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CSNK1G3 casein kinase 1 gamma 3 [ Homo sapiens (human) ]

Gene ID: 1456, updated on 8-May-2016
Official Symbol
CSNK1G3provided by HGNC
Official Full Name
casein kinase 1 gamma 3provided by HGNC
Primary source
HGNC:HGNC:2456
See related
Ensembl:ENSG00000151292 HPRD:05034; MIM:604253; Vega:OTTHUMG00000128923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSNK1G3L; CKI-gamma 3
Summary
This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Orthologs
Location:
5q23
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (123512099..123617045)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122847793..122952739)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene centrosomal protein 120 Neighboring gene keratin 8 pseudogene 33 Neighboring gene high mobility group box 3 pseudogene 17 Neighboring gene keratin 18 pseudogene 16 Neighboring gene long intergenic non-protein coding RNA 1170 Neighboring gene uncharacterized LOC101927397

NHGRI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein casein kinase 1, gamma 3 (CSNK1G3) PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
casein kinase I isoform gamma-3
Names
casein kinase 1, gamma 3
NP_001026982.1
NP_001038188.1
NP_001257501.1
NP_001257502.1
NP_001257503.1
NP_004375.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031812.3NP_001026982.1  casein kinase I isoform gamma-3 isoform 2

    See identical proteins and their annotated locations for NP_001026982.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AF049089, BC047567, BX116822, DA409424
    Consensus CDS
    CCDS34218.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000334735, ENST00000345990
    Conserved Domains (3) summary
    pfam00069
    Location:43299
    Pkinase; Protein kinase domain
    pfam12605
    Location:331385
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  2. NM_001044723.2NP_001038188.1  casein kinase I isoform gamma-3 isoform 4

    See identical proteins and their annotated locations for NP_001038188.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as CSNK1G3L) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC008541, AF049090, BC047567, BX116822
    Consensus CDS
    CCDS43355.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000353904, OTTHUMP00000159175, ENST00000360683, OTTHUMT00000250901
    Conserved Domains (3) summary
    pfam00069
    Location:43299
    Pkinase; Protein kinase domain
    pfam12605
    Location:331417
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  3. NM_001270572.1NP_001257501.1  casein kinase I isoform gamma-3 isoform 5

    See identical proteins and their annotated locations for NP_001257501.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC008541, AK289405, BC047567, BX116822
    Consensus CDS
    CCDS59491.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000423838, OTTHUMP00000223000, ENST00000510842, OTTHUMT00000371238
    Conserved Domains (2) summary
    pfam12605
    Location:332386
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  4. NM_001270573.1NP_001257502.1  casein kinase I isoform gamma-3 isoform 6

    See identical proteins and their annotated locations for NP_001257502.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008541, AK299739, BX116822, DA409424
    Consensus CDS
    CCDS59492.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421998, OTTHUMP00000223001, ENST00000512718, OTTHUMT00000371239
    Conserved Domains (2) summary
    pfam12605
    Location:256310
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1253
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001270574.1NP_001257503.1  casein kinase I isoform gamma-3 isoform 7

    See identical proteins and their annotated locations for NP_001257503.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple differences in the coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (7) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC008541, AK316019, BX116822, DA409424
    Consensus CDS
    CCDS59493.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000421385, OTTHUMP00000223002, ENST00000511130, OTTHUMT00000371240
    Conserved Domains (2) summary
    pfam12605
    Location:219273
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cl21453
    Location:1216
    PKc_like; Protein Kinases, catalytic domain
  6. NM_004384.4NP_004375.2  casein kinase I isoform gamma-3 isoform 1

    See identical proteins and their annotated locations for NP_004375.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC008541, AF049089, BC047567, BX116822
    Consensus CDS
    CCDS4135.1
    UniProtKB/Swiss-Prot
    Q9Y6M4
    Related
    ENSP00000354942, OTTHUMP00000159174, ENST00000361991, OTTHUMT00000250900
    Conserved Domains (3) summary
    pfam00069
    Location:43299
    Pkinase; Protein kinase domain
    pfam12605
    Location:331417
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    123512099..123617045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271895.1XP_005271952.1  

    See identical proteins and their annotated locations for XP_005271952.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (2) summary
    pfam12605
    Location:332386
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  2. XM_005271891.1XP_005271948.1  

    See identical proteins and their annotated locations for XP_005271948.1

    Conserved Domains (2) summary
    pfam12605
    Location:332418
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  3. XM_005271893.1XP_005271950.1  

    See identical proteins and their annotated locations for XP_005271950.1

    Conserved Domains (2) summary
    pfam12605
    Location:332418
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  4. XM_005271896.1XP_005271953.1  

    See identical proteins and their annotated locations for XP_005271953.1

    Conserved Domains (2) summary
    pfam12605
    Location:332386
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42329
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  5. XM_005271892.2XP_005271949.1  

    See identical proteins and their annotated locations for XP_005271949.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (3) summary
    pfam00069
    Location:43299
    Pkinase; Protein kinase domain
    pfam12605
    Location:331417
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
  6. XM_005271894.2XP_005271951.1  

    See identical proteins and their annotated locations for XP_005271951.1

    UniProtKB/Swiss-Prot
    Q9Y6M4
    Conserved Domains (3) summary
    pfam00069
    Location:43299
    Pkinase; Protein kinase domain
    pfam12605
    Location:331417
    CK1gamma_C; Casein kinase 1 gamma C terminal
    cd14126
    Location:42328
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    122280390..122385357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044722.1: Suppressed sequence

    Description
    NM_001044722.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.