Title: Ric-8B interacts with G alpha olf and G gamma 13 and co-localizes with G alpha olf, G beta 1 and G gamma 13 in the cilia of olfactory sensory neurons.
signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018.
Title: Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42.
G protein betagamma subunits stimulate type V and VI adenylyl cyclases
Title: Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits.

Submit: New GeneRIF Correction See all (11)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:199976	BioGRID:106624	ADCY5	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:199976	BioGRID:106625	ADCY6	BioGRID	PubMed	Two-hybrid
BioGRID:199976	BioGRID:225525	Adrbk1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199976	BioGRID:230528	Aph1a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199976	BioGRID:228950	Aph1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199976	BioGRID:198400	Btk	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199976	BioGRID:198516	Cav3	BioGRID	PubMed	Co-fractionation
BioGRID:199976	BioGRID:199255	Dync1i1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199976	BioGRID:199970	Gnao1	BioGRID	PubMed	Reconstituted Complex
BioGRID:199976	BioGRID:199978	Gnb2l1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:199976	BioGRID:199986	Gng2	BioGRID	PubMed	Reconstituted Complex
BioGRID:199976	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199976	BioGRID:202389	Prnp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:199976	BioGRID:112506	SNCA	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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ADP signalling through P2Y purinoceptor 1, organism-specific biosystem (from REACTOME)
ADP signalling through P2Y purinoceptor 1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ADP signalling through P2Y purinoceptor 12, organism-specific biosystem (from REACTOME)
ADP signalling through P2Y purinoceptor 12, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of G protein gated Potassium channels, organism-specific biosystem (from REACTOME)
Activation of G protein gated Potassium channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of GABAB receptors, organism-specific biosystem (from REACTOME)
Activation of GABAB receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem (from REACTOME)
Activation of Kainate Receptors upon glutamate binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alcoholism, organism-specific biosystem (from KEGG)
Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Alcoholism, conserved biosystem (from KEGG)
Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
Aquaporin-mediated transport, organism-specific biosystem (from REACTOME)
Aquaporin-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
Circadian entrainment, organism-specific biosystem (from KEGG)
Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Circadian entrainment, conserved biosystem (from KEGG)
Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
Class B/2 (Secretin family receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
G alpha (12/13) signalling events, organism-specific biosystem (from REACTOME)
G alpha (12/13) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
G alpha (z) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PI3Kgamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G beta:gamma signalling through PLC beta, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PLC beta, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G protein gated Potassium channels, organism-specific biosystem (from REACTOME)
G protein gated Potassium channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein activation, organism-specific biosystem (from REACTOME)
G-protein activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
G-protein beta:gamma signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABA B receptor activation, organism-specific biosystem (from REACTOME)
GABA B receptor activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABA receptor activation, organism-specific biosystem (from REACTOME)
GABA receptor activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABAergic synapse, organism-specific biosystem (from KEGG)
GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GABAergic synapse, conserved biosystem (from KEGG)
GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glucagon signaling in metabolic regulation, organism-specific biosystem (from REACTOME)
Glucagon signaling in metabolic regulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
Glucagon-type ligand receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glutamatergic synapse, organism-specific biosystem (from KEGG)
Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Glutamatergic synapse, conserved biosystem (from KEGG)
Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, organism-specific biosystem (from REACTOME)
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inhibition of Insulin Secretion by Adrenaline/Noradrenaline, organism-specific biosystem (from REACTOME)
Inhibition of Insulin Secretion by Adrenaline/Noradrenaline, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inwardly rectifying K+ channels, organism-specific biosystem (from REACTOME)
Inwardly rectifying K+ channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Morphine addiction, organism-specific biosystem (from KEGG)
Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Morphine addiction, conserved biosystem (from KEGG)
Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
Neuronal System, organism-specific biosystem (from REACTOME)
Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Olfactory Signaling Pathway, organism-specific biosystem (from REACTOME)
Olfactory Signaling Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Opioid Signalling, organism-specific biosystem (from REACTOME)
Opioid Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Phototransduction, organism-specific biosystem (from KEGG)
Phototransduction, organism-specific biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
Phototransduction, conserved biosystem (from KEGG)
Phototransduction, conserved biosystemPhototransduction is a biochemical process by which the photoreceptor cells generate electrical signals in response to captured photons. The vertebrate cascade starts with the absorption of photons b...
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet homeostasis, organism-specific biosystem (from REACTOME)
Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Potassium Channels, organism-specific biosystem (from REACTOME)
Potassium Channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Presynaptic function of Kainate receptors, organism-specific biosystem (from REACTOME)
Presynaptic function of Kainate receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prostacyclin signalling through prostacyclin receptor, organism-specific biosystem (from REACTOME)
Prostacyclin signalling through prostacyclin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Glucagon-like Peptide-1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Water Balance by Renal Aquaporins, organism-specific biosystem (from REACTOME)
Regulation of Water Balance by Renal Aquaporins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal amplification, organism-specific biosystem (from REACTOME)
Signal amplification, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Taste transduction, organism-specific biosystem (from KEGG)
Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
Taste transduction, conserved biosystem (from KEGG)
Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystem (from REACTOME)
Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Thromboxane signalling through TP receptor, organism-specific biosystem (from REACTOME)
Thromboxane signalling through TP receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
Transmission across Chemical Synapses, organism-specific biosystemcomputationally inferred pathway (not manually curated)
estrogen signalling, organism-specific biosystem (from WikiPathways)
estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17&amp;#x3b2;-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...

