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Glul glutamate-ammonia ligase (glutamine synthetase) [ Mus musculus (house mouse) ]

Gene ID: 14645, updated on 21-May-2016
Official Symbol
Glulprovided by MGI
Official Full Name
glutamate-ammonia ligase (glutamine synthetase)provided by MGI
Primary source
MGI:MGI:95739
See related
Ensembl:ENSMUSG00000026473 Vega:OTTMUSG00000016462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GS; Glns
Orthologs
Location:
1; 1 G2
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (153899929..153909723)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (155747075..155756844)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene transmembrane epididymal protein 1A Neighboring gene predicted gene, 38440 Neighboring gene microRNA 8114 Neighboring gene predicted gene, 30327 Neighboring gene predicted gene, 30243

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
dynein light chain binding ISO
Inferred from Sequence Orthology
more info
 
glutamate binding ISO
Inferred from Sequence Orthology
more info
 
glutamate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
glutamate-ammonia ligase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ammonia assimilation cycle ISO
Inferred from Sequence Orthology
more info
 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
glutamate metabolic process ISO
Inferred from Sequence Orthology
more info
 
glutamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
nitrogen compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon terminus ISO
Inferred from Sequence Orthology
more info
 
cell body IDA
Inferred from Direct Assay
more info
PubMed 
cell projection ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
glial cell projection IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
myelin sheath ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
glutamine synthetase
Names
glutamate decarboxylase
glutamate-ammonia ligase (glutamine synthase)
NP_032157.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008131.4NP_032157.2  glutamine synthetase

    See identical proteins and their annotated locations for NP_032157.2

    Status: VALIDATED

    Source sequence(s)
    AC099702, AK159106, BE946110
    Consensus CDS
    CCDS15381.1
    UniProtKB/Swiss-Prot
    P15105
    Related
    ENSMUSP00000083375, OTTMUSP00000017702, ENSMUST00000086199, OTTMUST00000039662
    Conserved Domains (3) summary
    PLN02284
    Location:22362
    PLN02284; glutamine synthetase
    pfam00120
    Location:110359
    Gln-synt_C; Glutamine synthetase, catalytic domain
    pfam03951
    Location:24104
    Gln-synt_N; Glutamine synthetase, beta-Grasp domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    153899929..153909723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    156333049..156342895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)