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Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 14585, updated on 24-Jan-2015
Official Symbol
Gfra1provided by MGI
Official Full Name
glial cell line derived neurotrophic factor family receptor alpha 1provided by MGI
Primary source
MGI:MGI:1100842
See related
Ensembl:ENSMUSG00000025089; Vega:OTTMUSG00000033056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU042498
Orthologs
See Gfra1 in MapViewer
Location:
19 D2-D3; 19 54.18 cM
Exon count:
18
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 19 NC_000085.6 (58235581..58455946, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene attractin like 1 Neighboring gene predicted gene, 32980 Neighboring gene microRNA 5623 Neighboring gene predicted gene, 33133 Neighboring gene predicted gene 10007 Neighboring gene predicted gene, 33306 Neighboring gene coiled-coil domain containing 172

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
integrin binding ISO
Inferred from Sequence Orthology
more info
 
receptor activity ISO
Inferred from Sequence Orthology
more info
 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
neuron projection development ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
GDNF family receptor alpha-1
Names
GDNF family receptor alpha-1
GDNFR-alpha
GFR alpha-1
GFR-alpha-1
GDNFR-alpha-1
GDNF receptor alpha-1
TGF-beta-related neurotrophic factor receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285457.1NP_001272386.1  GDNF family receptor alpha-1 isoform 2 precursor

    See proteins identical to NP_001272386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a shorter 5' UTR and lacks an exon in the central coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102457, AC102610
    Consensus CDS
    CCDS70967.1
    UniProtKB/Swiss-Prot
    P97785
    Related
    ENSMUSP00000117196, OTTMUSP00000044240, ENSMUST00000129100, OTTMUST00000082536
    Conserved Domains (1) summary
    pfam02351
    Location:238332
    GDNF; GDNF/GAS1 domain
  2. NM_010279.3NP_034409.1  GDNF family receptor alpha-1 isoform 1 precursor

    See proteins identical to NP_034409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102457, AC102610, AK076171, BY233103
    Consensus CDS
    CCDS38028.1
    UniProtKB/Swiss-Prot
    P97785
    Related
    ENSMUSP00000026076, OTTMUSP00000044237, ENSMUST00000026076, OTTMUST00000082533
    Conserved Domains (1) summary
    pfam02351
    Location:243337
    GDNF; GDNF/GAS1 domain

RNA

  1. NR_104342.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon at the 3' end, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC102457, AC102610

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000085.6 

    Range
    58235581..58455946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526681.1XP_006526744.1  

    See proteins identical to XP_006526744.1

    UniProtKB/Swiss-Prot
    P97785
    Conserved Domains (1) summary
    pfam02351
    Location:243337
    GDNF; GDNF/GAS1 domain
  2. XM_006526685.1XP_006526748.1  

    See proteins identical to XP_006526748.1

    UniProtKB/Swiss-Prot
    P97785
    Conserved Domains (1) summary
    pfam02351
    Location:238332
    GDNF; GDNF/GAS1 domain
  3. XM_006526682.1XP_006526745.1  

    See proteins identical to XP_006526745.1

    UniProtKB/Swiss-Prot
    P97785
    Conserved Domains (1) summary
    pfam02351
    Location:243337
    GDNF; GDNF/GAS1 domain
  4. XM_006526684.1XP_006526747.1  

    See proteins identical to XP_006526747.1

    UniProtKB/Swiss-Prot
    P97785
    Conserved Domains (1) summary
    pfam02351
    Location:243337
    GDNF; GDNF/GAS1 domain
  5. XM_006526683.1XP_006526746.1  

    See proteins identical to XP_006526746.1

    UniProtKB/Swiss-Prot
    P97785
    Conserved Domains (1) summary
    pfam02351
    Location:243337
    GDNF; GDNF/GAS1 domain
  6. XM_006526687.1XP_006526750.1  

    Conserved Domains (1) summary
    pfam02351
    Location:99193
    GDNF; GDNF/GAS1 domain
  7. XM_006526686.1XP_006526749.1  

    Conserved Domains (1) summary
    pfam02351
    Location:122216
    GDNF; GDNF/GAS1 domain

Alternate Mm_Celera

Genomic

  1. AC_000041.1 

    Range
    60428888..60651403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)