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MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B [ Homo sapiens (human) ]

Gene ID: 146664, updated on 12-Apr-2014
Official Symbol
MGAT5Bprovided by HGNC
Official Full Name
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme Bprovided by HGNC
Primary source
HGNC:24140
See related
Ensembl:ENSG00000167889; HPRD:14392; MIM:612441; Vega:OTTHUMG00000177278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GnT-IX; GnT-VB
Summary
The MGAT5B gene encodes a beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.155) that functions in the synthesis of complex cell surface N-glycans (Kaneko et al., 2003 [PubMed 14623122]).[supplied by OMIM, Nov 2008]
Location :
17q25.2
Sequence :
Chromosome: 17; NC_000017.11 (76868716..76950393)
See MGAT5B in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928514 Neighboring gene uncharacterized LOC101928538 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene SEC14-like 1 (S. cerevisiae) Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20 (non-protein coding) Neighboring gene cytochrome c, somatic pseudogene 40

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
NHGRI GWA Catalog
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Env, gp160, envelope glycoprotein env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed
Envelope transmembrane glycoprotein gp41 env Mannose-containing, N-linked oligosaccharide side-chains of HIV-1 gp41 are involved in the initial stage of infection by HIV-1; glycosylation inhibitors block virus-cell and cell-cell fusion and release of the virions PubMed

Go to the HIV-1, Human Protein Interaction Database

  • N-Glycan biosynthesis, organism-specific biosystem (from KEGG)
    N-Glycan biosynthesis, organism-specific biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
  • N-Glycan biosynthesis, conserved biosystem (from KEGG)
    N-Glycan biosynthesis, conserved biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
  • N-glycan biosynthesis, complex type, organism-specific biosystem (from KEGG)
    N-glycan biosynthesis, complex type, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
  • N-glycan biosynthesis, complex type, conserved biosystem (from KEGG)
    N-glycan biosynthesis, complex type, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
  • Other types of O-glycan biosynthesis, organism-specific biosystem (from KEGG)
    Other types of O-glycan biosynthesis, organism-specific biosystemO-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or th...
  • Other types of O-glycan biosynthesis, conserved biosystem (from KEGG)
    Other types of O-glycan biosynthesis, conserved biosystemO-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
protein N-linked glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
Names
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
hGnTVb
glcNAc-T Vb
N-acetylglucosaminyltransferase IX
N-acetylglucosaminyl-transferase Vb
mannoside acetylglucosaminyltransferase 5B
beta(1,6)-N-acetylglucosaminyltransferase V
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B
NP_001186101.1
NP_653278.2
NP_945193.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199172.1NP_001186101.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 3

    See proteins identical to NP_001186101.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and contains an alternate in-frame exon compared to variant 2. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal 2 aa segment compared to isoform 2.
    Source sequence(s)
    AB235153, AW191036, BC063862
    Consensus CDS
    CCDS59299.1
    UniProtKB/Swiss-Prot
    Q3V5L5
    Related
    ENSP00000456037, OTTHUMP00000268986, ENST00000569840, OTTHUMT00000460624
    Conserved Domains (1) summary
    pfam15024
    Location:184777
    Blast Score: 2273
    Glyco_transf_18; Glycosyltransferase family 18
  2. NM_144677.2NP_653278.2  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 1

    See proteins identical to NP_653278.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AB109185, AB114297, AW191036, BC036948, BC041577
    Consensus CDS
    CCDS11751.1
    UniProtKB/Swiss-Prot
    Q3V5L5
    Related
    ENSP00000301618, OTTHUMP00000256268, ENST00000301618, OTTHUMT00000436084
    Conserved Domains (1) summary
    pfam15024
    Location:184775
    Blast Score: 2286
    Glyco_transf_18; Glycosyltransferase family 18
  3. NM_198955.1NP_945193.1  alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 2

    See proteins identical to NP_945193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AB109185, AB114297, AW191036, BC036948
    Consensus CDS
    CCDS45788.1
    UniProtKB/Swiss-Prot
    Q3V5L5
    Related
    ENSP00000391227, OTTHUMP00000256271, ENST00000428789, OTTHUMT00000436088
    Conserved Domains (1) summary
    pfam15024
    Location:195786
    Blast Score: 2284
    Glyco_transf_18; Glycosyltransferase family 18

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    76868716..76950393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257065.2XP_005257122.1  

    Conserved Domains (1) summary
    pfam15024
    Location:171720
    Blast Score: 2081
    Glyco_transf_18; Glycosyltransferase family 18
  2. XM_006721707.1XP_006721770.1  

    Conserved Domains (1) summary
    pfam15024
    Location:121714
    Blast Score: 2255
    Glyco_transf_18; Glycosyltransferase family 18
  3. XM_006721708.1XP_006721771.1  

    Conserved Domains (1) summary
    pfam15024
    Location:2421
    Blast Score: 1664
    Glyco_transf_18; Glycosyltransferase family 18

RNA

  1. XR_243634.2 RNA Sequence

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    70291842..70374370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    74929621..75011746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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