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Gnas GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus [ Mus musculus (house mouse) ]

Gene ID: 14683, updated on 5-Jul-2015
Official Symbol
Gnasprovided by MGI
Official Full Name
GNAS (guanine nucleotide binding protein, alpha stimulating) complex locusprovided by MGI
Primary source
MGI:MGI:95777
See related
Ensembl:ENSMUSG00000027523; Vega:OTTMUSG00000016388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P1; P2; P3; GSP; Gsa; POH; GPSA; Nesp; SCG6; Gnas1; Nespl; PHP1A; PHP1B; Gnasxl; Nesp55; Oedsml; Galphas; Oed-Sml; Gs-alpha; 5530400H20Rik; A930027G11Rik; C130027O20Rik
Summary
This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, which is commonly found in imprinted genes and correlates with transcript expression. This gene has an antisense transcript. One of the transcripts produced from this locus, and the antisense transcript, are both paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Additional transcript variants have been found for this gene, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2015]
Orthologs
See Gnas in Epigenomics, MapViewer
Location:
2 97.89 cM; 2 E1-H3
Exon count:
22
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (174283444..174346744)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (174109821..174172245)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene microRNA 296 Neighboring gene microRNA 298 Neighboring gene neuroendocrine secretory protein antisense Neighboring gene predicted gene, 30189 Neighboring gene negative elongation factor complex member C/D, Th1l Neighboring gene predicted gene, 40014 Neighboring gene cathepsin Z

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Alcoholism, organism-specific biosystem (from KEGG)
    Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Alcoholism, conserved biosystem (from KEGG)
    Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Aquaporin-mediated transport, organism-specific biosystem (from REACTOME)
    Aquaporin-mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Class B/2 (Secretin family receptors), organism-specific biosystem (from REACTOME)
    Class B/2 (Secretin family receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cocaine addiction, organism-specific biosystem (from KEGG)
    Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Cocaine addiction, conserved biosystem (from KEGG)
    Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Estrogen signaling pathway, organism-specific biosystem (from KEGG)
    Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • Estrogen signaling pathway, conserved biosystem (from KEGG)
    Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (z) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Gap junction, organism-specific biosystem (from KEGG)
    Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gap junction, conserved biosystem (from KEGG)
    Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Glucagon signaling in metabolic regulation, organism-specific biosystem (from REACTOME)
    Glucagon signaling in metabolic regulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystem (from REACTOME)
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Glucagon-type ligand receptors, organism-specific biosystem (from REACTOME)
    Glucagon-type ligand receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • GnRH signaling pathway, organism-specific biosystem (from KEGG)
    GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • GnRH signaling pathway, conserved biosystem (from KEGG)
    GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
  • Hedgehog 'off' state, organism-specific biosystem (from REACTOME)
    Hedgehog 'off' state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Integration of energy metabolism, organism-specific biosystem (from REACTOME)
    Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Long-term depression, organism-specific biosystem (from KEGG)
    Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Long-term depression, conserved biosystem (from KEGG)
    Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
  • Melanogenesis, organism-specific biosystem (from KEGG)
    Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Melanogenesis, conserved biosystem (from KEGG)
    Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
    Myometrial Relaxation and Contraction Pathways
  • Ovarian steroidogenesis, organism-specific biosystem (from KEGG)
    Ovarian steroidogenesis, organism-specific biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Ovarian steroidogenesis, conserved biosystem (from KEGG)
    Ovarian steroidogenesis, conserved biosystemThe ovarian steroids, 17-beta estradiol (E2) and progesterone (P4), are critical for normal uterine function, establishment and maintenance of pregnancy, and mammary gland development. Furthermore, t...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • PKA activation in glucagon signalling, organism-specific biosystem (from REACTOME)
    PKA activation in glucagon signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Prostacyclin signalling through prostacyclin receptor, organism-specific biosystem (from REACTOME)
    Prostacyclin signalling through prostacyclin receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Regulation of insulin secretion, organism-specific biosystem (from REACTOME)
    Regulation of insulin secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Salivary secretion, organism-specific biosystem (from KEGG)
    Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Salivary secretion, conserved biosystem (from KEGG)
    Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hedgehog, organism-specific biosystem (from REACTOME)
    Signaling by Hedgehog, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
  • Thyroid hormone synthesis, organism-specific biosystem (from KEGG)
    Thyroid hormone synthesis, organism-specific biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Thyroid hormone synthesis, conserved biosystem (from KEGG)
    Thyroid hormone synthesis, conserved biosystemThyroid hormones triiodothyronine (T3) and thyroxine (T4) are essential for normal development, growth and metabolic homeostasis in all vertebrates, and synthesized in the thyroid gland. The function...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
    Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vascular smooth muscle contraction, conserved biosystem (from KEGG)
    Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
  • Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystem (from REACTOME)
    Vasopressin regulates renal water homeostasis via Aquaporins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Vasopressin-regulated water reabsorption, organism-specific biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, organism-specific biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • Vasopressin-regulated water reabsorption, conserved biosystem (from KEGG)
    Vasopressin-regulated water reabsorption, conserved biosystemIn the kidney, the antidiuretic hormone vasopressin (AVP) is a critical regulator of water homeostasis by controlling the water movement from lumen to the interstitium for water reabsorption and adju...
  • cAMP signaling, organism-specific biosystem (from KEGG)
    cAMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • cAMP signaling, conserved biosystem (from KEGG)
    cAMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • estrogen signalling, organism-specific biosystem (from WikiPathways)
    estrogen signalling, organism-specific biosystemEstrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear h...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC118029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D1 dopamine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein beta-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
GTP binding ISO
Inferred from Sequence Orthology
more info
 
