My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    CSRP1 cysteine and glycine-rich protein 1 [ Homo sapiens ]

    Gene ID: 1465, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    CSRP1provided by HGNC
    Official Full Name
    cysteine and glycine-rich protein 1provided by HGNC
    Primary source
    HGNC:2469
    See related
    Ensembl:ENSG00000159176; HPRD:00470; MIM:123876; Vega:OTTHUMG00000035773
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRP; CRP1; CSRP; CYRP; D1S181E; DKFZp686M148
    Summary
    This gene encodes a member of the cysteine-rich protein (CSRP) family. This gene family includes a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this gene product occurs in proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
    Help top of page

    Genomic context

    Location :
    1q32
    Sequence :
    Chromosome: 1; NC_000001.10 (201452658..201476387, complement)
    See CSRP1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506573 Neighboring gene troponin I type 1 (skeletal, slow) Neighboring gene pleckstrin homology-like domain, family A, member 3 Neighboring gene ribosomal protein S10 pseudogene 7 Neighboring gene neuron navigator 1 Neighboring gene microRNA 1231

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. Martins-de-Souza D, et al. J Proteome Res, 2012 Apr 6. PMID 22360420.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis. Järvinen PM, et al. J Cell Physiol, 2012 Jun. PMID 21882188.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes. Latonen L, et al. Photodermatol Photoimmunol Photomed, 2010 Apr. PMID 20415737.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
      Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
    2. Results show that CRP1 is a novel TGF-beta1 regulated protein that is expressed in fibrotic lesions and may be relevant in idiopathic pulmonary fibrosis.
      Title: Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.
    3. CRP1 expression is regulated by UVB in human keratinocytes, suggesting a role for CRP1 in the phototoxic responses of human skin.
      Title: Ultraviolet B radiation regulates cysteine-rich protein 1 in human keratinocytes.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Hypomethylation of wingless-related MMTV integration site 5A (WNT5A), S100 calcium-binding protein P (S100P) and cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by bisulfite sequencing.
      Title: Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer.
    6. Aberrant methylation of CSRP1 is associated with hepatocellular carcinoma
      Title: Methylation status of genes upregulated by demethylating agent 5-aza-2'-deoxycytidine in hepatocellular carcinoma.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P21291 P12814 ACTN1    HPRD  PubMed  
    P21291 P21291 CSRP1    HPRD  PubMed  
    BioGRID:107847 BioGRID:107847 CSRP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107847 BioGRID:108276 EGFR    BioGRID  PubMed PCA 
    BioGRID:107847 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    cysteine and glycine-rich protein 1
    Names
    cysteine and glycine-rich protein 1
    LIM-domain protein
    cysteine-rich protein 1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193570.1 → NP_001180499.1  cysteine and glycine-rich protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC096677, AK302237, AW163500, BC032493
      UniProtKB/TrEMBL
      B4DY28
      UniProtKB/Swiss-Prot
      P21291
      Conserved Domains (2) summary
      cd09479
      Location:8 – 58
      Blast Score: 219
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)
      cl02475
      Location:119 – 165
      Blast Score: 199
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers.

    2. NM_001193571.1 → NP_001180500.1  cysteine and glycine-rich protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC096677, AK290133, BC032493
      Consensus CDS
      CCDS1413.1
      UniProtKB/TrEMBL
      A8K268
      UniProtKB/Swiss-Prot
      P21291
      UniProtKB/TrEMBL
      Q5U0J2
      Related
      ENSP00000436792, OTTHUMP00000228679, ENST00000533432, OTTHUMT00000382280
      Conserved Domains (2) summary
      cd09403
      Location:119 – 171
      Blast Score: 239
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 – 58
      Blast Score: 222
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    3. NM_001193572.1 → NP_001180501.1  cysteine and glycine-rich protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AC096677, AK293053, BC032493
      Consensus CDS
      CCDS1413.1
      UniProtKB/Swiss-Prot
      P21291
      UniProtKB/TrEMBL
      Q5U0J2
      Related
      ENSP00000434147, OTTHUMP00000228678, ENST00000532460, OTTHUMT00000382278
      Conserved Domains (2) summary
      cd09403
      Location:119 – 171
      Blast Score: 239
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 – 58
      Blast Score: 222
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    4. NM_004078.2 → NP_004069.1  cysteine and glycine-rich protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Variants 1, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AW163500, BC032493, CA411857, CF453919
      Consensus CDS
      CCDS1413.1
      UniProtKB/Swiss-Prot
      P21291
      UniProtKB/TrEMBL
      Q5U0J2
      Related
      ENSP00000345079, ENST00000340006
      Conserved Domains (2) summary
      cd09403
      Location:119 – 171
      Blast Score: 239
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 – 58
      Blast Score: 222
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      201452658..201476387, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      172618670..172642392, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144773.1: Suppressed sequence

      Description
      NM_001144773.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC096677.2 (81528..105118) None
    genomic CH471067.1 EAW91370.1
      EAW91371.1
    genomic M76378.1 AAA58431.1
    mRNA AB209756.1 BAD92993.1
    mRNA AK057876.1 None
    mRNA AK122812.1 BAG53741.1
    mRNA AK126445.1 None
    mRNA AK126507.1 None
    mRNA AK131508.1 BAD18652.1
    mRNA AK290133.1 BAF82822.1
    mRNA AK293053.1 BAF85742.1
    mRNA AK302237.1 BAG63590.1
    mRNA AK304415.1 BAG65246.1
    mRNA AW163500.1 None
    mRNA BC004265.1 AAH04265.1
    mRNA BC007492.2 None
    mRNA BC018806.1 None
    mRNA BC032493.1 AAH32493.1
    mRNA BT019520.1 AAV38327.1
    mRNA BX537488.1 CAH10559.1
    mRNA BX641046.1 None
    mRNA CA411857.1 None
    mRNA CF453919.1 None
    mRNA CR627407.1 CAH10496.1
    mRNA DA163062.1 None
    mRNA DA930181.1 None
    mRNA DB019080.1 None
    mRNA M33146.1 AAA35720.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21291.3 GenPept UniProtKB/Swiss-Prot:P21291
    Q59EQ5 GenPept UniProtKB/TrEMBL:Q59EQ5
    Q5U0J2 GenPept UniProtKB/TrEMBL:Q5U0J2
    Q6AI18 GenPept UniProtKB/TrEMBL:Q6AI18
    Q6AWD1 GenPept UniProtKB/TrEMBL:Q6AWD1
    Q6ZMS3 GenPept UniProtKB/TrEMBL:Q6ZMS3
    Q9BTA4 GenPept UniProtKB/TrEMBL:Q9BTA4
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...