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    VCAN versican [ Homo sapiens (human) ]

    Gene ID: 1462, updated on 11-May-2013
    Official Symbol
    VCANprovided by HGNC
    Official Full Name
    versicanprovided by HGNC
    Primary source
    HGNC:2464
    See related
    Ensembl:ENSG00000038427; HPRD:00340; MIM:118661; Vega:OTTHUMG00000131321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WGN; ERVR; GHAP; PG-M; WGN1; CSPG2
    Summary
    This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Location :
    5q14.3
    Sequence :
    Chromosome: 5; NC_000005.9 (82767493..82878122)
    See VCAN in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 4 Neighboring gene ribosomal protein L13 pseudogene 9 Neighboring gene coenzyme Q10 homolog B pseudogene 2 Neighboring gene hyaluronan and proteoglycan link protein 1 Neighboring gene ribosomal protein L13a pseudogene 14

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Wagner syndrome

    Summary from GeneReviews: VCAN-Related Vitreoretinopathy Go to GeneReviews

    Disease Characteristics
    VCAN-related vitreoretinopathy, which includes Wagner syndrome and erosive vitreoretinopathy (ERVR), is characterized by "optically empty vitreous" on slit-lamp examination and avascular vitreous strands and veils, mild or occasionally moderate to severe myopia, presenile cataract, night blindness of variable degree associated with progressive chorioretinal atrophy, retinal traction and retinal detachment at advanced stages of the disease, and reduced visual acuity. Optic nerve inversion has also been described. Systemic abnormalities are not observed. The first signs usually become apparent during early adolescence, but onset can be as early as age two years.
    Diagnosis Testing
    The clinical diagnosis of VCAN-related vitreoretinopathy is established based on typical clinical findings and a family history consistent with autosomal dominant inheritance. VCAN (previously known as CSPG2) is the only gene in which mutations are known to cause Wagner syndrome and ERVR. Molecular genetic testing is available on a clinical basis.
    Genetic Counseling
    VCAN-related vitreoretinopathy is inherited in an autosomal dominant manner. Most individuals diagnosed with VCAN-related vitreoretinopathy have an affected parent. Each child of an affected individual has a 50% chance of inheriting the mutation. Prenatal testing for families with a known disease-causing mutation is available.
    References
    Products Interactant Other Gene Complex Source Pubs Description
    P13611 Q9UHI8 ADAMTS1    HPRD  PubMed  
    P13611 P13500 CCL2    HPRD  PubMed  
    P13611 P78556 CCL20    HPRD  PubMed  
    P13611 O00585 CCL21    HPRD  PubMed  
    P13611 P13501 CCL5    HPRD  PubMed  
    P13611 P80075 CCL8    HPRD  PubMed  
    P13611 P16070 CD44    HPRD  PubMed  
    P13611 P02778 CXCL10    HPRD  PubMed  
    P13611 P23142 FBLN1    HPRD  PubMed  
    P13611 P98095 FBLN2    HPRD  PubMed  
    P13611 P35555 FBN1    HPRD  PubMed  
    P13611 P10915 HAPLN1    HPRD  PubMed  
    P13611 P13612 ITGA4    HPRD  PubMed  
    P13611 P05556 ITGB1    HPRD  PubMed  
    P13611 P14555 PLA2G2A    HPRD  PubMed  
    P13611 P16109 SELP    HPRD  PubMed  
    P13611 Q14242 SELPLG    HPRD  PubMed  
    P13611 Q92752 TNR    HPRD  PubMed  
    P13611 P13611 VCAN    HPRD  PubMed  
    P13611 P47992 XCL1    HPRD  PubMed  
    BioGRID:107844 BioGRID:106684 ACAN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107844 BioGRID:112251 CCL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112267 CCL20    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112269 CCL21    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112255 CCL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112258 CCL8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:107398 CD44    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112288 CXCL12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:109094 CXCR3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:108493 FBLN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:108494 FBN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:107794 HAPLN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107844 BioGRID:111219 PF4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112302 SELL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112303 SELP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    • A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystem (from REACTOME)
      A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystemThe biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The ...
    • CS/DS degradation, organism-specific biosystem (from REACTOME)