GTPase activity ISA
Inferred from Sequence Alignment
more info
PubMed 
GTPase activity TAS
Traceable Author Statement
more info
PubMed 
alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
 
beta-2 adrenergic receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
corticotropin-releasing hormone receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
corticotropin-releasing hormone receptor 1 binding ISO
Inferred from Sequence Orthology
more info
 
guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mu-type opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
mu-type opioid receptor binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transducer activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adenylate cyclase-activating dopamine receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
adenylate cyclase-activating dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
bone development ISO
Inferred from Sequence Orthology
more info
 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to catecholamine stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to prostaglandin E stimulus ISO
Inferred from Sequence Orthology
more info
 
cognition ISO
Inferred from Sequence Orthology
more info
 
developmental growth ISO
Inferred from Sequence Orthology
more info
 
embryonic cranial skeleton morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endochondral ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
energy reserve metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle placode formation ISO
Inferred from Sequence Orthology
more info
 
multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of renal sodium excretion ISO
Inferred from Sequence Orthology
more info
 
platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to parathyroid hormone ISO
Inferred from Sequence Orthology
more info
 
sensory perception of chemical stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin development IMP
Inferred from Mutant Phenotype
more info
PubMed 
tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
heterotrimeric G-protein complex ISA
Inferred from Sequence Alignment
more info
PubMed 
heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
 
heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 
intrinsic component of membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with sarcolemma ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein ALEX; protein GNAS; protein SCG6 (secretogranin VI)
Names
Gs alpha subunit
adenylate cyclase-stimulating G alpha protein
alternative gene product encoded by XL-exon
extra large alphas protein
guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
neuroendocrine secretory protein 55
secretogranin VI
stimulatory G-protein alpha subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077507.2NP_001070975.1  protein GNAS isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as GNASXL) is paternally expressed. It has an alternate 5' exon, lacks an internal exon and uses an alternate splice site in the coding region, compared to variant 7. It encodes isoform f (also known as XLas), which has a longer and distinct N-terminus and lacks an internal segment, compared to isoform GNASL. Isoform f is the neuroendocrine-specific G-protein alpha subunit.
    Source sequence(s)
    AF116268, AK030489, AL593857, BU516278
    Consensus CDS
    CCDS38354.1
    UniProtKB/Swiss-Prot
    P63094
    UniProtKB/Swiss-Prot
    Q6R0H7
    Related
    ENSMUSP00000085184, OTTMUSP00000018559, ENSMUST00000087876, OTTMUST00000041362
    Conserved Domains (2) summary
    cd00066
    Location:7801113
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:7591116
    G_alpha; G protein alpha subunit
  2. NM_001077510.4NP_001070978.1  protein GNAS isoform GNASS

