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    CSNK2B casein kinase 2, beta polypeptide [ Homo sapiens ]

    Gene ID: 1460, updated on 19-May-2012

    Summary

    Official Symbol
    CSNK2Bprovided by HGNC
    Official Full Name
    casein kinase 2, beta polypeptideprovided by HGNC
    Primary source
    HGNC:2460
    Locus tag
    DADB-127H9.2
    See related
    Ensembl:ENSG00000204435; Ensembl:ENSG00000263020; HPRD:00278; MIM:115441; Vega:OTTHUMG00000031056
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G5A; CK2B; CK2N; CSK2B; MGC138222; MGC138224
    Summary
    This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (31633657..31637843)
    See CSNK2B in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein M Neighboring gene chromosome 6 open reading frame 47 Neighboring gene G patch domain and ankyrin repeats 1 Neighboring gene lymphocyte antigen 6 complex, locus G5B Neighboring gene lymphocyte antigen 6 complex, locus G5C

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
    rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
    rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
    rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
    rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
    Vpu vpu The presence of the casein kinase II phosphorylation sites of HIV-1 Vpu enhances CD4(+) T cell loss in a non-human primate model for HIV-1 infection PubMed
    vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
    vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
    matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
    reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
    gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001311.3 NP_009227.1 BRCA1    BIND  PubMed BRCA1 is phosphorylated by Casein kinase 2 through a physical interaction with CSNK2B 
    NP_001311.3 CSNK2A1    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_A). 
    NP_001311.3 CSNK2A1    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_B). 
    NP_001311.3 CSNK2A1    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_B). 
    NP_001311.3 CSNK2A1    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_A). 
    NP_001311.3 CSNK2A1    BIND  PubMed CK2-alpha subunit interacts with CK2-beta subunit. 
    NP_001311.3 NP_001887.1 CSNK2A2    BIND  PubMed CK2-alpha' subunit interacts with CK2-beta subunit. 
    NP_001311.3 NP_001311.3 CSNK2B    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-beta subunit (PDB ID: 1JWH_C). 
    NP_001311.3 NP_001311.3 CSNK2B    BIND  PubMed CK2-beta subunit interacts with another copy of itself. 
    NP_001311.3 NP_003899.2 EIF2S2    BIND  PubMed EIF2beta interacts with CK2beta. 
    NP_001311.3 NC_000005.8 IRF1    BIND  PubMed CK2-beta interacts with IRF-1 promoter. 
    NP_001311.3 NP_000302.1 PRNP    BIND  PubMed PrPc interacts with CSNK2B (CK2 beta) albeit weakly. This interaction was modeled on a demonstrated interaction between bovine PrPc and human CSNK2B (CK2 beta). 
    NP_001311.3 NP_005451.1 SNCAIP    BIND  PubMed CK2B interacts with Synphilin-1. 
    NP_001311.3 NC_000005.8 TERF2    BIND  PubMed CK2-beta interacts with TAF7 promoter. 
    NP_001311.3 P10238     BIND  PubMed Human herpes simplex virus type 1 (HSV-1) protein IE63 interacts with CK2beta. 
    P67870 P10398 ARAF    HPRD  PubMed  
    P67870 P55957 BID    HPRD  PubMed  
    P67870 P38398 BRCA1    HPRD  PubMed  
    P67870 P20290 BTF3    HPRD  PubMed  
    P67870 Q86VB7 CD163    HPRD  PubMed  
    P67870 P30305 CDC25B    HPRD  PubMed  
    P67870 P49427 CDC34    HPRD  PubMed  
    P67870 P06493 CDK1    HPRD  PubMed  
    P67870 Q8IZL9 CDK20    HPRD  PubMed  
    P67870 P38936 CDKN1A    HPRD  PubMed  
    P67870 O14757 CHEK1    HPRD  PubMed  
    P67870 P38432 COIL    HPRD  PubMed  
    P67870 P68400 CSNK2A1    HPRD  PubMed  
    P67870 P19784 CSNK2A2    HPRD  PubMed  
    P67870 P67870 CSNK2B    HPRD  PubMed  
    P67870 Q9Y5B0 CTDP1    HPRD  PubMed  
    P67870 P35222 CTNNB1    HPRD  PubMed  
    P67870 P20042 EIF2S2    HPRD  PubMed  
    P67870 P55010 EIF5    HPRD  PubMed  
    P67870 P03372 ESR1    HPRD  PubMed  
    P67870 Q9UNN5 FAF1    HPRD  PubMed  
    P67870 P05230 FGF1    HPRD  PubMed  
    P67870 P09038 FGF2    HPRD  PubMed  
    P67870 O43427 FIBP    HPRD  PubMed  
    P67870 Q00688 FKBP3    HPRD  PubMed  
    P67870 Q8TAE8 GADD45GIP1    HPRD  PubMed  
    P67870 P17509 HOXB6    HPRD  PubMed  
    P67870 P35568 IRS1    HPRD  PubMed  
    P67870 P07948 LYN    HPRD  PubMed  
    P67870 Q99698 LYST    HPRD  PubMed  
    P67870 Q16539 MAPK14    HPRD  PubMed  
    P67870 O95243 MBD4    HPRD  PubMed  
    P67870 P08473 MME    HPRD  PubMed  
    P67870 P14598 NCF1    HPRD  PubMed  
    P67870 Q14978 NOLC1    HPRD  PubMed  
    P67870 Q16625 OCLN    HPRD  PubMed  
    P67870 Q13526 PIN1    HPRD  PubMed  
    P67870 Q05513 PRKCZ    HPRD  PubMed  
    P67870 P04156 PRNP    HPRD  PubMed  
    P67870 Q9UBF6 RNF7    HPRD  PubMed  
    P67870 P62945 RPL41    HPRD  PubMed  
    P67870 P46777 RPL5    HPRD  PubMed  
    P67870 P23443 RPS6KB1    HPRD  PubMed  
    P67870 P34896 SHMT1    HPRD  PubMed  
    P67870 P34897 SHMT2    HPRD  PubMed  
    P67870 Q02880 TOP2B    HPRD  PubMed  
    P67870 P04637 TP53    HPRD  PubMed  
    P67870 O60763 USO1    HPRD  PubMed  
    P67870 P15621 ZNF44    HPRD  PubMed  
    P67870 O43257 ZNHIT1    HPRD  PubMed  
    BioGRID:107843 BioGRID:121967 ABHD4    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:119529 ACTL6B    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:115424 ACTR1B    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:122993 ACTR5    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106631 ADD1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106665 ADRBK1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106782 ANGPT2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:106830 APLP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106864 ARAF    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:106956 ATF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107843 BioGRID:113647 BAG6    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:121161 BCCIP    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:107154 BTF3    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:121948 C12orf44    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:127856 C19orf46    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:131981 C5orf25    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:128738 C6orf136    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:119567 C9orf114    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107227 CACNA1A    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107843 BioGRID:124043 CCDC115    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114741 CD163    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:107432 CDC34    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107843 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:107460 CDKN1A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107843 BioGRID:107488 CENPB    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107559 CHRNA4    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116767 CIC    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107681 COL4A2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:118023 CPNE7    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:120310 CPSF3L    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107841 CSNK2A1    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:107842 CSNK2A2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western; Two-hybrid 
