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    CSNK2A1 casein kinase 2, alpha 1 polypeptide [ Homo sapiens ]

    Gene ID: 1457, updated on 20-May-2012

    Summary

    Official Symbol
    CSNK2A1provided by HGNC
    Official Full Name
    casein kinase 2, alpha 1 polypeptideprovided by HGNC
    Primary source
    HGNC:2457
    See related
    Ensembl:ENSG00000101266; HPRD:00277; MIM:115440; Vega:OTTHUMG00000031636
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKII; CK2A1
    Summary
    Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    20p13
    Sequence :
    Chromosome: 20; NC_000020.10 (463338..524482, complement)
    See CSNK2A1 in Epigenomics, MapViewer

    Chromosome 20 - NC_000020.10Genomic Context describing neighboring genes Neighboring gene RanBP-type and C3HC4-type zinc finger containing 1 Neighboring gene TBC1 domain family, member 20 Neighboring gene transcription factor 15 (basic helix-loop-helix) Neighboring gene sulfiredoxin 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev CK2 modulates the interaction of Rev with nucleolar phosphoprotein B23 by phosphorylating B23 PubMed
    rev Rev activates CK2, an effect hypothesized to promote HIV-1 replication PubMed
    rev phosphorylation of Rev is dependent on the beta subunit of CK2 PubMed
    rev amino acids 35-50 of Rev are involved with electrostatic interactions with CK2 while amino acids 12-24 of Rev are involved with hydrophobic interactions PubMed
    rev CK2 phosphorylates Rev on Serine 5 and Serine 8 PubMed
    Vpu vpu Phosphorylation of HIV-1 Vpu by casein kinase 2 is required for Vpu-mediated degradation of CD4, regulation of HIV-1 envelope secretion and control of syncytium formation PubMed
    vpu The HIV-1 Vpu protein is phosphorylated by casein kinase 2 on serine amino acids 52 and 56 PubMed
    matrix gag CK2 has been shown to phosphorylate HIV-1 Matrix in vitro PubMed
    retropepsin gag-pol Purified recombinant HIV-1 protease (rPR) is phosphorylated by casein kinase II, and the activity of rPR is stimulated approximately 2.9-fold as a result of this phosphorylation PubMed
    reverse transcriptase gag-pol Casein kinase II phosphorylates HIV-1 RT p66 and p51 in human cells PubMed
    gag-pol Phosphorylation of HIV-1 RT p66 and p51 by Casein kinase II mediates the stimulation of RNA-dependent DNA polymerase (RDDP) activity in vitro PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001886.1 NP_002458.1 MYC    BIND  PubMed CK2 interacts with and phosphorylates c-Myc. This interaction was modelled on a demonstrated interaction between mouse CK2 and human c-Myc. 
    NP_001886.1 NP_000302.1 PRNP    BIND  PubMed PrPc interacts with CSNK2A1 (CK2 alpha). This interaction was modeled on a demonstrated interaction between bovine PrPc and human CSNK2A1 (CK2 alpha). 
    NP_808227.1 NP_003899.2 EIF2S2    BIND  PubMed EIF2beta interacts with CK2alpha. 
    P68400 O95477 ABCA1    HPRD  PubMed  
    P68400 Q13085 ACACA    HPRD  PubMed  
    P68400 Q9BWD1 ACAT2    HPRD  PubMed  
    P68400 O00170 AIP    HPRD  PubMed  
    P68400 P27695 APEX1    HPRD  PubMed  
    P68400 P55087 AQP4    HPRD  PubMed  
    P68400 P27540 ARNT    HPRD  PubMed  
    P68400 P36575 ARR3    HPRD  PubMed  
    P68400 P32121 ARRB2    HPRD  PubMed  
    P68400 Q9UHC3 ASIC3    HPRD  PubMed  
    P68400 P18846 ATF1    HPRD  PubMed  
    P68400 P15336 ATF2    HPRD  PubMed  
    P68400 Transcription factor like nuclear regulator BDP1    HPRD  PubMed  
    P68400 P55957 BID    HPRD  PubMed  
    P68400 P38398 BRCA1    HPRD  PubMed  
    P68400 Q92994 BRF1    HPRD  PubMed  
    P68400 P00736 C1R    HPRD  PubMed  
    P68400 Calmodulin 1 CALM1    HPRD  PubMed  
    P68400 P42575 CASP2    HPRD  PubMed  
    P68400 O14958 CASQ2    HPRD  PubMed  
    P68400 Q03135 CAV1    HPRD  PubMed  
    P68400 P06127 CD5    HPRD  PubMed  
    P68400 P30305 CDC25B    HPRD  PubMed  
    P68400 Q16543 CDC37    HPRD  PubMed  
    P68400 P12830 CDH1    HPRD  PubMed  
    P68400 P06493 CDK1    HPRD  PubMed  
    P68400 P38936 CDKN1A    HPRD  PubMed  
    P68400 Q9UEE9 CFDP1    HPRD  PubMed  
    P68400 P09497 CLTB    HPRD  PubMed  
    P68400 Q92793 CREBBP    HPRD  PubMed  