    See identical proteins and their annotated locations for NP_001070978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is biallelically expressed. It lacks an internal exon and uses an alternate splice site, compared to variant 7. It encodes the isoform GNASS, also known as alpha-S1, which lacks an internal segment and has two amino acids different, compared to isoform GNASL.
    Source sequence(s)
    AK159563, BC062654, BU054033, DV057819
    Consensus CDS
    CCDS38357.1
    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000104713, OTTMUSP00000017945, ENSMUST00000109085, OTTMUST00000040193
    Conserved Domains (2) summary
    cd00066
    Location:41374
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:20377
    G_alpha; G protein alpha subunit
  3. NM_001310083.1NP_001297012.1  protein GNAS isoform GNASL

    See identical proteins and their annotated locations for NP_001297012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, compared to variant 7. Variants 7 and 10 encode the same isoform guanine nucleotide binding protein alpha-s long (GNASL, also known as alpha-S2), a form of the G-protein alpha subunit.
    Source sequence(s)
    BC062654, BM944582, BU516278
  4. NM_001310085.1NP_001297014.1  protein GNAS XXLb2

    See identical proteins and their annotated locations for NP_001297014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) is paternally expressed and includes an alternate 5' exon structure, compared to variant 7. This variant is reported in PMID:15148396. It encodes isoform XXLb2, which has a distinct and shorter C-terminus, compared to isoform XLas.
    Source sequence(s)
    AK030489, AK132636, AL593857, BU516278
    Conserved Domains (2) summary
    smart00275
    Location:759786
    G_alpha; G protein alpha subunit
    PRK12323
    Location:330531
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
  5. NM_010309.4NP_034439.2  protein GNAS isoform XLas

    See identical proteins and their annotated locations for NP_034439.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, compared to variant 7. This variant includes two overlapping open reading frames encoding distinct isoforms XLas and Alex, respectively. This RefSeq represents the isoform XLas (also known as alpha sXXL), which is a neuroendocrine-specific G-protein alpha subunit. It has a distinct and longer N-terminus, compared to isoform GNASL.
    Source sequence(s)
    AK132636, AL593857, BU516278
    Consensus CDS
    CCDS17151.1
    UniProtKB/Swiss-Prot
    P63094
    UniProtKB/Swiss-Prot
    Q6R0H7
    Related
    ENSMUSP00000140174, ENSMUST00000185956
    Conserved Domains (2) summary
    cd00066
    Location:7801127
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:7591130
    G_alpha; G protein alpha subunit
  6. NM_019690.3NP_062664.2  protein SCG6 (secretogranin VI) isoform SCG6 precursor

    See identical proteins and their annotated locations for NP_062664.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is maternally expressed. It lacks several 3' exons and has alternate 5' and 3' exons, compared to variant 7. Variants 3 and 4 both encode isoform secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 3 and 4 do not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript NESPAS.
    Source sequence(s)
    AJ010163, AL593857, AV353621, BB632851, BX636499, BY600941, BY718446, CF730992
    Consensus CDS
    CCDS17149.1
    UniProtKB/Swiss-Prot
    Q9Z0F1
    Related
    ENSMUSP00000136180, ENSMUST00000180362
    Conserved Domains (1) summary
    pfam06390
    Location:1253
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  7. NM_022000.3NP_068840.2  protein SCG6 (secretogranin VI) isoform SCG6 precursor

    See identical proteins and their annotated locations for NP_068840.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is maternally expressed and has alternate 5' exons, compared to variant 7. Variants 3 and 4 both encode isoform secretogranin VI (SCG6, also known as NESP55), which localizes to large secretory vesicles of endocrine cells and neurons. The coding regions of variants 3 and 4 do not overlap the coding regions used by other transcripts; thus SCG6 has no similarity to isoforms of the G-protein alpha subunit. This variant has an antisense transcript NESPAS.
    Source sequence(s)
    AJ010163, AK039035, AK132636, BU516278
    Consensus CDS
    CCDS17149.1
    UniProtKB/Swiss-Prot
    P63094
    UniProtKB/Swiss-Prot
    Q9Z0F1
    Related
    ENSMUSP00000104724, OTTMUSP00000029714, ENSMUST00000109096, OTTMUST00000039465
    Conserved Domains (1) summary
    pfam06390
    Location:1253
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  8. NM_201616.2NP_963910.1  protein GNAS isoform GNASL

