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    Glud1 glutamate dehydrogenase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14661, updated on 11-May-2013
    Official Symbol
    Glud1provided by MGI
    Official Full Name
    glutamate dehydrogenase 1provided by MGI
    Primary source
    MGI:95753
    See related
    Ensembl:ENSMUSG00000021794; Vega:OTTMUSG00000030736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Glud; Gdh-X; Gludl; AI118167
    Location :
    14 B; 14 20.8 cM
    Sequence :
    Chromosome: 14; NC_000080.6 (34310727..34345033)
    See Glud1 in Epigenomics, MapViewer

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 35, member A Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene predicted gene 6398 Neighboring gene B-cell CLL/lymphoma 7C pseudogene Neighboring gene family with sequence similarity 25, member C

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission. Frigerio F, et al. J Neurochem, 2012 Nov. PMID 22924626.
    2. Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase. Vetterli L, et al. Mol Biol Cell, 2012 Oct. PMID 22875990.
    3. Induction of excitatory and inhibitory presynaptic differentiation by GluD1. Ryu K, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22138648.
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    5. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611.

    See all (49) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Permissive levels of glutamate are required for the full development of glucose-stimulated insulin secretion and glutamate dehydrogenase plays an indispensable role in this process.
      Title: Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.
    2. Mice deficient in Glud1 exhibit deficient oxidative catabolism of glutamate in astrocytes, showing that GDH is required for Krebs cycle pathway; however, lack of GDH modifies metabolic handling of glutamate without altering synaptic transmission.
      Title: Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.
    3. These results suggest that GluD1 might contribute to the formation of specific synapses in the hippocampus such as those formed by the projecting neurons of the entorhinal cortex.
      Title: Induction of excitatory and inhibitory presynaptic differentiation by GluD1.
    4. Data show that Balb/c Glud1 transgenic mice had significantly increased depolarization-induced glutamate release compared with wild type littermates.
      Title: Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.
    5. In betaGlud1(-/-) mice, the reduced secretory capacity resulted in lower plasma insulin levels in response to both feeding and glucose load, while body weight gain was preserved
      Title: Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:199956 BioGRID:235913 Iqcb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199956 BioGRID:234431 Nphp4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:199956 BioGRID:116981 SIRT4    BioGRID  PubMed Biochemical Activity 
    BioGRID:199956 BioGRID:217445 Sirt4    BioGRID  PubMed Affinity Capture-Western 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NAD+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    glutamate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    glutamate dehydrogenase [NAD(P)+] activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    glutamate dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    leucine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cellular amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    glutamate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    glutamate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of insulin secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to aluminum ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    glutamate dehydrogenase 1, mitochondrial
    Names
    glutamate dehydrogenase 1, mitochondrial
    GDH 1
    NP_032159.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008133.4 → NP_032159.1  glutamate dehydrogenase 1, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AK089152, AK150637, AK161876
      Consensus CDS
      CCDS26935.1
      UniProtKB/Swiss-Prot
      P26443
      UniProtKB/TrEMBL
      Q3TSQ7
      Related
      ENSMUSP00000022322, OTTMUSP00000039999, ENSMUST00000022322, OTTMUST00000076096
      Conserved Domains (3) summary
      COG0334
      Location:82 – 555
      Blast Score: 927
      GdhA; Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]
      cd01076
      Location:263 – 548
      Blast Score: 882
      NAD_bind_1_Glu_DH; NAD(P) binding domain of glutamate dehydrogenase, subgroup 1
      pfam02812
      Location:112 – 240
      Blast Score: 505
      ELFV_dehydrog_N; Glu/Leu/Phe/Val dehydrogenase, dimerisation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p1 C57BL/6J

      Range
      34310727..34345033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000036.1 Alternate Mm_Celera

      Range
      30576520..30610613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01112784.1 None
    genomic AAHY01112785.1 None
    genomic AC160930.2 (84097..118253) None
    genomic CH466573.1 EDL24875.1 mixed
    mRNA AK075971.1 None C57BL/6J
    mRNA AK089152.1 BAC40767.1 C57BL/6J
    mRNA AK150637.1 None C57BL/6J
    mRNA AK161876.1 BAE36618.1 C57BL/6J
    mRNA AK181205.1 None
    mRNA AK207576.1 None
    mRNA AK209048.1 None
    mRNA AK213533.1 None
    mRNA AK213994.1 None
    mRNA AK217090.1 None
    mRNA AK219236.1 None
    mRNA AK219431.1 None
    mRNA BC052724.1 AAH52724.1 C57BL/6
    mRNA BC057347.1 AAH57347.1 C57BL/6
    mRNA EF437367.1 None C57BL/6J
    mRNA X57024.1 CAA40341.1 BALB/c
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26443.1 GenPept UniProtKB/Swiss-Prot:P26443

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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