VCAN versican [Homo sapiens] - Gene

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Summary

Official Symbol: VCANprovided by HGNC
Official Full Name: versicanprovided by HGNC
Primary source: HGNC:2464
See related: Ensembl:ENSG00000038427; HPRD:00340; MIM:118661; Vega:OTTHUMG00000131321
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WGN; ERVR; GHAP; PG-M; WGN1; CSPG2; DKFZp686K06110
Summary: This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

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Genomic context

Location :: 5q14.3

Sequence :: Chromosome: 5; NC_000005.9 (82767493..82878122)

See VCAN in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Title: Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Versican G3 domain enhanced tumor cell resistance to apoptosis when cultured in serum free medium, Doxorubicin, or Epirubicin by up-regulating pERK and GSK-3beta (S9P).
Title: Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
Versican demonstrated distinctive localization relative to nodules within calcified aortic valves.
Title: Differential proteoglycan and hyaluronan distribution in calcified aortic valves.
Data show that elevated levels of versican were correlated with higher tumor grade and invasiveness in carcinomas with MD and MAMCs, whereas increased amounts of decorin were associated with in situ carcinomas in MAMCs.
Title: Versican but not decorin accumulation is related to malignancy in mammographically detected high density and malignant-appearing microcalcifications in non-palpable breast carcinomas.
a physiological function of ADAMTS5 in dermal fibroblasts is to maintain optimal versican content and PCM volume by continually trimming versican in hyaluronan-versican aggregates.
Title: Pericellular versican regulates the fibroblast-myofibroblast transition: a role for ADAMTS5 protease-mediated proteolysis.
A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features.
Title: A new VCAN/versican splice acceptor site mutation in a French Wagner family associated with vascular and inflammatory ocular features.
Versican appears to be a central component of the outflow resistance, where it may organize GAGs and other ECM components to facilitate and control open flow channels in the trabecular meshwork.
Title: Segmental versican expression in the trabecular meshwork and involvement in outflow facility.
High versican is associated with metastatic gastrointestinal stromal tumors.
Title: Microarray analysis identifies versican and CD9 as potent prognostic markers in gastric gastrointestinal stromal tumors.
Suggest that versican expression in in situ breast lesions may define different subtypes of intraductal carcinomas.
Title: Expression of proteoglycan versican in in situ breast lesions: relations between stromal changes, histotype, and invasion.
both versican and CD44 play an important role regulating the behavior of malignant melanoma cells
Title: Role of versican V0/V1 and CD44 in the regulation of human melanoma cell behavior.

Submit: New GeneRIF Correction See all (66)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of major recurrent depression in the U.K. population.

Products	Interactant	Other Gene	Source	Pubs	Description
P13611	Q9UHI8	ADAMTS1	HPRD	PubMed
P13611	P13500	CCL2	HPRD	PubMed
P13611	P78556	CCL20	HPRD	PubMed
P13611	O00585	CCL21	HPRD	PubMed
P13611	P13501	CCL5	HPRD	PubMed
P13611	P80075	CCL8	HPRD	PubMed
P13611	P16070	CD44	HPRD	PubMed
P13611	P02778	CXCL10	HPRD	PubMed
P13611	P23142	FBLN1	HPRD	PubMed
P13611	P98095	FBLN2	HPRD	PubMed
P13611	P35555	FBN1	HPRD	PubMed
P13611	P10915	HAPLN1	HPRD	PubMed
P13611	P13612	ITGA4	HPRD	PubMed
P13611	P05556	ITGB1	HPRD	PubMed
P13611	P14555	PLA2G2A	HPRD	PubMed
P13611	P16109	SELP	HPRD	PubMed
P13611	Q14242	SELPLG	HPRD	PubMed
P13611	Q92752	TNR	HPRD	PubMed
P13611	P13611	VCAN	HPRD	PubMed
P13611	P47992	XCL1	HPRD	PubMed
BioGRID:107844	BioGRID:106684	ACAN	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107844	BioGRID:112251	CCL2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112267	CCL20	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112269	CCL21	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112255	CCL5	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112258	CCL8	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:107398	CD44	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112288	CXCL12	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:109094	CXCR3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:108493	FBLN2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:108494	FBN1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:107794	HAPLN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107844	BioGRID:111219	PF4	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112302	SELL	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:112303	SELP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107844	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
glycosaminoglycan binding	TAS Traceable Author Statement more info	PubMed
hyaluronic acid binding	IEA Inferred from Electronic Annotation more info
sugar binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
axon regeneration	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell recognition	TAS Traceable Author Statement more info	PubMed
glial cell migration	IDA Inferred from Direct Assay more info	PubMed
heart development	IEA Inferred from Electronic Annotation more info
multicellular organismal development	TAS Traceable Author Statement more info	PubMed
response to wounding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with extracellular matrix	IDA Inferred from Direct Assay more info
colocalizes_with extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info
proteinaceous extracellular matrix	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: versican core protein

Names: versican core protein; versican proteoglycan; large fibroblast proteoglycan; glial hyaluronate-binding protein; chondroitin sulfate proteoglycan 2; chondroitin sulfate proteoglycan core protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012682.1 RefSeqGene

Range

4964..115593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001126336.2 → NP_001119808.1 versican core protein isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2), also known as PG-M(V3), omits two coding exons, compared to variant 1. This results in a shorter protein (isoform 2) with no chondroitin sulfate attachment domain.