    P68400 Q03060 CREM    HPRD  PubMed  
    P68400 P68400 CSNK2A1    HPRD  PubMed  
    P68400 P67870 CSNK2B    HPRD  PubMed  
    P68400 Q9Y5B0 CTDP1    HPRD  PubMed  
    P68400 P35222 CTNNB1    HPRD  PubMed  
    P68400 O14529 CUX2    HPRD  PubMed  
    P68400 P35638 DDIT3    HPRD  PubMed  
    P68400 O14640 DVL1    HPRD  PubMed  
    P68400 Q92997 DVL3    HPRD  PubMed  
    P68400 P24534 EEF1B2    HPRD  PubMed  
    P68400 P29692 EEF1D    HPRD  PubMed  
    P68400 P18146 EGR1    HPRD  PubMed  
    P68400 Q13144 EIF2B5    HPRD  PubMed  
    P68400 P20042 EIF2S2    HPRD  PubMed  
    P68400 Q13541 EIF4EBP1    HPRD  PubMed  
    P68400 P55010 EIF5    HPRD  PubMed  
    P68400 P84090 ERH    HPRD  PubMed  
    P68400 Q9Y624 F11R    HPRD  PubMed  
    P68400 P12259 F5    HPRD  PubMed  
    P68400 Q9UNN5 FAF1    HPRD  PubMed  
    P68400 P05230 FGF1    HPRD  PubMed  
    P68400 P09038 FGF2    HPRD  PubMed  
    P68400 O43427 FIBP    HPRD  PubMed  
    P68400 Q00688 FKBP3    HPRD  PubMed  
    P68400 Q02790 FKBP4    HPRD  PubMed  
    P68400 P20930 FLG    HPRD  PubMed  
    P68400 P01100 FOS    HPRD  PubMed  
    P68400 P24046 GABRR1    HPRD  PubMed  
    P68400 P28476 GABRR2    HPRD  PubMed  
    P68400 P17677 GAP43    HPRD  PubMed  
    P68400 P60983 GMFB    HPRD  PubMed  
    P68400 P06744 GPI    HPRD  PubMed  
    P68400 P52655 GTF2A1    HPRD  PubMed  
    P68400 Q9UNN4 GTF2A1L    HPRD  PubMed  
    P68400 P13807 GYS1    HPRD  PubMed  
    P68400 P14317 HCLS1    HPRD  PubMed  
    P68400 Q13547 HDAC1    HPRD  PubMed  
    P68400 Q92769 HDAC2    HPRD  PubMed  
    P68400 O15379 HDAC3    HPRD  PubMed  
    P68400 Q96HZ4 HES6    HPRD  PubMed  
    P68400 Q16665 HIF1A    HPRD  PubMed  
    P68400 P17096 HMGA1    HPRD  PubMed  
    P68400 P52926 HMGA2    HPRD  PubMed  
    P68400 P30519 HMOX2    HPRD  PubMed  
    P68400 P22626 HNRNPA2B1    HPRD  PubMed  
    P68400 P09629 HOXB7    HPRD  PubMed  
    P68400 Q00613 HSF1    HPRD  PubMed  
    P68400 P07900 HSP90AA1    HPRD  PubMed  
    P68400 P14625 HSP90B1    HPRD  PubMed  
    P68400 Q9UJY1 HSPB8    HPRD  PubMed  
    P68400 Q92598 HSPH1    HPRD  PubMed  
    P68400 Q16666 IFI16    HPRD  PubMed  
    P68400 P17936 IGFBP3    HPRD  PubMed  
    P68400 Q14005 IL16    HPRD  PubMed  
    P68400 P14316 IRF2    HPRD  PubMed  
    P68400 P35568 IRS1    HPRD  PubMed  
    P68400 P05412 JUN    HPRD  PubMed  
    P68400 O43896 KIF1C    HPRD  PubMed  
    P68400 Q13351 KLF1    HPRD  PubMed  
    P68400 P32004 L1CAM    HPRD  PubMed  
    P68400 P17931 LGALS3    HPRD  PubMed  
    P68400 P18858 LIG1    HPRD  PubMed  
    P68400 P61244 MAX    HPRD  PubMed  
    P68400 P56270 MAZ    HPRD  PubMed  
    P68400 Q06413 MEF2C    HPRD  PubMed  
    P68400 P16455 MGMT    HPRD  PubMed  
    P68400 P11836 MS4A1    HPRD  PubMed  
    P68400 P10242 MYB    HPRD  PubMed  
    P68400 P01106 MYC    HPRD  PubMed  
    P68400 P04198 MYCN    HPRD  PubMed  
    P68400 P13349 MYF5    HPRD  PubMed  
    P68400 Q99733 NAP1L4    HPRD  PubMed  
    P68400 P14598 NCF1    HPRD  PubMed  
    P68400 P19338 NCL    HPRD  PubMed  
    P68400 P25963 NFKBIA    HPRD  PubMed  
    P68400 P52952 NKX2-5    HPRD  PubMed  
    P68400 O60936 NOL3    HPRD  PubMed  
    P68400 Q14978 NOLC1    HPRD  PubMed  
    P68400 O15294 OGT    HPRD  PubMed  
    P68400 Q6VY07 PACS1    HPRD  PubMed  
    P68400 P43034 PAFAH1B1    HPRD  PubMed  
    P68400 Q13153 PAK1    HPRD  PubMed  
    P68400 P06401 PGR    HPRD  PubMed  
    P68400 Q13526 PIN1    HPRD  PubMed  
    P68400 Q9Y237 PIN4    HPRD  PubMed  
    P68400 Casein kinase II interacting protein 1 PLEKHO1    HPRD  PubMed  
    P68400 P29590 PML    HPRD  PubMed  
    P68400 Q9UD71 PPP1R1B    HPRD  PubMed  
    P68400 P41236 PPP1R2    HPRD  PubMed  
    P68400 Q12972 PPP1R8    HPRD  PubMed  
    P68400 Q15257 PPP2R4    HPRD  PubMed  
    P68400 P04156 PRNP    HPRD  PubMed  
    P68400 P49810 PSEN2    HPRD  PubMed  
    P68400 P25788 PSMA3    HPRD  PubMed  
    P68400 P25789 PSMA4    HPRD  PubMed  
    P68400 P60484 PTEN    HPRD  PubMed  
    P68400 P18031 PTPN1    HPRD  PubMed  
    P68400 P08575 PTPRC    HPRD  PubMed  
    P68400 P46060 RANGAP1    HPRD  PubMed  
