VCAN versican [Homo sapiens (human)] - Gene

Summary

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Official Symbol: VCANprovided by HGNC
Official Full Name: versicanprovided by HGNC
Primary source: HGNC:2464
See related: Ensembl:ENSG00000038427; HPRD:00340; MIM:118661; Vega:OTTHUMG00000131321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WGN; ERVR; GHAP; PG-M; WGN1; CSPG2
Summary: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Genomic context

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Location :: 5q14.3

Sequence :: Chromosome: 5; NC_000005.9 (82767493..82878122)

See VCAN in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Wnt/beta-catenin signal transducting system regulates dermal papilla cell aggregative growth through modifying versican expression by means of acting on the versican gene upstream promoter.
Title: Versican gene: regulation by the β-catenin signaling pathway plays a significant role in dermal papilla cell aggregative growth.
these results demonstrate that versican V0 and V1 isoforms play important roles in HCC development and that versican mRNAs compete with endogenous RNAs in regulating miRNA functions.
Title: Versican 3'-untranslated region (3'-UTR) functions as a ceRNA in inducing the development of hepatocellular carcinoma by regulating miRNA activity.
Mesenchymal cells derived from keloid lesion (KL) cells exhibit above-normal versican production.
Title: An ex vivo model employing keloid-derived cell-seeded collagen sponges for therapy development.
the glioblastoma cell line U87 stably transfected with versican isoform V2 formed tumors containing extensive vasculature
Title: Versican V2 isoform enhances angiogenesis by regulating endothelial cell activities and fibronectin expression.
renal versican expression was significantly upregulated as compared to corresponding controls. These data show for the first time an association of renal versican isoform V0 and V1 expression with progressive renal disease.
Title: Increased renal versican expression is associated with progression of chronic kidney disease.
Studies indicate that E-cadherin and versican are involved in cancer epithelial-mesenchymal transitions and metastasis.
Title: Microenvironmental regulation of epithelial-mesenchymal transitions in cancer.
Tissue microarray analysis revealed that epithelial expression of versican had significant relations to lymph node metastasis and pathological stages of breast cancer
Title: Altered expression of sialylated glycoproteins in breast cancer using hydrazide chemistry and mass spectrometry.
E(2) treatment increases the amount of dermal HA and versican V2 via paracrine release of EGF, which may be implicated in the pro-proliferative and anti-inflammatory effects of E(2) during photoaging.
Title: Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes.
The major isoforms expressed by gastric carcinoma & gastric cell lines were V0 & V1. V1 was higher in gastric carcinoma. Abnormally expressed versican & its isoforms participate in the progress of gastric carcinoma triggered by IL-11.
Title: Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.
RhoGDI2 suppresses lung metastasis in mouse models by reducing the expression of isoforms V1 and V3 of the proteoglycan versican, which is require for lung metastasis. High versican levels portended poor prognosis in patients with bladder cancer.
Title: RhoGDI2 suppresses lung metastasis in mice by reducing tumor versican expression and macrophage infiltration.

Submit: New GeneRIF Correction See all (79)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

VCAN-related vitreoretinopathy, which includes Wagner syndrome and erosive vitreoretinopathy (ERVR), is characterized by "optically empty vitreous" on slit-lamp examination and avascular vitreous strands and veils, mild or occasionally moderate to severe myopia, presenile cataract, night blindness of variable degree associated with progressive chorioretinal atrophy, retinal traction and retinal detachment at advanced stages of the disease, and reduced visual acuity. Optic nerve inversion has also been described. Systemic abnormalities are not observed. The first signs usually become apparent during early adolescence, but onset can be as early as age two years.

Diagnosis Testing

The clinical diagnosis of VCAN-related vitreoretinopathy is established based on typical clinical findings and a family history consistent with autosomal dominant inheritance. VCAN (previously known as CSPG2) is the only gene in which mutations are known to cause Wagner syndrome and ERVR. Molecular genetic testing is available on a clinical basis.

Genetic Counseling

VCAN-related vitreoretinopathy is inherited in an autosomal dominant manner. Most individuals diagnosed with VCAN-related vitreoretinopathy have an affected parent. Each child of an affected individual has a 50% chance of inheriting the mutation. Prenatal testing for families with a known disease-causing mutation is available.