    See identical proteins and their annotated locations for NP_963910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is biallelically expressed and encodes guanine nucleotide binding protein alpha-s long (GNASL) isoform, also known as alpha-S2, a form of the G-protein alpha subunit. Variants 7 and 10 encode the same isoform (GNASL).
    Source sequence(s)
    AK159563, AK168996, BU516278, CK625094
    Consensus CDS
    CCDS38356.1
    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000104715, ENSMUST00000109087
    Conserved Domains (2) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:20391
    G_alpha; G protein alpha subunit
  9. NM_201617.2NP_963911.1  protein GNAS isoform XXLb1

    See identical proteins and their annotated locations for NP_963911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is paternally expressed. Its 5' exon overlaps with variant 1 and none of its sequence overlaps with variant 7. This variant encodes isoform XXLb1, which has a distinct and shorter C-terminus, compared to isoform XLas. This variant is based on data in PMID:15148396.
    Source sequence(s)
    AK030489, AL593857
    Consensus CDS
    CCDS38355.1
    UniProtKB/Swiss-Prot
    Q6R0H6
    UniProtKB/Swiss-Prot
    Q6R0H7
    Conserved Domains (2) summary
    smart00275
    Location:759786
    G_alpha; G protein alpha subunit
    PRK12323
    Location:330531
    PRK12323; DNA polymerase III subunits gamma and tau; Provisional
  10. NM_201618.2NP_963912.1  protein ALEX isoform Alex

    See identical proteins and their annotated locations for NP_963912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as GNASXL) is paternally expressed. It includes an alternate 5' exon, compared to variant 7. This variant includes two overlapping open reading frames encoding XLas and Alex, respectively. This RefSeq represents isoform Alex (also known as alexX), which has no similarity to other isoforms encoded by this gene. It interacts with isoform XLas, and their interaction is essential for G-protein signaling in neuroendocrine cells.
    Source sequence(s)
    AK132636, AL593857, BU516278
    Consensus CDS
    CCDS50817.1
    UniProtKB/Swiss-Prot
    P63094
    UniProtKB/Swiss-Prot
    Q6R0H6
    Related
    ENSMUSP00000139839, ENSMUST00000186907
    Conserved Domains (1) summary
    pfam09770
    Location:337532
    PAT1; Topoisomerase II-associated protein PAT1

RNA

  1. NR_003258.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as Exon1A) is paternally expressed and has two alternate 5' exons, compared to variant 7. This variant is represented as non-coding because it lacks a portion of the coding region, including the translational start codon, found in variant 7. This variant is described in PMID:19412439 and it may regulate imprinting of the GNAS transcripts.
    Source sequence(s)
    BC062654

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    174283444..174346744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498779.2XP_006498842.1  

    See identical proteins and their annotated locations for XP_006498842.1

    UniProtKB/Swiss-Prot
    Q9Z0F1
    Conserved Domains (1) summary
    pfam06390
    Location:1253
    NESP55; Neuroendocrine-specific golgi protein P55 (NESP55)
  2. XM_006498777.1XP_006498840.1  

    Conserved Domains (2) summary
    cd00066
    Location:5357
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:5360
    G_alpha; G protein alpha subunit
  3. XM_006498778.1XP_006498841.1  

    Conserved Domains (2) summary
    cd00066
    Location:5341
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:5344
    G_alpha; G protein alpha subunit
  4. XM_006498780.1XP_006498843.1  

    Conserved Domains (2) summary
    cd00066
    Location:7801112
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:7591115
    G_alpha; G protein alpha subunit
  5. XM_006498775.1XP_006498838.1  

    UniProtKB/Swiss-Prot
    P63094
    Related
    ENSMUSP00000085179, OTTMUSP00000017631, ENSMUST00000087871, OTTMUST00000039460
    Conserved Domains (2) summary
    cd00066
    Location:41388
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:20391
    G_alpha; G protein alpha subunit
  6. XM_006498774.1XP_006498837.1  

    Conserved Domains (2) summary
    cd00066
    Location:41389
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:20392
    G_alpha; G protein alpha subunit
  7. XM_006498776.1XP_006498839.1  

    UniProtKB/TrEMBL
    Z4YKV1
    Related
    ENSMUSP00000104712, OTTMUSP00000017948, ENSMUST00000109084, OTTMUST00000040196
    Conserved Domains (2) summary
    cd00066
    Location:41373
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:20376
    G_alpha; G protein alpha subunit

RNA

  1. XR_374415.2 RNA Sequence

  2. XR_374414.2 RNA Sequence

  3. XR_374413.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    180249319..180306988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_010310.1: Suppressed sequence

    Description
    NM_010310.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.