    P68400 Q04206 RELA    HPRD  PubMed  
    P68400 P49795 RGS19    HPRD  PubMed  
    P68400 Q9UBF6 RNF7    HPRD  PubMed  
    P68400 P46777 RPL5    HPRD  PubMed  
    P68400 P55042 RRAD    HPRD  PubMed  
    P68400 P21673 SAT1    HPRD  PubMed  
    P68400 P36955 SERPINF1    HPRD  PubMed  
    P68400 O15266 SHOX    HPRD  PubMed  
    P68400 Q05940 SLC18A2    HPRD  PubMed  
    P68400 P37840 SNCA    HPRD  PubMed  
    P68400 P08047 SP1    HPRD  PubMed  
    P68400 Q01892 SPIB    HPRD  PubMed  
    P68400 P10451 SPP1    HPRD  PubMed  
    P68400 Q01082 SPTBN1    HPRD  PubMed  
    P68400 Q8WXA9 SREK1    HPRD  PubMed  
    P68400 P11831 SRF    HPRD  PubMed  
    P68400 Q08945 SSRP1    HPRD  PubMed  
    P68400 P16949 STMN1    HPRD  PubMed  
    P68400 Q16623 STX1A    HPRD  PubMed  
    P68400 P53999 SUB1    HPRD  PubMed  
    P68400 Q9NQB0 TCF7L2    HPRD  PubMed  
    P68400 P07101 TH    HPRD  PubMed  
    P68400 P11387 TOP1    HPRD  PubMed  
    P68400 P11388 TOP2A    HPRD  PubMed  
    P68400 P04637 TP53    HPRD  PubMed  
    P68400 Q01534 TSPY1    HPRD  PubMed  
    P68400 Q712K3 UBE2R2    HPRD  PubMed  
    P68400 P17480 UBTF    HPRD  PubMed  
    P68400 O75379 VAMP4    HPRD  PubMed  
    P68400 P11473 VDR    HPRD  PubMed  
    P68400 P04004 VTN    HPRD  PubMed  
    P68400 P42768 WAS    HPRD  PubMed  
    P68400 P30291 WEE1    HPRD  PubMed  
    P68400 P51811 XK    HPRD  PubMed  
    P68400 P18887 XRCC1    HPRD  PubMed  
    P68400 Q13426 XRCC4    HPRD  PubMed  
    P68400 P31946 YWHAB    HPRD  PubMed  
    P68400 P27348 YWHAQ    HPRD  PubMed  
    P68400 Q9UKY1 ZHX1    HPRD  PubMed  
    NP_005154.2 AKT1    BIND  PubMed CK2 interacts with and phosphorylates Akt. This interaction was modeled on a demonstrated interaction between human CK2 and Akt from an unspecified species and mouse. 
    BioGRID:107841 BioGRID:106821 APC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:106900 ARR3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:106901 ARRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:6492 AT3G03773    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:106956 ATF1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Far Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:107776 ATF2    BioGRID  PubMed Far Western; Reconstituted Complex 
    AAG30220.1 BDP1    BIND  PubMed CK2alpha interacts with Bdp1. 
    BioGRID:107841 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107841 BioGRID:109227 BRF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:107252 CALM1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:107429 CDC25B    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:32107 CDC34    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:107532 CHD3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:107536 CHEK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-MS; Far Western; Reconstituted Complex 
    NP_001311.3 CSNK2B    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_A). 
    NP_001311.3 CSNK2B    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_D) and CK2-alpha subunit (PDB ID: 1JWH_B). 
    NP_001311.3 CSNK2B    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_B). 
    NP_001311.3 CSNK2B    BIND  PubMed Interaction between CK2-beta subunit (PDB ID: 1JWH_C) and CK2-alpha subunit (PDB ID: 1JWH_A). 
    NP_001311.3 CSNK2B    BIND  PubMed CK2-alpha subunit interacts with CK2-beta subunit. 
    BioGRID:107841 BioGRID:107843 CSNK2B    BioGRID  PubMed Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107841 BioGRID:108016 DDIT3    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:108188 DVL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:108189 DVL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:108190 DVL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:108256 EEF1D    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:114214 EIF3F    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:114216 EIF3H    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:108515 FCP1    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity 