References

PMID: 20301747

NHGRI GWAS Catalog

Genome-wide association study of major recurrent depression in the U.K. population.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P13611	Q9UHI8	ADAMTS1	HPRD	PubMed
P13611	P13500	CCL2	HPRD	PubMed
P13611	P78556	CCL20	HPRD	PubMed
P13611	O00585	CCL21	HPRD	PubMed
P13611	P13501	CCL5	HPRD	PubMed
P13611	P80075	CCL8	HPRD	PubMed
P13611	P16070	CD44	HPRD	PubMed
P13611	P02778	CXCL10	HPRD	PubMed
P13611	P23142	FBLN1	HPRD	PubMed
P13611	P98095	FBLN2	HPRD	PubMed
P13611	P35555	FBN1	HPRD	PubMed
P13611	P10915	HAPLN1	HPRD	PubMed
P13611	P13612	ITGA4	HPRD	PubMed
P13611	P05556	ITGB1	HPRD	PubMed
P13611	P14555	PLA2G2A	HPRD	PubMed
P13611	P16109	SELP	HPRD	PubMed
P13611	Q14242	SELPLG	HPRD	PubMed
P13611	Q92752	TNR	HPRD	PubMed
P13611	P13611	VCAN	HPRD	PubMed
P13611	P47992	XCL1	HPRD	PubMed
BioGRID:107844	BioGRID:106684	ACAN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107844	BioGRID:112251	CCL2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112267	CCL20	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112269	CCL21	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112255	CCL5	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112258	CCL8	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:107398	CD44	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112288	CXCL12	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:109094	CXCR3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:108493	FBLN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:108494	FBN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:107794	HAPLN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107844	BioGRID:111219	PF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112302	SELL	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112303	SELP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystem (from REACTOME)
A tetrasaccharide linker sequence is required for GAG synthesis, organism-specific biosystemThe biosynthesis of dermatan sulfate/chondroitin sulfate and heparin/heparan sulfate glycosaminoglycans (GAGs) starts with the formation of a tetrasaccharide linker sequence to the core protein. The ...
CS/DS degradation, organism-specific biosystem (from REACTOME)
CS/DS degradation, organism-specific biosystemLysosomal degradation of glycoproteins is part of the cellular homeostasis of glycosylation (Winchester 2005). The steps outlined below describe the degradation of chondroitin sulfate and dermatan su...
Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
Chondroitin sulfate biosynthesis, organism-specific biosystem (from REACTOME)
Chondroitin sulfate biosynthesis, organism-specific biosystemChondroitin sulfate (CS) glycosaminoglycan consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA). GalNAc residues are sulfated to varying ...
Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystem (from REACTOME)
Chondroitin sulfate/dermatan sulfate metabolism, organism-specific biosystemChondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-a...
Dermatan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
Dermatan sulfate biosynthesis, organism-specific biosystemDermatan sulfate (DS) consists of N-acetylgalactosamine (GalNAc) residues alternating in glycosidic linkages with glucuronic acid (GlcA) or iduronic acid (IdoA) residues. As with CS, GalNAc residues ...
Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
Direct p53 effectors, organism-specific biosystem
Direct p53 effectors
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystem (from REACTOME)
Heparan sulfate/heparin (HS-GAG) metabolism, organism-specific biosystemThe acronym HS-GAG is used to describe both heparin and heparan sulfate. HS-GAG is a member of the glycosaminoglycan family and consists of a variably sulfated repeating disaccharide unit, the most ...
MPS I - Hurler syndrome, organism-specific biosystem (from REACTOME)
MPS I - Hurler syndrome, organism-specific biosystemMucopolysaccharidosis type I (MPS I, Hurler syndrome, Hurler's disease, gargoylism, Scheie, Hirler-Scheie syndrome; MIM:607014, 607015 and 607016) is an autosomal recessive genetic disorder where th...
MPS II - Hunter syndrome, organism-specific biosystem (from REACTOME)
MPS II - Hunter syndrome, organism-specific biosystemMucopolysaccharidosis II (MPS II, Hunter syndrome, MIM:309900) is an X-linked, recessive genetic disorder which therefore primarily affects males. MPS II was first described in 1917, by Major Charles...
MPS IIIA - Sanfilippo syndrome A, organism-specific biosystem (from REACTOME)
MPS IIIA - Sanfilippo syndrome A, organism-specific biosystemMucopolysaccharidosis III (MPS III, Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis IIIA (M...
MPS IIIB - Sanfilippo syndrome B, organism-specific biosystem (from REACTOME)
MPS IIIB - Sanfilippo syndrome B, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). MPS IIIB (Mucopolysaccharidosis type II...
MPS IIIC - Sanfilippo syndrome C, organism-specific biosystem (from REACTOME)
MPS IIIC - Sanfilippo syndrome C, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). Mucopolysaccharidosis type IIIC (MPS II...
MPS IIID - Sanfilippo syndrome D, organism-specific biosystem (from REACTOME)
MPS IIID - Sanfilippo syndrome D, organism-specific biosystemMucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837-838, 1963, no reference). Mucopolysaccharidosis type IIID (MPS I...
MPS IV - Morquio syndrome A, organism-specific biosystem (from REACTOME)
MPS IV - Morquio syndrome A, organism-specific biosystemMucopolysaccharidosis IV A (MPS IVA, MPS4A, Morquio's syndrome, Morquio's; MIM:253000) is a rare, autosomal recessive mucopolysaccharide storage disease, first described simultaneously in 1929 by L M...
MPS IV - Morquio syndrome B, organism-specific biosystem (from REACTOME)
MPS IV - Morquio syndrome B, organism-specific biosystemDefects in beta-galactosidase (GLB1; MIM:611458) can result in GM1 gangliosidosis (GM1; MIM:230500) (Nishimoto et al. 1991) (not described here), with several phenotypes indicating mental deteriorati...
MPS IX - Natowicz syndrome, organism-specific biosystem (from REACTOME)
MPS IX - Natowicz syndrome, organism-specific biosystemMucopolysaccharidosis type IX (MPS IX, Natowicz syndrome, Hyaluronidase deficiency, MIM:601492) is a rare lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum re...
MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystem (from REACTOME)
MPS VI - Maroteaux-Lamy syndrome, organism-specific biosystemMucopolysaccharidosis type VI (MPS VI, Maroteaux-Lamy syndrome, polydystrophic dwarfism; MIM:253200) is an autosomal recessive lysosomal storage disorder caused by a deficiency in arylsulfatase B (AR...
MPS VII - Sly syndrome, organism-specific biosystem (from REACTOME)
MPS VII - Sly syndrome, organism-specific biosystemMucopolysaccharidosis type VII (MPS VII, Sly syndrome, beta-glucuronidase deficiency; MIM:253220) is an autosomal recessive lysosomal storage disease characterized by a deficiency of the enzyme beta-...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
Mucopolysaccharidoses, organism-specific biosystem (from REACTOME)
Mucopolysaccharidoses, organism-specific biosystemThe mucopolysaccharidoses (MPS) are a group of rare, inherited lysosomal storage disorders caused by deficiencies of enzymes catalyzing the stepwise degradation of glycosaminoglycans (GAGs, originall...
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...