      CS/DS degradation, organism-specific biosystemLysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of chondroitin sulfate and dermatan su...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Chondroitin sulfate biosynthesis, organism-specific biosystem (from REACTOME)
      Chondroitin sulfate biosynthesis, organism-specific biosystemChondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying ...
    • Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystem (from REACTOME)
      Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystemChondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-a...
    • Dermatan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
      Dermatan sulfate biosynthesis, organism-specific biosystemDermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
      Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
    • Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystem (from REACTOME)
      Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystemThe acronym HS-GAG is used to describe both heparin and heparan sulfate. HS-GAG is a member of the glycosaminoglycan family and consists of a variably sulfated repeating disaccharide unit, the most ...
    • MPS I - Hurler syndrome, organism-specific biosystem (from REACTOME)
      MPS I - Hurler syndrome, organism-specific biosystemMucopolysaccharidosis type I (MPS I, Hurler syndrome, Hurler's disease, gargoylism, Scheie, Hirler-Scheie syndrome; MIM:607014, 607015 and 607016) is an autosomal recessive genetic disorder where th...
    • MPS II - Hunter syndrome, organism-specific biosystem (from REACTOME)
      MPS II - Hunter syndrome, organism-specific biosystemMucopolysaccharidosis II (MPS II, Hunter syndrome, MIM:309900) is an X-linked, recessive genetic disorder which therefore primarily affects males. MPS II was first described in 1917, by Major Charles...
    • MPS IIIA - Sanfilippo syndrome A, organism-specific biosystem (from REACTOME)
      MPS IIIA - Sanfilippo syndrome A, organism-specific biosystemMucopolysaccharidosis III (MPS III, Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis IIIA (M...
    • MPS IIIB - Sanfilippo syndrome B, organism-specific biosystem (from REACTOME)
      MPS IIIB - Sanfilippo syndrome B, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). MPS IIIB (Mucopolysaccharidosis type II...
    • MPS IIIC - Sanfilippo syndrome C, organism-specific biosystem (from REACTOME)
      MPS IIIC - Sanfilippo syndrome C, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). Mucopolysaccharidosis type IIIC (MPS II...
    • MPS IIID - Sanfilippo syndrome D, organism-specific biosystem (from REACTOME)
      MPS IIID - Sanfilippo syndrome D, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis type IIID (MPS I...
    • MPS IV - Morquio syndrome A, organism-specific biosystem (from REACTOME)
      MPS IV - Morquio syndrome A, organism-specific biosystemMucopolysaccharidosis IV A (MPS IVA, MPS4A, Morquio's syndrome, Morquio's; MIM:253000) is a rare, autosomal recessive mucopolysaccharide storage disease, first described simultaneously in 1929 by L M...
    • MPS IV - Morquio syndrome B, organism-specific biosystem (from REACTOME)
      MPS IV - Morquio syndrome B, organism-specific biosystemDefects in beta-galactosidase (GLB1; MIM:611458) can result in GM1 gangliosidosis (GM1; MIM:230500) (Nishimoto et al. 1991) (not described here), with several phenotypes indicating mental deteriorati...
    • MPS IX - Natowicz syndrome, organism-specific biosystem (from REACTOME)
      MPS IX - Natowicz syndrome, organism-specific biosystemMucopolysaccharidosis type IX (MPS IX, Natowicz syndrome, Hyaluronidase deficiency, MIM:601492) is a rare lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum re...
    • MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystem (from REACTOME)
      MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystemMucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome, polydystrophic dwarfism; MIM:253200) is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (AR...
    • MPS VII - Sly syndrome, organism-specific biosystem (from REACTOME)
      MPS VII - Sly syndrome, organism-specific biosystemMucopolysaccharidosis type VII (MPS VII, Sly syndrome, beta-glucuronidase deficiency; MIM:253220) is an autosomal recessive lysosomal storage disease characterized by a deficiency of the enzyme beta-...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Mucopolysaccharidoses, organism-specific biosystem (from REACTOME)
      Mucopolysaccharidoses, organism-specific biosystemThe mucopolysaccharidoses (MPS) are a group of rare, inherited lysosomal storage disorders caused by deficiencies of enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs, originall...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

