CSPG4 chondroitin sulfate proteoglycan 4 [Homo sapiens] - Gene

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Summary

Official Symbol: CSPG4provided by HGNC
Official Full Name: chondroitin sulfate proteoglycan 4provided by HGNC
Primary source: HGNC:2466
See related: Ensembl:ENSG00000173546; HPRD:03105; MIM:601172; Vega:OTTHUMG00000142836
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
Summary: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 15q24.2

Sequence :: Chromosome: 15; NC_000015.9 (75966663..76005189, complement)

See CSPG4 in Epigenomics, MapViewer

Chromosome 15 - NC_000015.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings define the CSPG4-specific fully human scFv-FcC21 antibody as a candidate therapeutic agent to target the many types of tumors that express CSPG4.
Title: Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG4.
High NG2 expression is associated with glioblastoma.
Title: NG2 expression in glioblastoma identifies an actively proliferating population with an aggressive molecular signature.
Functional and clinical relevance of chondroitin sulfate proteoglycan 4.
Title: Functional and clinical relevance of chondroitin sulfate proteoglycan 4.
In regions of spinal cord neurodegeneration of amyotrophic lateral sclerosis model mice, NG2-positive cells exhibit enhanced proliferation and accelerated differentiation into oligodendrocytes but remained committed to the oligodendrocyte lineage.
Title: NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration.
Cells that express NG2 proteoglycan act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord.
Title: NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease.
Results showed the expression of MCSP and PRAME in conjunctival melanoma and benign conjunctival nevi and showed that MCSP and PRAME were differentially expressed in both and can help to differentiate the lesions diagnostically.
Title: Expression of MCSP and PRAME in conjunctival melanoma.
Staining intensity of HMW-MAA in acral lentiginous melanoma lesions was weaker than in superficial spreading melanoma where it was found to be higher than previously reported.
Title: The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma.
in squamous cell carcinoma of head and neck and in basal breast carcinoma, CSPG4 is expressed by cancer stem cells
Title: CSPG4 in cancer: multiple roles.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP
Title: Human skin aging is associated with reduced expression of the stem cell markers beta1 integrin and MCSP.

Submit: New GeneRIF Correction See all (33)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q6UVK1	Activating transcription factor 7 interacting protein	ATF7IP	HPRD	PubMed
Q6UVK1	P56945	BCAR1	HPRD	PubMed
Q6UVK1	P02745	C1QA	HPRD	PubMed
Q6UVK1	P60953	CDC42	HPRD	PubMed
Q6UVK1	Q9Y3R0	GRIP1	HPRD	PubMed
Q6UVK1	Q9C0E4	GRIP2	HPRD	PubMed
Q6UVK1	O75970	MPDZ	HPRD	PubMed
Q6UVK1	Q05397	PTK2	HPRD	PubMed
Q6UVK1	Q07912	TNK2	HPRD	PubMed
BioGRID:107846	BioGRID:107433	CDC42	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107846	BioGRID:116995	GRIP1	BioGRID	PubMed	Two-hybrid
BioGRID:107846	BioGRID:123330	GRIP2	BioGRID	PubMed	Two-hybrid
BioGRID:107846	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
collagen binding	IEA Inferred from Electronic Annotation more info
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
neuron fate commitment	IEA Inferred from Electronic Annotation more info
neuron remodeling	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
apical plasma membrane	IEA Inferred from Electronic Annotation more info
cell projection	IEA Inferred from Electronic Annotation more info
cell surface	TAS Traceable Author Statement more info	PubMed
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
intracellular	IDA Inferred from Direct Assay more info	PubMed
lamellipodium membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: chondroitin sulfate proteoglycan 4

Names: chondroitin sulfate proteoglycan 4; chondroitin sulfate proteoglycan NG2; melanoma chondroitin sulfate proteoglycan; melanoma-associated chondroitin sulfate proteoglycan; chondroitin sulfate proteoglycan 4 (melanoma-associated)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001897.4 → NP_001888.2 chondroitin sulfate proteoglycan 4 precursor

Status: REVIEWED

Source sequence(s)

AY359468, BP363063, BQ679485, CA428796, CA438367, X96753

Consensus CDS

CCDS10284.1

UniProtKB/Swiss-Prot

Q6UVK1

Related

ENSP00000312506, OTTHUMP00000183520, ENST00000308508, OTTHUMT00000286472

Conserved Domains (1) summary

cd00110
Location:203 – 361
Blast Score: 220

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000015.9 Reference GRCh37.p5 Primary Assembly

Range

75966663..76005189, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000147.1 Alternate HuRef

Range

52722948..52761468, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC105020.18 (1660..39792)	None
genomic	CH471136.2	EAW99239.1
		EAW99240.1
mRNA	AY359468.1	AAQ62842.1
mRNA	BC033194.1	None
mRNA	BC128110.1	AAI28111.1
mRNA	BP363063.1	None
mRNA	BQ679485.1	None
mRNA	CA428796.1	None
mRNA	CA438367.1	None
mRNA	CB044012.1	None
mRNA	X96753.1	CAA65529.1
other-genetic	BC172270.1	AAI72270.1
other-genetic	BC172576.1	AAI72576.1