B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 [Mus musculus] - Gene

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Summary

Official Symbol: B4galt1provided by MGI
Official Full Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1provided by MGI
Primary source: MGI:95705
Locus tag: RP23-135L5.6
See related: Ensembl:ENSMUSG00000028413; Vega:OTTMUSG00000006610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GalT; Ggtb; Ggtb2; AA407245; B-1,4-GalT

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Genomic context

Location :: 4 A5; 4 18.6 cM

Sequence :: Chromosome: 4; NC_000070.6 (40804602..40853998, complement)

See B4galt1 in Epigenomics, MapViewer

Chromosome 4 - NC_000070.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
Title: Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis.
the beta4-galactosyltransferase-1 coding sequence does not contain functional elements that affect the intrinsic stability of this mRNA
Title: Determination of the half-life of the murine beta4-galactosyltransferase-1 mRNA in somatic cells using the tetracycline-controlled transcriptional regulation system.
REVIEW: Function in mammary gland morphogenesis: insights from transgenic and knockout mouse models
Title: Cell surface beta1,4-galactosyltransferase function in mammary gland morphogenesis: insights from transgenic and knockout mouse models.
beta4GalT-I is a major galactosyltransferase responsible for selectin-ligand biosynthesis and that inflammatory responses of beta4GalT-I-deficient mice are impaired because of the defect in selectin-ligand biosynthesis.
Title: Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferase-I-deficient mice.
regulation of expression by focal adhesion kinase
Title: Regulation of the expression and activity of beta1,4-galactosyltransferase I by focal adhesion kinase.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:199912	BioGRID:108950	B4GALT1		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
N-acetyllactosamine synthase activity	ISO Inferred from Sequence Orthology more info
UDP-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	ISO Inferred from Sequence Orthology more info
beta-tubulin binding	ISO Inferred from Sequence Orthology more info
cytoskeletal protein binding	IDA Inferred from Direct Assay more info	PubMed
galactosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
lactose synthase activity	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring glycosyl groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acute inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
angiogenesis involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
binding of sperm to zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
binding of sperm to zona pellucida	IPI Inferred from Physical Interaction more info	PubMed
branching morphogenesis of a tube	IMP Inferred from Mutant Phenotype more info	PubMed
carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
development of secondary sexual characteristics	IMP Inferred from Mutant Phenotype more info	PubMed
epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
galactose metabolic process	IDA Inferred from Direct Assay more info	PubMed
glycoprotein biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
lactose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
mammary gland development	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
oligosaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
penetration of zona pellucida	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptosis involved in mammary gland involution	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of epithelial cell proliferation involved in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of acrosome reaction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of cellular component movement	IDA Inferred from Direct Assay more info	PubMed
wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
Golgi apparatus	ISO Inferred from Sequence Orthology more info
Golgi trans cisterna	ISO Inferred from Sequence Orthology more info
basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
brush border membrane	ISO Inferred from Sequence Orthology more info
cell surface	IDA Inferred from Direct Assay more info	PubMed
cell surface	IMP Inferred from Mutant Phenotype more info	PubMed
desmosome	ISO Inferred from Sequence Orthology more info
external side of plasma membrane	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
glycocalyx	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: beta-1,4-galactosyltransferase 1

Names: beta-1,4-galactosyltransferase 1; b4Gal-T1; B-1,4-GalT1; beta4Gal-T1; beta-1,4-GalT; beta-1,4-GalT1; beta-1,4-GalTase 1; b1,4-Galactosyltransferase I; beta 1,4-Galactosyltransferase I; galactosyltransferase 2 beta 1, 4; beta-1,4-galactosyltransferase (short form); glycoprotein galactosyltransferase beta 1, 4; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1; UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1

NP_071641.1

EC 2.4.1.22

EC 2.4.1.38

EC 2.4.1.90

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022305.3 → NP_071641.1 beta-1,4-galactosyltransferase 1

Status: PROVISIONAL

Source sequence(s)

AL833775

Consensus CDS

CCDS18051.1

UniProtKB/Swiss-Prot

P15535

UniProtKB/TrEMBL

Q3U478

Related

ENSMUSP00000030121, OTTMUSP00000006967, ENSMUST00000030121, OTTMUST00000015075

Conserved Domains (1) summary

cd00899
Location:176 – 394
Blast Score: 1052

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids.

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000070.6 Reference GRCm38 C57BL/6J

Range

40804602..40853998, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000026.1 Alternate Mm_Celera

Range

40465334..40514995, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL833775.7	CAM14781.1
		CAM14782.1
genomic	CH466538.2	EDL05426.1	mixed
		EDL05427.1	mixed
genomic	M27917.1	None
genomic	M27918.1	None
genomic	M27919.1	None
genomic	M27920.1	None
genomic	M27921.1	None
genomic	M27922.1	AAA58744.1
		AAA58745.1
genomic	M27923.1	None
mRNA	AK029474.1	None	C57BL/6J
mRNA	AK131721.1	None	C57BL/6J
mRNA	AK132970.1	BAE21450.1	C57BL/6J
mRNA	AK154393.1	BAE32556.1	NOD
mRNA	AK154683.1	None	NOD
mRNA	AK167322.1	BAE39424.1	C57BL/6J
mRNA	AK210987.1	None
mRNA	AK213053.1	None
mRNA	AK214993.1	None
mRNA	BC026824.1	AAH26824.1
mRNA	BC053006.1	AAH53006.1	C57BL/6
mRNA	D00314.1	BAA00216.1
mRNA	J03880.1	AAA37297.1
mRNA	L16840.1	AAA62340.1	BALB/c
mRNA	M36289.1	AAA37295.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P15535.1	GenPept	UniProtKB/Swiss-Prot:P15535
Q05CE5	GenPept	UniProtKB/TrEMBL:Q05CE5
Q3TJS1	GenPept	UniProtKB/TrEMBL:Q3TJS1
Q3U478	GenPept	UniProtKB/TrEMBL:Q3U478
Q6LDL0	GenPept	UniProtKB/TrEMBL:Q6LDL0