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    VCAN versican [ Homo sapiens ]

    Gene ID: 1462, updated on 11-May-2012

    Summary

    Official Symbol
    VCANprovided by HGNC
    Official Full Name
    versicanprovided by HGNC
    Primary source
    HGNC:2464
    See related
    Ensembl:ENSG00000038427; HPRD:00340; MIM:118661; Vega:OTTHUMG00000131321
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WGN; ERVR; GHAP; PG-M; WGN1; CSPG2; DKFZp686K06110
    Summary
    This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

    Genomic context

    Location :
    5q14.3
    Sequence :
    Chromosome: 5; NC_000005.9 (82767493..82878122)
    See VCAN in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 4 Neighboring gene ribosomal protein L13 pseudogene 9 Neighboring gene coenzyme Q10 homolog B (S. cerevisiae) pseudogene Neighboring gene hyaluronan and proteoglycan link protein 1 Neighboring gene ribosomal protein L13a pseudogene 14

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P13611 Q9UHI8 ADAMTS1    HPRD  PubMed  
    P13611 P13500 CCL2    HPRD  PubMed  
    P13611 P78556 CCL20    HPRD  PubMed  
    P13611 O00585 CCL21    HPRD  PubMed  
    P13611 P13501 CCL5    HPRD  PubMed  
    P13611 P80075 CCL8    HPRD  PubMed  
    P13611 P16070 CD44    HPRD  PubMed  
    P13611 P02778 CXCL10    HPRD  PubMed  
    P13611 P23142 FBLN1    HPRD  PubMed  
    P13611 P98095 FBLN2    HPRD  PubMed  
    P13611 P35555 FBN1    HPRD  PubMed  
    P13611 P10915 HAPLN1    HPRD  PubMed  
    P13611 P13612 ITGA4    HPRD  PubMed  
    P13611 P05556 ITGB1    HPRD  PubMed  
    P13611 P14555 PLA2G2A    HPRD  PubMed  
    P13611 P16109 SELP    HPRD  PubMed  
    P13611 Q14242 SELPLG    HPRD  PubMed  
    P13611 Q92752 TNR    HPRD  PubMed  
    P13611 P13611 VCAN    HPRD  PubMed  
    P13611 P47992 XCL1    HPRD  PubMed  
    BioGRID:107844 BioGRID:106684 ACAN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107844 BioGRID:112251 CCL2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112267 CCL20    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112269 CCL21    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112255 CCL5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112258 CCL8    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:107398 CD44    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112288 CXCL12    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:109094 CXCR3    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:108493 FBLN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:108494 FBN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:107794 HAPLN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107844 BioGRID:111219 PF4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112302 SELL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:112303 SELP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107844 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    glycosaminoglycan binding TAS
    Traceable Author Statement
    more info
    PubMed 
    hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell recognition TAS
    Traceable Author Statement
    more info
    PubMed 
    glial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organismal development TAS
    Traceable Author Statement
    more info
    PubMed 
    response to wounding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with extracellular matrix IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    versican core protein
    Names
    versican core protein
    versican proteoglycan
    large fibroblast proteoglycan
    glial hyaluronate-binding protein
    chondroitin sulfate proteoglycan 2
    chondroitin sulfate proteoglycan core protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012682.1 RefSeqGene