    BioGRID:107841 BioGRID:108537 FGF1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:108538 FGF2    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:108636 FOS    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:108843 GABRR1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:119246 GMNN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:109217 GTF2F1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:109309 HCLS1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107841 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    NP_003874.2 HDAC3    BIND  PubMed CSNK2A1 (CK2) phosphorylates HDAC3. 
    BioGRID:107841 BioGRID:114368 HDAC3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:114053 HIRIP3    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:109422 HNRNPA2B1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:35923 HSP82    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:109552 HSP90AA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107841 BioGRID:113036 HSP90B1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107841 BioGRID:109790 IL8    BioGRID  PubMed Biochemical Activity 
    NC_000005.8 IRF1    BIND  PubMed An unspecified isoform of CK2-alpha interacts with IRF-1 promoter. 
    BioGRID:107841 BioGRID:109868 IRF2    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:109928 JUN    BioGRID  PubMed Far Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:110001 KIF5C    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107841 BioGRID:115904 KLF1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:32058 MAF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:123965 MAF1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:107819 MAPK14    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:110320 MAZ    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:110411 MGMT    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:110444 MLLT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:110455 MME    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:110698 MYCN    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:114049 OGT    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:120816 PACS1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107841 BioGRID:111085 PAFAH1B1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:119355 PLEKHO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107841 BioGRID:111469 PPBP    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:123915 PPP1R1B    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:111658 PSMA4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:111700 PTEN    BioGRID  PubMed Affinity Capture-MS; Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107841 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:112045 RPL5    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:112112 RPS6KB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107841 BioGRID:109072 SFN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:112566 SPI1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:112567 SPIB    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:112600 SRF    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:112735 TAF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107841 BioGRID:122548 TAF1D    BioGRID  PubMed Affinity Capture-MS 
    NC_000005.8 TAF7    BIND  PubMed CK2-alpha interacts with TAF7 promoter. 
    BioGRID:107841 BioGRID:112995 TNP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107841 BioGRID:113003 TOP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:113109 TSPY1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:113190 UBTF    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107841 BioGRID:114222 VAMP4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:113293 WAS    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:121649 WDR48    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:113341 XK    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:114538 XKRY    BioGRID  PubMed Biochemical Activity 
    BioGRID:107841 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107841 BioGRID:116406 ZHX1    BioGRID  PubMed Two-hybrid 
    BioGRID:107841 BioGRID:60648 esc    BioGRID  PubMed Biochemical Activity 