Source sequence(s)

AC026696, BC050524, D32039, DA361670, DT217515

Consensus CDS

CCDS47242.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q86W61

Related

ENSP00000421362, OTTHUMP00000222358, ENST00000502527, OTTHUMT00000369622

Conserved Domains (7) summary

cd00054
Location:386 – 422
Blast Score: 118

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 413

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 432

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 596

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:555 – 611
Blast Score: 130

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

pfam07686
Location:29 – 147
Blast Score: 153

V-set; Immunoglobulin V-set domain

cl02432
Location:428 – 551
Blast Score: 617

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_001164097.1 → NP_001157569.1 versican core protein isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3), also known as PG-M(V1), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AA320958, AC026696, BX641036, DA361670, X15998

Consensus CDS

CCDS54876.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q6MZK8

Related

ENSP00000340062, ENST00000343200

Conserved Domains (7) summary

cd00054
Location:2140 – 2176
Blast Score: 144

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 444

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 458

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 567

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:2309 – 2365
Blast Score: 140

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:2182 – 2305
Blast Score: 654

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 150

V-set; Immunoglobulin V-set domain
NM_001164098.1 → NP_001157570.1 versican core protein isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4), also known as PG-M(V2), lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.

Source sequence(s)

AA320958, AC026696, DA361670, U26555

Consensus CDS

CCDS54875.1

UniProtKB/Swiss-Prot

P13611

Related

ENSP00000342768, ENST00000342785

Conserved Domains (7) summary

cd00054
Location:1373 – 1409
Blast Score: 141

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 443

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 457

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 565

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:1542 – 1598
Blast Score: 138

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:1415 – 1538
Blast Score: 657

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 150

V-set; Immunoglobulin V-set domain
NM_004385.4 → NP_004376.2 versican core protein isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1), also known as PG-M(V0), encodes the longest isoform (1).

Source sequence(s)

AB209491, AC026696, DA361670, DT217515, U16306

Consensus CDS

CCDS4060.1

UniProtKB/Swiss-Prot

P13611

UniProtKB/TrEMBL

Q59FG9

Related

ENSP00000265077, OTTHUMP00000161998, ENST00000265077, OTTHUMT00000254092

Conserved Domains (7) summary

cd00054
Location:3127 – 3163
Blast Score: 151

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd03517
Location:150 – 244
Blast Score: 451

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:251 – 346
Blast Score: 463

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cd05901
Location:36 – 151
Blast Score: 560

Ig_Versican; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), versican

cd00033
Location:3296 – 3352
Blast Score: 142

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03588
Location:3169 – 3292
Blast Score: 664

CLECT_CSPGs; C-type lectin-like domain (CTLD) of the type found in chondroitin sulfate proteoglycan core proteins

pfam07686
Location:29 – 147
Blast Score: 149

V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

82767493..82878122

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

77975785..78086373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC016568.5	None
genomic	AC020921.6	None
genomic	AC026696.5 (28452..125560)	None
genomic	CH471084.1	EAW95904.1
		EAW95905.1
		EAW95906.1
		EAW95907.1
		EAW95908.1
		EAW95909.1
		EAW95910.1
		EAW95911.1
genomic	S52488.1	AAB24878.1
mRNA	AA320958.1	None
mRNA	AA426499.1	None
mRNA	AA478645.1	None
mRNA	AB209491.1	BAD92728.1
mRNA	AF084545.1	AAD48545.1
mRNA	AK296285.1	BAH12302.1
mRNA	AK299770.1	BAH13124.1
mRNA	AK307642.1	None
mRNA	BC050524.1	AAH50524.1
mRNA	BP332680.1	None
mRNA	BX641036.1	CAE46022.1
mRNA	CN312093.1	None
mRNA	D32039.1	BAA06801.1
mRNA	DA361670.1	None
mRNA	DB497892.1	None
mRNA	DT217515.1	None
mRNA	J02814.1	AAA36437.1
mRNA	U16306.1	AAA65018.1
mRNA	U26555.1	AAA67565.1
mRNA	X15998.1	CAA34128.1
other-genetic	BC172276.1	AAI72276.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P13611.3	GenPept	UniProtKB/Swiss-Prot:P13611
Q59FG9	GenPept	UniProtKB/TrEMBL:Q59FG9
Q6MZK8	GenPept	UniProtKB/TrEMBL:Q6MZK8
Q86W61	GenPept	UniProtKB/TrEMBL:Q86W61