      Range
      4964..115593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126336.2NP_001119808.1  versican core protein isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as PG-M(V3), omits two coding exons, compared to variant 1. This results in a shorter protein (isoform 2) with no chondroitin sulfate attachment domain.
      Source sequence(s)
      AC026696, BC050524, D32039, DA361670, DT217515
      Consensus CDS
      CCDS47242.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q86W61
      Related
      ENSP00000421362, OTTHUMP00000222358, ENST00000502527, OTTHUMT00000369622
      Conserved Domains (7) summary
      cd00054
      Location:386422
      Blast Score: 118
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 413
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 432
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 596
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:555611
      Blast Score: 130
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam07686
      Location:29147
      Blast Score: 153
      V-set; Immunoglobulin V-set domain
      cl02432
      Location:428551
      Blast Score: 617
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    2. NM_001164097.1NP_001157569.1  versican core protein isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as PG-M(V1), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA320958, AC026696, BX641036, DA361670, X15998
      Consensus CDS
      CCDS54876.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q6MZK8
      Related
      ENSP00000340062, ENST00000343200
      Conserved Domains (7) summary
      cd00054
      Location:21402176
      Blast Score: 144
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 444
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 458
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 567
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:23092365
      Blast Score: 140
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:21822305
      Blast Score: 654
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 150
      V-set; Immunoglobulin V-set domain
    3. NM_001164098.1NP_001157570.1  versican core protein isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as PG-M(V2), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AA320958, AC026696, DA361670, U26555
      Consensus CDS
      CCDS54875.1
      UniProtKB/Swiss-Prot
      P13611
      Related
      ENSP00000342768, ENST00000342785
      Conserved Domains (7) summary
      cd00054
      Location:13731409
      Blast Score: 141
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 443
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 457
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 565
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:15421598
      Blast Score: 138
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:14151538
      Blast Score: 657
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 150
      V-set; Immunoglobulin V-set domain
    4. NM_004385.4NP_004376.2  versican core protein isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as PG-M(V0), encodes the longest isoform (1).
      Source sequence(s)
      AB209491, AC026696, DA361670, DT217515, U16306
      Consensus CDS
      CCDS4060.1
      UniProtKB/Swiss-Prot
      P13611
      UniProtKB/TrEMBL
      Q59FG9
      Related
      ENSP00000265077, OTTHUMP00000161998, ENST00000265077, OTTHUMT00000254092
      Conserved Domains (7) summary
      cd00054
      Location:31273163
      Blast Score: 151
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:150244
      Blast Score: 451
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:251346
      Blast Score: 463
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      cd05901
      Location:36151
      Blast Score: 560
      Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican
      cd00033
      Location:32963352
      Blast Score: 142
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd03588
      Location:31693292
      Blast Score: 664
      CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins
      pfam07686
      Location:29147
      Blast Score: 149
      V-set; Immunoglobulin V-set domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      82767493..82878122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      77975785..78086373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016568.5 None
    genomic AC020921.6 None
    genomic AC026696.5 (28452..125560) None
    genomic CH471084.1 EAW95904.1
      EAW95905.1
      EAW95906.1
      EAW95907.1
      EAW95908.1
      EAW95909.1
      EAW95910.1
      EAW95911.1
    genomic S52488.1 AAB24878.1
    mRNA AA320958.1 None
    mRNA AA426499.1 None
    mRNA AA478645.1 None
    mRNA AB209491.1 BAD92728.1
    mRNA AF084545.1 AAD48545.1
    mRNA AK296285.1 BAH12302.1
    mRNA AK299770.1 BAH13124.1
    mRNA AK307642.1 None
    mRNA BC050524.1 AAH50524.1
    mRNA BP332680.1 None
    mRNA BX641036.1 CAE46022.1
    mRNA CN312093.1 None
    mRNA D32039.1 BAA06801.1
    mRNA DA361670.1 None
    mRNA DB497892.1 None
    mRNA DT217515.1 None
    mRNA J02814.1 AAA36437.1
    mRNA U16306.1 AAA65018.1
    mRNA U26555.1 AAA67565.1
    mRNA X15998.1 CAA34128.1
    other-genetic BC172276.1 AAI72276.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13611.3 GenPept UniProtKB/Swiss-Prot:P13611
    Q59FG9 GenPept UniProtKB/TrEMBL:Q59FG9
    Q6MZK8 GenPept UniProtKB/TrEMBL:Q6MZK8
    Q86W61 GenPept UniProtKB/TrEMBL:Q86W61

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