General gene information

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Markers

RH17573 (e-PCR)
- UniSTS:22275

RH45290 (e-PCR)
- UniSTS:6404

SHGC-82303 (e-PCR)
- UniSTS:104244

L28255 (e-PCR)
- UniSTS:80695

RH69411 (e-PCR)
- UniSTS:33638

CSPG2 (e-PCR)
- UniSTS:504954

RH35859 (e-PCR)
- UniSTS:1679

SHGC-68433 (e-PCR)
- UniSTS:95423

SHGC-148767 (e-PCR)
- UniSTS:176596

STS-W72577 (e-PCR)
- UniSTS:60398

Genotypes

See VCAN SNP Geneview Report
See VCAN SNP Genotype Report
See VCAN SNP Variation Viewer Report

Homology

Homologs of the VCAN gene: The VCAN gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Clone Names

DKFZp686K06110

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
carbohydrate binding	IEA Inferred from Electronic Annotation more info
glycosaminoglycan binding	TAS Traceable Author Statement more info	PubMed
hyaluronic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
carbohydrate metabolic process	TAS Traceable Author Statement more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell recognition	TAS Traceable Author Statement more info	PubMed
chondroitin sulfate biosynthetic process	TAS Traceable Author Statement more info
chondroitin sulfate catabolic process	TAS Traceable Author Statement more info
chondroitin sulfate metabolic process	TAS Traceable Author Statement more info
dermatan sulfate biosynthetic process	TAS Traceable Author Statement more info
glial cell migration	IDA Inferred from Direct Assay more info	PubMed
glycosaminoglycan metabolic process	TAS Traceable Author Statement more info
heart development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
Golgi lumen	TAS Traceable Author Statement more info
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
colocalizes_with extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info
lysosomal lumen	TAS Traceable Author Statement more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: versican core protein