    BioGRID:107843 BioGRID:107843 CSNK2B    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:119486 DACT1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:120455 DALRD3    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116861 DENND5A    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:108123 DNMT1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:108117 DYNC1H1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:114214 EIF3F    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:114216 EIF3H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:109898 EIF6    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107581 ERCC8    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116298 FAF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:117625 FBXL5    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:108515 FCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:108537 FGF1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:107843 BioGRID:108538 FGF2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107843 BioGRID:124721 GADD45GIP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:108904 GBP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:108984 GLB1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:115920 GNB5    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:109323 HEXB    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114053 HIRIP3    BioGRID  PubMed Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107843 BioGRID:119311 IER3IP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:112351 ITSN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116752 KDM6B    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116195 KIF2C    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110124 LCK    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110144 LEPR    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114113 LMO4    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:124819 LRP5L    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110245 LYN    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:107552 LYST    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:110287 MAGEB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:107819 MAPK14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:114444 MBD4    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:115710 MCRS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:121122 MEPCE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:115948 MGEA5    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:117478 MOXD1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110495 MPP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110754 NAP1L1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:575724 NCF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:114794 NMT2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114654 NOLC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107843 BioGRID:110916 NOTCH3    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:118995 NRBP1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111007 ODC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116848 PDS5A    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111231 PFKFB4    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111323 PITPNA    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:120717 PLXNA3    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111477 PPID    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107843 BioGRID:111608 PROC    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111760 PTPRK    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:124263 PYROXD2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:111913 RFC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:120790 RNF126    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114977 RNF7    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107843 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:112037 RPA1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:112057 RPL13    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:112045 RPL5    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:112112 RPS6KB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107843 BioGRID:112168 RXRA    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:249866 Rps6kb1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:124049 SARNP    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:112290 SDHA    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107843 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:115544 SRRM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:112657 STAU1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:114144 STK16    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:112497 SUMO2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:122548 TAF1D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:121209 TCEAL7    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:129118 TCTEX1D2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:112872 TERF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:112873 TERF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:112943 TLE1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:113008 TOP2B    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:113012 TP53BP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:121756 TRIB3    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107843 BioGRID:129721 TSEN54    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:131483 TUBB2B    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:111908 UPF1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:116026 UTP14A    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:113259 VDAC1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:119394 VRK3    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:115273 WDR1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:121517 WDR18    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:121649 WDR48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107843 BioGRID:125565 WFIKKN1    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:121821 ZNF71    BioGRID  PubMed Two-hybrid 
    BioGRID:107843 BioGRID:127091 ZNF784    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Potential readthrough

