Gli2 GLI-Kruppel family member GLI2 [Mus musculus] - Gene

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Summary

Official Symbol: Gli2provided by MGI
Official Full Name: GLI-Kruppel family member GLI2provided by MGI
Primary source: MGI:95728
See related: Ensembl:ENSMUSG00000048402; Vega:OTTMUSG00000034815
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AW546128

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Genomic context

Location :: 1 E2-E4; 1 63.0 cM

Sequence :: Chromosome: 1; NC_000067.6 (118834061..119053619, complement)

See Gli2 in Epigenomics, MapViewer

Chromosome 1 - NC_000067.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells
Title: Ascl1/Mash1 is a novel target of Gli2 during Gli2-induced neurogenesis in P19 EC cells.
Results suggest functions of Shh-Gli signaling in sexually dimorphic development during embryogenesis. Shh expressed in urethral plate epithelium regulates genital tubercle differentiation through Gli2 in mesenchyme. (Shh = sonic hedgehog protein)
Title: The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia.
CCL5 signaling induces GLI2 through a PI3K-AKT-IkappaBalpha-p65 pathway and requires GLI2 transcriptional activity to modulate IL-6 expression and Ig secretion in vitro and in vivo
Title: GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.
In fetal testes prior to Leydig cell differentiation, expression of Gli1 and Gli2 is abolished by Hedgehog inhibitor GANT61. At later stages, GANT61 inhibits Gli1 expression but has no effects on Gli2 expression and fetal Leydig cell appearance.
Title: Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells.
The proper balance between the Gli2 full-length activator and repressor is essential for Hh signaling.
Title: Increased proteolytic processing of full-length Gli2 transcription factor reduces the hedgehog pathway activity in vivo.
ciliary localization of Sufu is dependent on ciliary-localized Gli proteins, and is inhibited by PKA activation
Title: Coordinated translocation of mammalian Gli proteins and suppressor of fused to the primary cilium.
Pkd1 and Kif3a counterbalance the regulation of osteogenesis and adipogenesis through differential regulation of Runx2 and PPARgamma by Gli2
Title: Kif3a deficiency reverses the skeletal abnormalities in Pkd1 deficient mice by restoring the balance between osteogenesis and adipogenesis.
The hedgehog signaling pathway at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA.
Title: A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.
Gli2, which encodes a major Gli activator, is required for proliferation of specific groups of pituitary progenitors but not for initial dorsoventral patterning.
Title: Direct and indirect requirements of Shh/Gli signaling in early pituitary development.
Pias1-dependent SUMOylation influences Gli protein activity
Title: SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors.

Submit: New GeneRIF Correction See all (48)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (2) 1 citation
Targeted (Reporter) (2) 1 citation
Targeted (knock-in) (9) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:199943	BioGRID:198403	Btrc	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:199943	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:199943	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleic acid binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
anatomical structure development	IGI Inferred from Genetic Interaction more info	PubMed
anatomical structure development	IMP Inferred from Mutant Phenotype more info	PubMed
anatomical structure formation involved in morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
branching morphogenesis of a tube	IMP Inferred from Mutant Phenotype more info	PubMed
cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
cell proliferation	ISO Inferred from Sequence Orthology more info
cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
cerebellar cortex morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
cerebellar cortex morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal/ventral neural tube patterning	IDA Inferred from Direct Assay more info	PubMed
dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
embryonic digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
epidermal cell differentiation	ISO Inferred from Sequence Orthology more info
floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
head development	IMP Inferred from Mutant Phenotype more info	PubMed
heart development	IGI Inferred from Genetic Interaction more info	PubMed
hindbrain development	IGI Inferred from Genetic Interaction more info	PubMed
hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
hindgut morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
hindgut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
kidney development	IGI Inferred from Genetic Interaction more info	PubMed
lung development	IGI Inferred from Genetic Interaction more info	PubMed
lung development	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland duct morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
neural tube development	IMP Inferred from Mutant Phenotype more info	PubMed
neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
notochord regression	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
osteoblast development	IDA Inferred from Direct Assay more info	PubMed
osteoblast development	IMP Inferred from Mutant Phenotype more info	PubMed
osteoblast differentiation	ISO Inferred from Sequence Orthology more info
pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
pattern specification process	IMP Inferred from Mutant Phenotype more info	PubMed
pituitary gland development	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
prostatic bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
proximal/distal pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
smoothened signaling pathway involved in dorsal/ventral neural tube patterning	IGI Inferred from Genetic Interaction more info	PubMed
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
smoothened signaling pathway involved in spinal cord motor neuron cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
smoothened signaling pathway involved in ventral spinal cord interneuron specification	IGI Inferred from Genetic Interaction more info	PubMed
spinal cord dorsal/ventral patterning	IGI Inferred from Genetic Interaction more info	PubMed
spinal cord dorsal/ventral patterning	IMP Inferred from Mutant Phenotype more info	PubMed
spinal cord ventral commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
tube development	IGI Inferred from Genetic Interaction more info	PubMed
ventral midline development	IGI Inferred from Genetic Interaction more info	PubMed
ventral midline development	IMP Inferred from Mutant Phenotype more info	PubMed
ventral spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cilium	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
membrane fraction	IDA Inferred from Direct Assay more info	PubMed
motile primary cilium	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: zinc finger protein GLI2

Names: zinc finger protein GLI2; Tax helper protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081125.1 → NP_001074594.1 zinc finger protein GLI2

Status: PROVISIONAL

Source sequence(s)

AC109271, AC122287, AC132589

Consensus CDS

CCDS35692.1

UniProtKB/Swiss-Prot

Q0VGT2

Related

ENSMUSP00000054837, OTTMUSP00000048224, ENSMUST00000062483, OTTMUST00000088493

Conserved Domains (2) summary

pfam09606
Location:1161 – 1398
Blast Score: 93

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13465
Location:469 – 496
Blast Score: 101

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000067.6 Reference GRCm38 C57BL/6J

Range

118834061..119053619, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000023.1 Alternate Mm_Celera

Range

121494112..121713823, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC109271.10 (173577..207697)	None
genomic	AC122287.4 (38550..150460)	None
genomic	AC132589.4 (63589..63906)	None
mRNA	AK051858.1	BAC34789.1	C57BL/6J
mRNA	AK078489.1	None	C57BL/6J
mRNA	AM261668.1	CAK12555.1	C57BL/6J
mRNA	AM261669.1	CAK12556.1	C57BL/6J
mRNA	AM261670.1	CAK12557.1	C57BL/6J
mRNA	AM262741.1	CAK18609.1	C57BL/6J
mRNA	AM262742.1	CAK18603.1	C57BL/6J
mRNA	AM262743.1	CAK18604.1	C57BL/6J
mRNA	AM262744.1	CAK18605.1	C57BL/6J
mRNA	BC031171.1	AAH31171.1	FVB/N
mRNA	BC082604.1	AAH82604.1	C57BL/6
mRNA	BC085190.1	AAH85190.1	C57BL/6
mRNA	X99104.1	None	C57BL/6

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q0VGT2.2	GenPept	UniProtKB/Swiss-Prot:Q0VGT2
Q0VGV1	GenPept	UniProtKB/TrEMBL:Q0VGV1
Q8BKI7	GenPept	UniProtKB/TrEMBL:Q8BKI7
Q8K0K3	GenPept	UniProtKB/TrEMBL:Q8K0K3