    Markers

    Homology

    Clone Names

    • DKFZp686K06110

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycosaminoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell recognition TAS
    Traceable Author Statement
    more info
    PubMed 
    chondroitin sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    chondroitin sulfate catabolic process TAS
    Traceable Author Statement
    more info
     
    chondroitin sulfate metabolic process TAS
    Traceable Author Statement
    more info
     
    dermatan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    glial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycosaminoglycan metabolic process TAS
    Traceable Author Statement
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development TAS
    Traceable Author Statement
    more info
    PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi lumen TAS
    Traceable Author Statement
    more info
     
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
     
    lysosomal lumen TAS
    Traceable Author Statement
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    versican core protein
    Names
    versican core protein
    versican proteoglycan
    large fibroblast proteoglycan
    glial hyaluronate-binding protein
    chondroitin sulfate proteoglycan 2
    chondroitin sulfate proteoglycan core protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012682.1 RefSeqGene

      Range
      4964..115593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126336.2NP_001119808.1  versican core protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as PG-M(V3), omits two coding exons, compared to variant 1. This results in a shorter protein (isoform 2) with no chondroitin sulfate attachment domain.
      Source sequence(s)
      AC026696, BC050524, D32039, DA361670, DT217515
      Consensus CDS
      CCDS47242.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q86W61
      Conserved Domains (7) summary
      cd00054
      Location:386422
      Blast Score: 118
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 413
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 432
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 596
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:555611
      Blast Score: 130
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07686
      Location:29147
      Blast Score: 153
      V-set; Immunoglobulin V-set domain
      cl02432
      Location:428551
      Blast Score: 617
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    2. NM_001164097.1NP_001157569.1  versican core protein isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as PG-M(V1), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA320958, AC026696, BX641036, DA361670, X15998
      Consensus CDS
      CCDS54876.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q6MZK8
      Related
      ENSP00000340062, ENST00000343200
      Conserved Domains (7) summary
      cd00054
      Location:21402176
      Blast Score: 144
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 444
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 458
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 567
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:23092365
      Blast Score: 140
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21822305
      Blast Score: 654
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 150
      V-set; Immunoglobulin V-set domain
    3. NM_001164098.1NP_001157570.1  versican core protein isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as PG-M(V2), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AA320958, AC026696, DA361670, U26555
      Consensus CDS
      CCDS54875.1
      UniProtKB/Swiss-Prot
      P13611
      Related
      ENSP00000342768, ENST00000342785
      Conserved Domains (7) summary
      cd00054
      Location:13731409
      Blast Score: 141
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 443
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 457
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 565
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:15421598
      Blast Score: 138
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:14151538
      Blast Score: 657
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 150
      V-set; Immunoglobulin V-set domain
    4. NM_004385.4NP_004376.2  versican core protein isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as PG-M(V0), encodes the longest isoform (1).
      Source sequence(s)
      AB209491, AC026696, DA361670, DT217515, U16306
      Consensus CDS
      CCDS4060.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q59FG9
      Related
      ENSP00000265077, OTTHUMP00000161998, ENST00000265077, OTTHUMT00000254092
      Conserved Domains (7) summary
      cd00054
      Location:31273163
      Blast Score: 151
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 451
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 463
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 560
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:32963352
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:31693292
      Blast Score: 664
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 149
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p10 Primary Assembly

      Range
      82767493..82878122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      77975785..78086373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018916.1 Alternate CHM1_1.0

      Range
      83059902..83170526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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