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MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 [ Homo sapiens (human) ]

Gene ID: 145873, updated on 4-May-2015
Official Symbol
MESP2provided by HGNC
Official Full Name
mesoderm posterior basic helix-loop-helix transcription factor 2provided by HGNC
Primary source
HGNC:HGNC:29659
See related
Ensembl:ENSG00000188095; MIM:605195; Vega:OTTHUMG00000172016
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCDO2; bHLHc6
Summary
This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]
Orthologs
See MESP2 in MapViewer
Location:
15q26.1
Exon count:
2
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (89776358..89778754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90319589..90321985)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L15 pseudogene 1 Neighboring gene mesoderm posterior basic helix-loop-helix transcription factor 1 Neighboring gene alanyl (membrane) aminopeptidase Neighboring gene uncharacterized LOC105370965

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
mesodermal cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
somite rostral/caudal axis specification IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
mesoderm posterior protein 2
Names
mesoderm posterior protein 2
class C basic helix-loop-helix protein 6
mesoderm posterior 2 homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008608.1 RefSeqGene

    Range
    5001..7397
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039958.1NP_001035047.1  mesoderm posterior protein 2

    See identical proteins and their annotated locations for NP_001035047.1

    Status: REVIEWED

    Source sequence(s)
    AC079075, BK000142
    Consensus CDS
    CCDS42078.1
    UniProtKB/Swiss-Prot
    Q0VG99
    Related
    ENSP00000342392, OTTHUMP00000247433, ENST00000341735, OTTHUMT00000416421
    Conserved Domains (1) summary
    cd00083
    Location:82139
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    89776358..89778754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    90160596..90162992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)