    General gene information

    Markers

    Homology

    • Homologs of the CSNK2A1 gene: The CSNK2A1 gene is conserved in , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Adherens junction, organism-specific biosystem (from KEGG)
      Adherens junction, organism-specific biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Adherens junction, conserved biosystem (from KEGG)
      Adherens junction, conserved biosystemCell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation....
    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • BCR signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      BCR signaling pathway, organism-specific biosystem
      BCR signaling pathway
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem (from Pathway Interaction Database)
      Lissencephaly gene (LIS1) in neuronal migration and development, organism-specific biosystem
      Lissencephaly gene (LIS1) in neuronal migration and development
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • PDGFR-alpha signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      PDGFR-alpha signaling pathway, organism-specific biosystem
      PDGFR-alpha signaling pathway
    • Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
      Presenilin action in Notch and Wnt signaling, organism-specific biosystem
      Presenilin action in Notch and Wnt signaling
    • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
      Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
    • Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Role of Calcineurin-dependent NFAT signaling in lymphocytes, organism-specific biosystem
      Role of Calcineurin-dependent NFAT signaling in lymphocytes
    • Signal transduction by L1, organism-specific biosystem (from REACTOME)
      Signal transduction by L1, organism-specific biosystemBesides adhesive roles in cell cell interaction, L1 functions as a signal transducing receptor providing neurons with cues from their environment for axonal growth and guidance. L1 associates with be...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Tight junction, organism-specific biosystem (from KEGG)
      Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Tight junction, conserved biosystem (from KEGG)
      Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    Hsp90 protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
     
    protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon guidance TAS
    Traceable Author Statement
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    chaperone-mediated protein folding TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic cell cycle spindle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    NuRD complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with PcG protein complex IDA
    Inferred from Direct Assay
    more info
     
    Sin3 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    casein kinase II subunit alpha
    Names
    casein kinase II subunit alpha
    CK II alpha
    protein kinase CK2
    CK2 catalytic subunit alpha
    casein kinase II alpha 1 subunit
    NP_001886.1
    NP_808227.1
    NP_808228.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011970.1 RefSeqGene

      Range
      5001..66145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001895.3NP_001886.1  casein kinase II subunit alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF011920, AU133318, BC053532, M55265
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      P68400
      Related
      ENSP00000339247, OTTHUMP00000029925, ENST00000349736, OTTHUMT00000077465
      Conserved Domains (2) summary
      pfam00069
      Location:39324
      Blast Score: 560
      Pkinase; Protein kinase domain
      cl09925
      Location:39324
      Blast Score: 517
      PKc_like; Protein Kinases, catalytic domain
    2. NM_177559.2NP_808227.1  casein kinase II subunit alpha isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AF011920, AU132198, BC053532, M55265
      Consensus CDS
      CCDS13003.1
      UniProtKB/Swiss-Prot
      P68400
      Related
      ENSP00000217244, OTTHUMP00000029926, ENST00000217244, OTTHUMT00000077466
      Conserved Domains (2) summary
      pfam00069
      Location:39324
      Blast Score: 560
      Pkinase; Protein kinase domain
      cl09925
      Location:39324
      Blast Score: 517
      PKc_like; Protein Kinases, catalytic domain
    3. NM_177560.2NP_808228.1  casein kinase II subunit alpha isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR as well as the first coding exon compared to variant 1, resulting in an isoform (b) which is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AF011920, AU132198, AY735339, BC053532, M55265
      Consensus CDS
      CCDS13004.1
      UniProtKB/Swiss-Prot
      P68400
      Related
      ENSP00000383076, ENST00000400217
      Conserved Domains (1) summary
      cl09925
      Location:1188
      Blast Score: 437
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000020.10 Reference GRCh37.p5 Primary Assembly

      Range
      463338..524482, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000152.1 Alternate HuRef

      Range
      414534..475783, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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