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    RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 [ Homo sapiens (human) ]

    Gene ID: 146713, updated on 13-Mar-2013
    Official Symbol
    RBFOX3provided by HGNC
    Official Full Name
    RNA binding protein, fox-1 homolog (C. elegans) 3provided by HGNC
    Primary source
    HGNC:27097
    Locus tag
    hCG_1776007
    See related
    Ensembl:ENSG00000167281; HPRD:18730; Vega:OTTHUMG00000150183
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FOX3; NEUN; FOX-3; HRNBP3
    Annotation information
    Annotation category: partial on reference assembly
    Location :
    17q25.3
    Sequence :
    Chromosome: 17; NC_000017.10 (77085427..77303909, complement)
    See RBFOX3 in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507410 Neighboring gene C1q and tumor necrosis factor related protein 1 Neighboring gene endo-beta-N-acetylglucosaminidase Neighboring gene microRNA 4739 Neighboring gene uncharacterized LOC100652929

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    2. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. Kim KK, et al. J Biol Chem, 2009 Nov 6. PMID 19713214.
    3. Homologues of the Caenorhabditis elegans Fox-1 protein are neuronal splicing regulators in mammals. Underwood JG, et al. Mol Cell Biol, 2005 Nov. PMID 16260614.
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See all (7) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    2. NeuN (neuronal nuclei) is a neuron-specific nuclear protein identified by anti-NeuN antibody, and widely used as the postmitotic neuron marker. NeuN is identified as the Fox-3 gene product by mass spectrometry, immunoblotting, RNAi, and immunostaining.
      Title: Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ56884, FLJ58356

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    RNA binding protein fox-1 homolog 3
    Names
    RNA binding protein fox-1 homolog 3
    fox-1 homolog C
    neuronal nuclei
    hexaribonucleotide binding protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082575.2 → NP_001076044.1  RNA binding protein fox-1 homolog 3

      Status: VALIDATED

      Source sequence(s)
      AC021534, AC055858, AC073624, AK293617, BU741507
      Consensus CDS
      CCDS45805.1
      UniProtKB/Swiss-Prot
      A6NFN3
      Related
      ENSP00000408395, ENST00000415831
      Conserved Domains (3) summary
      COG0724
      Location:30 – 232
      Blast Score: 189
      COG0724; RNA-binding proteins (RRM domain) [General function prediction only]
      cd00590
      Location:100 – 171
      Blast Score: 239
      RRM; RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA ...
      pfam12414
      Location:207 – 297
      Blast Score: 146
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p10 Primary Assembly

      Range
      77085427..77303909, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      72508346..72726906, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018928.1 Alternate CHM1_1.0

      Range
      78170786..78388805, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001025448.1: Suppressed sequence

      Description
      NM_001025448.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01002895.1 (72139..86579) None
    genomic ABBA01002896.1 None
    genomic ABBA01002897.1 None
    genomic ABBA01002898.1 None
    genomic ABBA01002899.1 None
    genomic ABBA01002900.1 None
    genomic ABBA01002901.1 None
    genomic AC020689.8 None
    genomic AC021534.19 None
    genomic AC055858.18 (43165..109678) None
    genomic AC073624.28 None
    genomic AMYH01008680.1 (7542..31110) None
    genomic AMYH01008681.1 None
    genomic CH471099.1 EAW89563.1
      EAW89564.1
    mRNA AK054893.1 None
    mRNA AK124644.1 None
    mRNA AK128131.1 None
    mRNA AK293617.1 BAG57077.1
    mRNA AK293905.1 BAG57290.1
    mRNA BC093713.1 AAH93713.1
    mRNA BM714144.1 None
    mRNA BU741507.1 None
    mRNA BX452143.2 None
    mRNA DN990270.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NFN3.4 GenPept UniProtKB/Swiss-Prot:A6NFN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • GAP
        GAP Links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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