    Included gene: LY6G5B

    Homology

    Pathways from BioSystems

    • ALK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      ALK1 signaling events, organism-specific biosystem
      ALK1 signaling events
    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase regulator activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    contributes_to protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adiponectin-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cellular protein complex assembly NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with PcG protein complex IDA
    Inferred from Direct Assay
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    colocalizes_with plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase CK2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase CK2 complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase II subunit beta
    Names
    casein kinase II subunit beta
    phosvitin
    CK II beta
    protein G5a
    Casein kinase II beta subunit
    alternative name: G5a, phosvitin
    NP_001311.3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320.5NP_001311.3  casein kinase II subunit beta

      Status: REVIEWED

      Source sequence(s)
      X57152
      Consensus CDS
      CCDS4712.1
      UniProtKB/TrEMBL
      B0UXA9
      UniProtKB/Swiss-Prot
      P67870
      Related
      ENSP00000365042, OTTHUMP00000029060, ENST00000375882, OTTHUMT00000076063
      Conserved Domains (1) summary
      cl02099
      Location:8191
      Blast Score: 883
      CK_II_beta; Casein kinase II regulatory subunit

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      31633657..31637843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p5 ALT_REF_LOCI_2

      Range
      3143277..3147463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p5 ALT_REF_LOCI_3

      Range
      2919236..2923423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p5 ALT_REF_LOCI_4

      Range
      2976547..2980733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p5 ALT_REF_LOCI_5

      Range
      3013337..3017523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p5 ALT_REF_LOCI_6

      Range
      2927300..2931486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p5 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p5 ALT_REF_LOCI_7

      Range
      2964462..2968648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      31419882..31424068
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF129756.1 AAD18081.1
    genomic AL662899.5 (8219..12405) None
    genomic AL670886.6 (18535..22721) None
    genomic AL805934.3 CAI18521.2
      CAI18523.1
    genomic BA000025.2 BAB63386.1
    genomic BX511262.7 CAM45825.1
    genomic CH471081.1 EAX03472.1
      EAX03473.1
      EAX03474.1
      EAX03475.1
    genomic CR354443.4 CAQ07001.1
      CAQ07002.1
    genomic CR753842.3 CAQ06572.1
    genomic CR759761.9 CAQ10879.1
    genomic DQ314868.1 ABC40727.1
    genomic X57152.1 CAA40442.1
    mRNA AK300671.1 BAG62356.1
    mRNA AK308742.1 None
    mRNA AK310551.1 None
    mRNA AK311860.1 BAG34801.1
    mRNA AY113186.1 AAM50092.1
    mRNA BC112017.1 AAI12018.1
    mRNA BC112019.1 AAI12020.1
    mRNA CR541699.1 CAG46500.1
    mRNA X16312.1 CAA34379.1
    mRNA X16937.1 CAA34811.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P67870.1 GenPept UniProtKB/Swiss-Prot:P67870
    Q5SRQ6 GenPept UniProtKB/TrEMBL:Q5SRQ6

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