Names: versican core protein; versican proteoglycan; large fibroblast proteoglycan; glial hyaluronate-binding protein; chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012682.1 RefSeqGene

Range

4964..115593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001126336.2 → NP_001119808.1 versican core protein isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as PG-M(V3), omits two coding exons, compared to variant 1. This results in a shorter protein (isoform 2) with no chondroitin sulfate attachment domain.

Source sequence(s)

AC026696, BC050524, D32039, DA361670, DT217515

Consensus CDS

CCDS47242.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q86W61

Conserved Domains (7) summary

cd00054
Location:386 – 422
Blast Score: 118

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 413

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 432

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 596

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:555 – 611
Blast Score: 130

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam07686
Location:29 – 147
Blast Score: 153

V-set; Immunoglobulin V-set domain

cl02432
Location:428 – 551
Blast Score: 617

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_001164097.1 → NP_001157569.1 versican core protein isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as PG-M(V1), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AA320958, AC026696, BX641036, DA361670, X15998

Consensus CDS

CCDS54876.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q6MZK8

Related

ENSP00000340062, ENST00000343200

Conserved Domains (7) summary

cd00054
Location:2140 – 2176
Blast Score: 144

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 444

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 458

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 567

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:2309 – 2365
Blast Score: 140

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:2182 – 2305
Blast Score: 654

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 150

V-set; Immunoglobulin V-set domain
NM_001164098.1 → NP_001157570.1 versican core protein isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as PG-M(V2), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AA320958, AC026696, DA361670, U26555

Consensus CDS

CCDS54875.1

UniProtKB/Swiss-Prot

P13611

Related

ENSP00000342768, ENST00000342785

Conserved Domains (7) summary

cd00054
Location:1373 – 1409
Blast Score: 141

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 443

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 457

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 565

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:1542 – 1598
Blast Score: 138

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:1415 – 1538
Blast Score: 657

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 150

V-set; Immunoglobulin V-set domain
NM_004385.4 → NP_004376.2 versican core protein isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as PG-M(V0), encodes the longest isoform (1).

Source sequence(s)

AB209491, AC026696, DA361670, DT217515, U16306

Consensus CDS

CCDS4060.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q59FG9

Related

ENSP00000265077, OTTHUMP00000161998, ENST00000265077, OTTHUMT00000254092

Conserved Domains (7) summary

cd00054
Location:3127 – 3163
Blast Score: 151

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 451

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 463

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 560

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:3296 – 3352
Blast Score: 142

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:3169 – 3292
Blast Score: 664

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 149

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

82767493..82878122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

77975785..78086373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

83059902..83170526

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01062084.1 (216654..327242)	None
genomic	AC016568.5	None
genomic	AC020921.6	None
genomic	AC026696.5 (28453..125561)	None
genomic	AMYH01015456.1 (8013..118637)	None
genomic	CH471084.1	EAW95904.1
		EAW95905.1
		EAW95906.1
		EAW95907.1
		EAW95908.1
		EAW95909.1
		EAW95910.1
		EAW95911.1
genomic	S52488.1	AAB24878.1
mRNA	AA320958.1	None
mRNA	AA426499.1	None
mRNA	AA478645.1	None
mRNA	AB209491.1	BAD92728.1
mRNA	AF084545.1	AAD48545.1
mRNA	AK296285.1	BAH12302.1
mRNA	AK299770.1	BAH13124.1
mRNA	AK307642.1	None
mRNA	BC050524.1	AAH50524.1
mRNA	BP332680.1	None
mRNA	BX641036.1	CAE46022.1
mRNA	CN312093.1	None
mRNA	D32039.1	BAA06801.1
mRNA	DA361670.1	None
mRNA	DB497892.1	None
mRNA	DT217515.1	None
mRNA	J02814.1	AAA36437.1
mRNA	U16306.1	AAA65018.1
mRNA	U26555.1	AAA67565.1
mRNA	X15998.1	CAA34128.1
other-genetic	BC172276.1	AAI72276.1