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Gdf11 growth differentiation factor 11 [ Mus musculus (house mouse) ]

Gene ID: 14561, updated on 8-May-2016
Official Symbol
Gdf11provided by MGI
Official Full Name
growth differentiation factor 11provided by MGI
Primary source
MGI:MGI:1338027
See related
Ensembl:ENSMUSG00000025352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmp11; BMP-11
Orthologs
Location:
10; 10 D3
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 10 NC_000076.6 (128884546..128891718, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (128321602..128328774, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C14 Neighboring gene ORM1-like 2 (S. cerevisiae) Neighboring gene SAP domain containing ribonucleoprotein Neighboring gene CD63 antigen Neighboring gene retinol dehydrogenase 5 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth IEA
Inferred from Electronic Annotation
more info
 
metanephros development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
palate development IGI
Inferred from Genetic Interaction
more info
PubMed 
pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
spinal cord anterior/posterior patterning IMP
Inferred from Mutant Phenotype
more info
PubMed 
ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
growth/differentiation factor 11
Names
GDF-11
bone morphogenetic protein 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010272.1NP_034402.1  growth/differentiation factor 11 precursor

    See identical proteins and their annotated locations for NP_034402.1

    Status: VALIDATED

    Source sequence(s)
    AC122380
    Consensus CDS
    CCDS24296.1
    UniProtKB/Swiss-Prot
    Q9Z1W4
    Related
    ENSMUSP00000026408, OTTMUSP00000043782, ENSMUST00000026408, OTTMUST00000081761
    Conserved Domains (2) summary
    smart00204
    Location:311405
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:58285
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p3 C57BL/6J

    Range
    128884546..128891718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000032.1 Alternate Mm_Celera

    Range
    131277119..131283965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)