General gene information

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Markers

UniSTS:496680 (e-PCR)
- UniSTS:496680

Gnb1 (e-PCR), detects polymorphism
- UniSTS:496680

RH126184 (e-PCR)
- UniSTS:162892

RH127715 (e-PCR)
- UniSTS:211025

RH124831 (e-PCR)
- UniSTS:161653

Gnb1 (e-PCR), detects polymorphism
- UniSTS:143228

AA900898 (e-PCR)
- UniSTS:226203

PMC197251P1 (e-PCR)
- UniSTS:271850

NoName (e-PCR)
- UniSTS:236533

Homology

Homologs of the Gnb1 gene: The Gnb1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, M.oryzae, and N.crassa.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to G-protein coupled receptor binding	ISO Inferred from Sequence Orthology more info
GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
GTPase binding	ISO Inferred from Sequence Orthology more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
contributes_to type 1 angiotensin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
G-protein coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
G-protein coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
GTP catabolic process	ISA Inferred from Sequence Alignment more info	PubMed
GTP catabolic process	ISO Inferred from Sequence Orthology more info
cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
cell proliferation	IDA Inferred from Direct Assay more info	PubMed
cellular response to hypoxia	ISO Inferred from Sequence Orthology more info	PubMed
elevation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
phospholipase C-activating G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
phototransduction, visible light	ISA Inferred from Sequence Alignment more info	PubMed
retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info
sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell body	ISO Inferred from Sequence Orthology more info
dendrite	ISO Inferred from Sequence Orthology more info
heterotrimeric G-protein complex	IPI Inferred from Physical Interaction more info	PubMed
heterotrimeric G-protein complex	ISA Inferred from Sequence Alignment more info	PubMed
heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info
photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; transducin beta chain 1; guanine nucleotide binding protein, beta 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160016.1 → NP_001153488.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-3 encode the same the protein.

Source sequence(s)

AK163844, AL627405, AL670227, U29055

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70

Related

ENSMUSP00000030940, OTTMUSP00000011446, ENSMUST00000030940, OTTMUST00000024981

Conserved Domains (2) summary

COG2319
Location:49 – 340
Blast Score: 357

COG2319; FOG: WD40 repeat [General function prediction only]

cd00200
Location:48 – 340
Blast Score: 664

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001160017.1 → NP_001153489.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, compared to variant 1. Variants 1-3 encode the same the protein.

Source sequence(s)

AL627405, AL670227, BG807492, U29055

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70

Related

ENSMUSP00000101241, OTTMUSP00000055795, ENSMUST00000105616, OTTMUST00000099383

Conserved Domains (2) summary

COG2319
Location:49 – 340
Blast Score: 357

COG2319; FOG: WD40 repeat [General function prediction only]

cd00200
Location:48 – 340
Blast Score: 664

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_008142.4 → NP_032168.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same the protein.

Source sequence(s)

AK163844, AL627405, AL670227

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70

Related

ENSMUSP00000130123, ENSMUST00000165335

Conserved Domains (2) summary

COG2319
Location:49 – 340
Blast Score: 357

COG2319; FOG: WD40 repeat [General function prediction only]

cd00200
Location:48 – 340
Blast Score: 664

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38.p1 C57BL/6J

Range

155491361..155559269

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

157766104..157834163

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01032987.1	None
genomic	AAHY01032988.1	None
genomic	AAHY01032989.1	None
genomic	AB042854.2	BAB63904.1	129/Sv
genomic	AB066210.1	None	129/SvJ
genomic	AL627405.17 (1550..57706)	None
genomic	AL670227.7 (208221..219973)	None
genomic	CH466594.1	EDL15010.1	mixed
		EDL15011.1	mixed
		EDL15012.1	mixed
mRNA	AB246709.1	BAE75861.1	C57BL/6
mRNA	AB246710.1	BAE75862.1	C3H/HeJ
mRNA	AK156101.1	BAE33588.1	NOD
mRNA	AK163844.1	BAE37515.1	C57BL/6J
mRNA	AK177167.1	None
mRNA	AK177796.1	None
mRNA	AK178125.1	None
mRNA	AK180196.1	None
mRNA	AK180796.1	None
mRNA	AK180913.1	None
mRNA	AK182351.1	None
mRNA	AK183524.1	None
mRNA	AK187165.1	None
mRNA	AK188778.1	None
mRNA	AK190349.1	None
mRNA	AK191980.1	None
mRNA	AK194739.1	None
mRNA	AK198923.1	None
mRNA	AK199789.1	None
mRNA	AK200062.1	None
mRNA	AK203879.1	None
mRNA	AK205062.1	None
mRNA	AK209108.1	None
mRNA	AK213242.1	None
mRNA	AK217766.1	None
mRNA	AK218112.1	None
mRNA	AK218999.1	None
mRNA	AK219535.1	None
mRNA	BC003294.1	None	FVB/N
mRNA	BC013058.1	AAH13058.1	FVB/N
mRNA	BG807492.1	None
mRNA	U29055.1	AAC52905.1
mRNA	X62634.1	CAA44500.1	Swiss Webster